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1.发明公开公开(公告)号：US20240191306A1
公开(公告)日：2024-06-13
申请号：US18430156
申请日：2024-02-01
Applicant: Case Western Reserve University
Inventor： Sanford D. Markowitz , Helen Moinova , Amitabh Chak , Joseph Willis , Thomas LaFramboise
IPC: C12Q1/6886 , C12Q1/6827 , C12Q1/6853 , G01N33/574
CPC classification number: C12Q1/6886 , C12Q1/6827 , C12Q1/6853 , G01N33/574 , C12Q2600/154 , C12Q2600/156
Abstract: The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.
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公开(公告)号：US20170369948A1
公开(公告)日：2017-12-28
申请号：US15540965
申请日：2015-12-31
Applicant: Case Western Reserve University
Inventor： Sanford D. Markowitz , Joseph E. Willis , Helen Moinova , Thomas LaFramboise , Omar de la Cruz Cabrera , Ryan Fecteau
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q1/6806 , C12Q1/6837 , C12Q1/686 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
Abstract: The disclosure provides methods for identifying genomic loci that are differentially methylated in colorectal neoplasias. Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have colorectal neoplasias.
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公开(公告)号：US20240417776A1
公开(公告)日：2024-12-19
申请号：US18026255
申请日：2021-09-23
Applicant: Case Western Reserve University
Inventor： Sanford D. Markowitz , Helen Moinova
IPC: C12Q1/6806 , A01N1/00 , C12N15/10
Abstract: The disclosure provides methods for storage solutions for preserving DNA methylation patterns over a period of time. The disclosure also provides for methods of using methylated DNA stored in such storage solutions.
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4.发明申请公开(公告)号：US20190136325A1
公开(公告)日：2019-05-09
申请号：US15540956
申请日：2015-12-30
Applicant: Case Western Reserve University
Inventor： Sanford D. Markowitz , Joseph E. Willis , Helen Moinova , Thomas LaFramboise , Omar de la Cruz Cabrera , Amitabh Chak
IPC: C12Q1/6886 , C12Q1/6806 , C12Q1/686 , C12Q1/6837
Abstract: The disclosure provides methods for identifying genomic loci that are differentially/methylated in neoplastic cancers, e.g., esophageal cancers. Identification of methylated genomic loci, and optionally in combination with the identification of somatic mutations in TP53, has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal neoplasias.
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5.发明申请ABERRANT METHYLATION OF C6ORF150 DNA SEQUENCES IN HUMAN COLORECTAL CANCER 审中-公开人类癌症患者C6ORF150 DNA序列的甲基化公开(公告)号：US20140113290A1
公开(公告)日：2014-04-24
申请号：US14109041
申请日：2013-12-17
Inventor： Sanford D. Markowitz , Helen Moinova , Lois Myeroff , Jean-Pierre Issa , Osamu Maeda
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , G01N33/57419 , G01N2500/10 , G01N2800/56
Abstract: This application describes methods and compositions for detecting and treating C6Orf150-associated neoplasia. Differential methylation of the C6Orf150 nucleotide sequences has been observed in C6Orf150-associated neoplasia such as colon neoplasia.
Abstract translation: 本申请描述了用于检测和治疗C6Orf150相关瘤形成的方法和组合物。 在C6Orf150相关的肿瘤形成例如结肠瘤形成中观察到C6Orf150核苷酸序列的差异甲基化。
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Patent Agency Ranking
6.发明授权公开(公告)号：US12227810B2
公开(公告)日：2025-02-18
申请号：US18430156
申请日：2024-02-01
Applicant: Case Western Reserve University
Inventor： Sanford D. Markowitz , Helen Moinova , Amitabh Chak , Joseph Willis , Thomas LaFramboise
IPC: C12Q1/68 , C12Q1/6827 , C12Q1/6853 , C12Q1/6886 , G01N33/574
Abstract: The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.
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7.发明公开公开(公告)号：US20240068045A1
公开(公告)日：2024-02-29
申请号：US18381926
申请日：2023-10-19
Applicant: Case Western Reserve University
Inventor： Sanford D. Markowitz , Joseph E. Willis , Helen Moinova , Thomas LaFramboise , Omar de la Cruz Cabrera , Amitabh Chak
IPC: C12Q1/6886 , C12Q1/6806 , C12Q1/6837 , C12Q1/686
CPC classification number: C12Q1/6886 , C12Q1/6806 , C12Q1/6837 , C12Q1/686 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
Abstract: The disclosure provides methods for identifying genomic loci that are differentially methylated in neoplastic cancers, e.g., esophageal cancers. Identification of methylated genomic loci, and optionally in combination with the identification of somatic mutations in TP53, has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal neoplasias.
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8.发明公开公开(公告)号：US20240068033A1
公开(公告)日：2024-02-29
申请号：US18261366
申请日：2022-01-14
Inventor： Sanford Markowitz , Amitabh Chak , Helen Moinova , Joseph Willis , Bert Vogelstein , Kenneth Kinzler , Nickolas Papadopoulos , Chetan Bettewgowda , Christopher Douville
IPC: C12Q1/6883
CPC classification number: C12Q1/6883 , C12Q2600/118 , C12Q2600/156
Abstract: A method of detecting Barrett's esophagus with low grade dysplasia, or Barrett's esophagus with high grade dysplasia, or adenocarcinoma of the esophagus, applying a Repetitive Element Aneuploidy Sequencing System (RealSeqS) methodology to a biological sample from the esophagus of the subject to detect Barrett's esophagus with low grade dysplasia, or Barrett's esophagus with high grade dysplasia, or adenocarcinoma of the esophagus.
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公开(公告)号：US20220243281A1
公开(公告)日：2022-08-04
申请号：US17613825
申请日：2020-05-28
Applicant: Case Western Reserve University
Inventor： Sanford D. Markowitz , Helen Moinova , David Wurtman
IPC: C12Q1/6886 , C12N15/10 , C12Q1/6806
Abstract: The disclosure provides methods for storage solutions for preserving DNA methylation patterns over a period of time. The disclosure also provides for methods of using methylated DNA stored in such storage solutions.
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10.发明授权公开(公告)号：US12258632B2
公开(公告)日：2025-03-25
申请号：US16315405
申请日：2017-07-05
Applicant: Case Western Reserve University
Inventor： Sanford D. Markowitz , Helen Moinova , Amitabh Chak , Joseph Willis , Thomas LaFramboise
IPC: C12Q1/68 , C12Q1/6827 , C12Q1/6853 , C12Q1/6886 , G01N33/574
Abstract: The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.
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