-
公开(公告)号：US20240285693A1
公开(公告)日：2024-08-29
申请号：US18424000
申请日：2024-01-26
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Dana Hayoun Neeman , Ofer Wiser , Ravid Tikotzki , Lilach Alon
CPC classification number: A61K35/30 , C12N5/0621 , C12N2501/15 , C12N2506/02 , C12N2531/00
Abstract: Presented herein are methods and compositions for expanding RPE cells with the use of a suspendable cell support matrix. Also provided are pharmaceutical compositions containing RPE cells, and methods of treating an eye disorder or disease using RPE cells.
-
公开(公告)号：US11987810B2
公开(公告)日：2024-05-21
申请号：US17546013
申请日：2021-12-08
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
CPC classification number: C12N5/0621 , A61K35/30 , C12N2500/02 , C12N2500/38 , C12N2501/115 , C12N2501/15 , C12N2501/16 , C12N2506/02 , C12N2533/52
Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
-
公开(公告)号：US20220408719A1
公开(公告)日：2022-12-29
申请号：US17893977
申请日：2022-08-23
Applicant: CELL CURE NEUROSCIENCES LTD.
Inventor： Nir Netzer , Ofer Wiser , Bat Shahaf , Orit Gamburg , Lior Rosenberg Belmaker , Dana Hayoun Neeman , Osnat Bohana Kashtan
Abstract: Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
-
Patent Agency Ranking
公开(公告)号：US11891622B2
公开(公告)日：2024-02-06
申请号：US15539473
申请日：2015-12-30
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
CPC classification number: C12N5/0621 , A61K35/30 , C12N2500/02 , C12N2500/38 , C12N2501/115 , C12N2501/15 , C12N2501/16 , C12N2506/02 , C12N2533/52
Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
-
公开(公告)号：US20230051803A1
公开(公告)日：2023-02-16
申请号：US17883263
申请日：2022-08-08
Applicant: CELL CURE NEUROSCIENCES LTD.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
Abstract: A method of qualifying whether a cell population is a suitable therapeutic for treating an eye condition is disclosed. The method comprises analyzing co-expression of premelanosome protein (PMEL17) and at least one polypeptide selected from the group consisting of cellular retinaldehyde binding protein (CRALBP), lecithin retinol acyltransferase (LRAT) and sex determining region Y-box 9 (SOX 9) in the population of cells.
-
公开(公告)号：US20220154141A1
公开(公告)日：2022-05-19
申请号：US17546013
申请日：2021-12-08
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
-
公开(公告)号：US20180016553A1
公开(公告)日：2018-01-18
申请号：US15539473
申请日：2015-12-30
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
CPC classification number: C12N5/0621 , A61K35/30 , C12N2500/02 , C12N2500/38 , C12N2501/115 , C12N2501/15 , C12N2501/16 , C12N2506/02 , C12N2533/52
Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
-
公开(公告)号：US20180011092A1
公开(公告)日：2018-01-11
申请号：US15539514
申请日：2015-12-30
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
IPC: G01N33/569 , A61K35/30 , C12N5/079
CPC classification number: G01N33/56966 , A61K35/30 , A61K35/545 , C12N5/0621 , C12N2500/02 , C12N2500/38 , C12N2501/115 , C12N2501/15 , C12N2501/16 , C12N2501/999 , C12N2502/1323 , C12N2506/02 , C12N2509/00 , C12N2533/54 , G01N33/57407 , G01N2333/47 , G01N2333/4703 , G01N2500/10
Abstract: A method of qualifying whether a cell population is a suitable therapeutic for treating an eye condition is disclosed. The method comprises analyzing co-expression of premelanosome protein (PMEL17) and at least one polypeptide selected from the group consisting of cellular retinaldehyde binding protein (CRALBP), lecithin retinol acyltransferase (LRAT) and sex determining region Y-box 9 (SOX 9) in the population of cells.
-
-
-
-
-
-
-
Search Results
18
records
(took 0.018 seconds)
