公开(公告)号：US20080195211A1

公开(公告)日：2008-08-14

申请号：US11927281

申请日：2007-10-29

Applicant: Chia-Ying Lin ,  Frank LaMarca ,  Stephen E. Feinberg ,  William L. Murphy ,  James R. Adox ,  Scott J. Hollister

Inventor： Chia-Ying Lin ,  Frank LaMarca ,  Stephen E. Feinberg ,  William L. Murphy ,  James R. Adox ,  Scott J. Hollister

IPC: A61F2/44 ,  G06G7/60

CPC classification number: A61F2/442 ,  A61F2/28 ,  A61F2/2846 ,  A61F2/30767 ,  A61F2/30942 ,  A61F2/3662 ,  A61F2/389 ,  A61F2002/2817 ,  A61F2002/30004 ,  A61F2002/30014 ,  A61F2002/30034 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30224 ,  A61F2002/30271 ,  A61F2002/30578 ,  A61F2002/30599 ,  A61F2002/30604 ,  A61F2002/30616 ,  A61F2002/30761 ,  A61F2002/30777 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30838 ,  A61F2002/30841 ,  A61F2002/30884 ,  A61F2002/30892 ,  A61F2002/3092 ,  A61F2002/30948 ,  A61F2002/30962 ,  A61F2002/30968 ,  A61F2002/3097 ,  A61F2002/30991 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0014 ,  A61F2250/0018 ,  A61F2250/0031 ,  A61F2250/0063 ,  A61F2250/0098 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00293 ,  A61F2310/00796 ,  A61F2310/00976 ,  B33Y50/00 ,  B33Y80/00

Abstract: Methods for the engineering and preparation of intervertebral disc repair scaffolds and articulating joint repair scaffolds are disclosed. The methodology utilizes either magnetic resonance images or combined magnetic resonance and computed tomography images as a template for creating either the intervertebral scaffold or the joint repair scaffold (e.g., osteochondral scaffold) with fixation to the underlying bone. The disc scaffold design may include an outer annulus that may contain desired structures and a central nucleus pulposus region that could either contain a designed microstructure or a contained hydrogel. The osteochondral scaffold may include a bone compartment interface with a cartilage compartment. The bone compartment may interface with a cutout portion of the bone through fixation components. Different microstructure designs may be created for the bone and cartilage compartment to represent desired mechanical and mass transport properties. The scaffolds are designed with a microstructure that controls elastic and permeability property distribution within the scaffold.

Abstract translation: 公开了椎间盘修复支架和铰接关节修复支架的工程和制备方法。 该方法利用磁共振图像或组合磁共振和计算机断层摄影图像作为模板，用于创建椎间骨支架或关节修复支架（例如骨软骨骨架），固定于下面的骨。 椎间盘支架设计可以包括可以包含所需结构的外环和可以包含设计的微结构或所含的水凝胶的中央髓核区。 骨软骨支架可以包括与软骨隔室的骨隔室界面。 骨隔室可以通过固定部件与骨的切口部分相接触。 可以为骨和软骨隔室创建不同的微结构设计来表示所需的机械和质量传输性质。 支架被设计成具有控制支架内的弹性和渗透性分布的微结构。

公开(公告)号：US20120330423A1

公开(公告)日：2012-12-27

申请号：US13595333

申请日：2012-08-27

Applicant: Chia-Ying Lin ,  Frank LaMarca ,  Stephen E. Feinberg ,  William L. Murphy ,  James R. Adox ,  Scott J. Hollister

Inventor： Chia-Ying Lin ,  Frank LaMarca ,  Stephen E. Feinberg ,  William L. Murphy ,  James R. Adox ,  Scott J. Hollister

IPC: A61F2/44 ,  A61P19/08 ,  A61K35/28 ,  A61K9/00 ,  A61K35/32

CPC classification number: A61F2/442 ,  A61F2/28 ,  A61F2/2846 ,  A61F2/30767 ,  A61F2/30942 ,  A61F2/3662 ,  A61F2/389 ,  A61F2002/2817 ,  A61F2002/30004 ,  A61F2002/30014 ,  A61F2002/30034 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30224 ,  A61F2002/30271 ,  A61F2002/30578 ,  A61F2002/30599 ,  A61F2002/30604 ,  A61F2002/30616 ,  A61F2002/30761 ,  A61F2002/30777 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30838 ,  A61F2002/30841 ,  A61F2002/30884 ,  A61F2002/30892 ,  A61F2002/3092 ,  A61F2002/30948 ,  A61F2002/30962 ,  A61F2002/30968 ,  A61F2002/3097 ,  A61F2002/30991 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0014 ,  A61F2250/0018 ,  A61F2250/0031 ,  A61F2250/0063 ,  A61F2250/0098 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00293 ,  A61F2310/00796 ,  A61F2310/00976 ,  B33Y50/00 ,  B33Y80/00

Abstract: Methods for the engineering and preparation of intervertebral disc repair scaffolds and articulating joint repair scaffolds are disclosed. The methodology utilizes either magnetic resonance images or combined magnetic resonance and computed tomography images as a template for creating either the intervertebral scaffold or the joint repair scaffold (e.g., osteochondral scaffold) with fixation to the underlying bone. The disc scaffold design may include an outer annulus that may contain desired structures and a central nucleus pulposus region that could either contain a designed microstructure or a contained hydrogel. The osteochondral scaffold may include a bone compartment interface with a cartilage compartment. The bone compartment may interface with a cutout portion of the bone through fixation components. Different microstructure designs may be created for the bone and cartilage compartment to represent desired mechanical and mass transport properties. The microstructure controls elastic and permeability property distribution within the scaffold.

Abstract translation: 公开了椎间盘修复支架和铰接关节修复支架的工程和制备方法。 该方法利用磁共振图像或组合磁共振和计算机断层摄影图像作为模板，用于创建椎间骨支架或关节修复支架（例如骨软骨骨架），固定于下面的骨。 椎间盘支架设计可以包括可以包含所需结构的外环和可以包含设计的微结构或所含的水凝胶的中心髓核区。 骨软骨支架可以包括与软骨隔室的骨隔室界面。 骨隔室可以通过固定部件与骨的切口部分相接触。 可以为骨和软骨隔室创建不同的微结构设计来表示所需的机械和质量传输性质。 微结构控制支架内的弹性和渗透性分布。

公开(公告)号：US20070270844A1

公开(公告)日：2007-11-22

申请号：US11800086

申请日：2007-05-03

Applicant: Chia-Ying Lin ,  Scott Hollister ,  Frank La Marca

Inventor： Chia-Ying Lin ,  Scott Hollister ,  Frank La Marca

IPC: A61F2/44

CPC classification number: A61F2/4455 ,  A61F2/28 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30599 ,  A61F2002/30622 ,  A61F2002/448 ,  A61F2002/449 ,  A61F2210/0004 ,  A61F2250/0063 ,  A61F2310/00365

Abstract: A biodegradable implant for use in intertransverse process spinal fusion having an absorbable matrix having a bone generating material disposed therein. A molded biodegradable case being made of bioabsorbable polymer can at least partially surround the absorbable matrix to carry a substantial portion of compression force relative to said absorbable matrix.

Abstract translation: 一种可用于跨过程脊柱融合的可生物降解植入物，其具有设置在其中的骨发生材料的可吸收基质。 由生物可吸收聚合物制成的模制的可生物降解的壳体可以至少部分地围绕可吸收的基质以承载相对于所述可吸收的基质的大部分压缩力。