公开(公告)号：US20240335300A1

公开(公告)日：2024-10-10

申请号：US18628596

申请日：2024-04-05

Applicant: Samy Abdou

Inventor： Samy Abdou

IPC: A61F2/46 ,  A61F2/28 ,  A61F2/30 ,  A61F2/44

CPC classification number: A61F2/4611 ,  A61F2/442 ,  A61F2/4455 ,  A61F2/4601 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30153 ,  A61F2002/30433 ,  A61F2002/30578 ,  A61F2002/30593 ,  A61F2/30744 ,  A61F2002/30774 ,  A61F2002/3093 ,  A61F2002/448 ,  A61F2/4603 ,  A61F2002/4627 ,  A61F2002/4629 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00131 ,  A61F2310/00179

Abstract: Placement apparatus and methods of use for impanation of spacers within an inter-vertebral disc space. In one embodiment, the load-bearing superstructure of the implant is subdivided and the bone forming material is positioned within an internal space of the placement instrument but external to the load bearing elements themselves. At least a portion of the bone graft material is freely contained within the disc space. A method of using the device is also described. In one embodiment, the placement device is used to place the implantable spacers at opposing ends of the disc space using a directly lateral surgical approach.

公开(公告)号：US12059186B2

公开(公告)日：2024-08-13

申请号：US16506353

申请日：2019-07-09

Applicant: Stryker European Operations Holdings, LLC

Inventor： Bernard Prandi ,  Marc Augoyard ,  Thomas Ledermann ,  Tristan Meusnier ,  Jacques Peyrot ,  Judith Fellmann

IPC: A61B17/68 ,  A61B17/16 ,  A61B17/72 ,  A61B17/86 ,  A61B17/88 ,  A61F2/42 ,  A61B17/00 ,  A61F2/30

CPC classification number: A61B17/8605 ,  A61B17/1655 ,  A61B17/68 ,  A61B17/7233 ,  A61B17/88 ,  A61F2/4225 ,  A61F2/4241 ,  A61B2017/00862 ,  A61B2017/681 ,  A61B17/7208 ,  A61B17/7225 ,  A61B17/7266 ,  A61B17/7283 ,  A61B2017/8655 ,  A61F2002/30062 ,  A61F2002/30563 ,  A61F2002/30622 ,  A61F2002/3085 ,  A61F2002/30878 ,  A61F2210/0004

Abstract: The invention relates to a resorptive intramedullary implant between two bones or two bone fragments. The implant includes a single-piece body (1) having a generally elongate shape and having, at each end, areas for anchoring to the bone portions in question, characterized in that one of said areas (A1) has a cylindrical cross-section while the other area (A2) has a flat cross-section.

公开(公告)号：US20240245526A1

公开(公告)日：2024-07-25

申请号：US18623020

申请日：2024-03-31

Applicant: Institute for Musculoskeletal Science and Education, Ltd.

Inventor： James A. Sack

IPC: A61F2/44 ,  A61B17/68 ,  A61F2/28 ,  A61F2/30 ,  A61F2/46 ,  A61L27/36

CPC classification number: A61F2/4455 ,  A61F2/2846 ,  A61F2/30767 ,  A61B17/68 ,  A61F2002/30062 ,  A61F2002/30112 ,  A61F2002/30125 ,  A61F2002/30156 ,  A61F2002/30224 ,  A61F2002/3023 ,  A61F2002/30289 ,  A61F2002/30593 ,  A61F2002/3093 ,  A61F2002/30985 ,  A61F2002/4495 ,  A61F2002/4629 ,  A61F2250/0026 ,  A61L27/3608

Abstract: An intervertebral implant comprising a body formed as an open truss structure, the body having a generally annular shape with a superior surface, an inferior surface, and a perimeter surface extending around an outer periphery of the body. The body may have a central portion and a peripheral portion, the peripheral portion extending inward from the perimeter surface toward the central portion, the peripheral portion including a first set of trusses, and the central portion including a second set of trusses. The implant may further include a strut at least partially defining a boundary between the central portion and the peripheral portion, wherein the strut has an oblong cross-sectional shape oriented to facilitate flow of bone graft material in a substantially radial direction away from the central axis.

公开(公告)号：US20240245515A1

公开(公告)日：2024-07-25

申请号：US18621297

申请日：2024-03-29

Applicant: Collagen Matrix, Inc.

Inventor： Shu-Tung Li ,  Hui-Chen Chen ,  Debbie Yuen

IPC: A61F2/28 ,  A61F2/30 ,  A61L27/12 ,  A61L27/24 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58

CPC classification number: A61F2/28 ,  A61F2/30756 ,  A61L27/12 ,  A61L27/24 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/54 ,  A61L27/58 ,  A61F2002/2839 ,  A61F2002/30016 ,  A61F2002/30062 ,  A61F2002/30293 ,  A61F2002/3092 ,  A61F2310/00371 ,  A61L2430/02 ,  A61L2430/06

Abstract: An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing silicate based glass. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant.

公开(公告)号：US12005160B2

公开(公告)日：2024-06-11

申请号：US16996245

申请日：2020-08-18

Applicant: WARSAW ORTHOPEDIC INC.

Inventor： Anthony J. Melkent ,  Brian R. Thoren ,  Timothy J. N. Smith ,  Ian D. Grant ,  Ian R. Dunkley

IPC: A61L31/12 ,  A61F2/44 ,  A61L27/42 ,  A61L27/56 ,  A61L27/58 ,  B05D1/18 ,  B05D3/02 ,  B29C45/00 ,  B29C45/14 ,  C04B38/00 ,  C04B41/45 ,  C04B41/81 ,  C08L71/12 ,  A61F2/30 ,  A61L27/46 ,  B29K71/00 ,  B29L31/00

CPC classification number: A61L31/121 ,  A61F2/4455 ,  A61L27/425 ,  A61L27/56 ,  A61L27/58 ,  B05D1/18 ,  B05D3/0272 ,  B29C45/0055 ,  B29C45/14795 ,  C04B38/0051 ,  C04B41/4586 ,  C04B41/81 ,  C08L71/12 ,  A61F2002/30028 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/30187 ,  A61F2002/30593 ,  A61F2/30724 ,  A61F2002/30957 ,  A61F2002/30973 ,  A61L27/46 ,  A61L2400/08 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/04 ,  B29C2045/0058 ,  B29K2071/00 ,  B29L2031/7532 ,  C04B2235/606 ,  A61L27/425 ,  C08L71/12

Abstract: Implantable medical devices are provided. In one embodiment, a device includes a body having an external surface defining an outer profile of the device. The body includes a porous matrix including a series of interconnected macropores defined by a plurality of interconnected struts each including a hollow interior. A filler material substantially fills at least a portion of the series of interconnected macropores. The external surface of the body includes a plurality of openings communicating with the hollow interior of at least a portion of the plurality of interconnected struts. In a further aspect of this embodiment, the external surface includes exposed areas of the filler material and porous matrix in addition to the exposed openings. In another aspect, the porous matrix is formed from a bioresorbable ceramic and the filler material is a biologically stable polymeric material. Still, other aspects related to this and other embodiments are also disclosed.

公开(公告)号：US11998251B2

公开(公告)日：2024-06-04

申请号：US17670279

申请日：2022-02-11

Applicant: P Tech, LLC

Inventor： Peter M. Bonutti ,  Matthew J. Cremens ,  Justin E. Beyers

IPC: A61B17/80 ,  A61B17/04 ,  A61B17/68 ,  A61B17/70 ,  A61B17/72 ,  A61B17/82 ,  A61B17/86 ,  A61B17/88 ,  A61F2/40 ,  A61B17/00 ,  A61B17/11 ,  A61B17/17 ,  A61B17/32 ,  A61F2/28 ,  A61F2/30 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/38 ,  A61F2/42 ,  A61F2/44 ,  A61F2/46 ,  A61F2/82 ,  G06F21/10

CPC classification number: A61B17/7233 ,  A61B17/0401 ,  A61B17/686 ,  A61B17/7032 ,  A61B17/7058 ,  A61B17/7059 ,  A61B17/7062 ,  A61B17/72 ,  A61B17/725 ,  A61B17/80 ,  A61B17/8033 ,  A61B17/82 ,  A61B17/866 ,  A61B17/88 ,  A61B17/8863 ,  A61F2/4081 ,  A61B2017/00004 ,  A61B2017/00504 ,  A61B2017/0409 ,  A61B2017/044 ,  A61B17/11 ,  A61B17/1128 ,  A61B17/1146 ,  A61B17/1721 ,  A61B17/1742 ,  A61B17/320068 ,  A61B17/8038 ,  A61B2017/8655 ,  A61B17/8685 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30065 ,  A61F2002/30133 ,  A61F2002/30451 ,  A61F2002/30604 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2/30756 ,  A61F2002/30785 ,  A61F2002/30787 ,  A61F2002/30878 ,  A61F2002/30892 ,  A61F2002/30894 ,  A61F2002/30971 ,  A61F2002/30973 ,  A61F2/32 ,  A61F2002/3401 ,  A61F2002/3403 ,  A61F2/3603 ,  A61F2/38 ,  A61F2/3804 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/40 ,  A61F2/4202 ,  A61F2002/444 ,  A61F2/4455 ,  A61F2/468 ,  A61F2002/828 ,  A61F2210/0004 ,  A61F2210/0071 ,  A61F2220/0058 ,  A61F2230/0015 ,  A61F2250/0068 ,  A61F2310/00011 ,  A61F2310/00365 ,  A61F2310/00383 ,  G06F21/1077 ,  G06F2221/2137

Abstract: The present invention provides a method for stabilizing a fractured bone. The method includes positioning an elongate rod in the medullary canal of the fractured bone and forming a passageway through the cortex of the bone. The passageway extends from the exterior surface of the bone to the medullary canal of the bone. The method also includes creating a bonding region on the elongate rod. The bonding region is generally aligned with the passageway of the cortex. Furthermore, the method includes positioning a fastener in the passageway of the cortex and on the bonding region of the elongate rod and thermally bonding the fastener to the bonding region of the elongate rod while the fastener is positioned in the passageway of the cortex.

公开(公告)号：US11931484B2

公开(公告)日：2024-03-19

申请号：US17150194

申请日：2021-01-15

Applicant: Razmodics LLC

Inventor： Kamal Ramzipoor ,  Richard J. Saunders

IPC: B05D1/18 ,  A61F2/07 ,  A61F2/82 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  A61L31/16 ,  B29C41/00 ,  B29C41/14 ,  A61F2/24 ,  A61F2/30 ,  B29C49/00 ,  B29K105/00 ,  B29L31/00

CPC classification number: A61L31/148 ,  A61F2/07 ,  A61F2/82 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  A61L31/16 ,  B29C41/003 ,  B29C41/14 ,  A61F2/24 ,  A61F2002/30062 ,  A61F2002/30535 ,  A61F2210/0004 ,  A61F2210/0019 ,  A61F2240/004 ,  B29C49/00 ,  B29K2105/0035 ,  B29K2995/0056 ,  B29L2031/7532

Abstract: A bioabsorbable composite stent structure, comprising bioabsorbable polymeric ring structures which retain a molecular weight and mechanical strength of a starting substrate and one or more interconnecting struts which extend between and couple adjacent ring structures. The ring structures can have a formed first diameter and being radially compressible to a smaller second diameter and re-expandable to the first diameter. The ring structures can comprise a base polymeric layer. The interconnecting struts can be formed from a polymer blend or co-polymer of poly-L-lactide (PLLA) and an elastomeric polymer. The interconnecting struts each can have a width that is less than a circumference of one of the ring structures. The adjacent ring structures can be axially and rotationally movable relative to one another via the interconnecting struts. The interconnecting struts can also be bioabsorbable.

公开(公告)号：US20240075184A1

公开(公告)日：2024-03-07

申请号：US18272765

申请日：2022-01-10

Applicant: University of Georgia Research Foundation, Inc.

Inventor： Ramaraja P. Ramasamy ,  Hamid Asadi

IPC: A61L27/34 ,  A61F2/28 ,  A61L27/04 ,  A61L27/50 ,  A61L31/02 ,  A61L31/10 ,  A61L31/14

CPC classification number: A61L27/34 ,  A61F2/28 ,  A61L27/047 ,  A61L27/50 ,  A61L31/022 ,  A61L31/10 ,  A61L31/14 ,  A61F2002/30062

Abstract: Provided are biodegradable orthopedic implants, corrosion-resistant coating for orthopedic implants, and methods of making. The biodegradable orthopedic implant can include a Mg alloy having a coating including a first layer, a second layer, and a third layer. The first layer can be an oxide layer coated on an external surface of a magnesium alloy implant. The second layer can include lawsone embedded in PCL, and the third layer can include PCL. To manufacture the coated orthopedic implant, the implant can be immersed in an alkaline solution to form an oxide-coated implant and implant can then be coated with a PCL lawsone solution. An additional polymer protective layer can be added.

公开(公告)号：US20240065841A1

公开(公告)日：2024-02-29

申请号：US18459029

申请日：2023-08-30

Applicant: Apex Orthopedics, LLC

Inventor： Gregory C. Berlet ,  Stephen A. Brigido ,  Murray J. Penner

IPC: A61F2/28 ,  A61F2/46

CPC classification number: A61F2/28 ,  A61F2/4644 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30062

Abstract: Devices, systems and methods for surgical treatment of mid-foot disorders such as osteoarthritis, spacing disorders, or alignment disorders, including mid-foot arthroplasty devices and systems for the 2nd and 3rd tarsometatarsal (TMT) joint, implants for post-osteotomy spacing and realignment, arthroplasty articular implants, dowel grafts for TMT arthrodesis or fusion, dowel grafts for navicular cuneiform (NC) arthrodesis, dowel grafts for intercuneiform arthrodesis, and/or locking dowels for joint fusion.

公开(公告)号：US11844666B2

公开(公告)日：2023-12-19

申请号：US18189084

申请日：2023-03-23

Applicant: Pacific Biosciences of California, Inc.

Inventor： Benjamin Flusberg ,  Jonas Korlach ,  Andrey Kislyuk ,  Stephen Turner ,  Jon Sorenson ,  Kevin Travers ,  Cheryl Heiner ,  Austin B. Tomaney ,  Patrick Marks ,  Dale Webster ,  Jeremiah Hanes

IPC: G16B30/00 ,  A61F2/30 ,  C12Q1/6858 ,  C12Q1/6869 ,  A61F2/32 ,  A61F2/40 ,  A61F2/46

CPC classification number: A61F2/30721 ,  C12Q1/6858 ,  C12Q1/6869 ,  G16B30/00 ,  A61F2/30767 ,  A61F2/30965 ,  A61F2/32 ,  A61F2/40 ,  A61F2002/30004 ,  A61F2002/30062 ,  A61F2002/30235 ,  A61F2002/30242 ,  A61F2002/30245 ,  A61F2002/30324 ,  A61F2002/30593 ,  A61F2002/30757 ,  A61F2002/30971 ,  A61F2002/4635 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2230/0071 ,  A61F2250/0014 ,  A61F2250/0036

Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.