公开(公告)号：US20070124972A1

公开(公告)日：2007-06-07

申请号：US11392559

申请日：2006-03-30

申请人： Peter Ratcliffe

发明人： Peter Ratcliffe

IPC分类号： G09F21/04

CPC分类号： G09F21/04 ,  B60R13/005 ,  G09F7/00

摘要： A method of advertising involves providing one or more advertisements that attach to a vehicle with an attachment mechanism, by way of a base. Each advertisement can be easily detached from the base for the purposes of attaching another advertisement without removing the base from the vehicle. An attractive cap using an identical attachment mechanism can be provided to cover the base. The base, the advertisement, and the cap can be provided as a set. Advertisement designs can be quickly and conveniently swapped at the vehicle user's discretion because they all utilize a common base design. Advertisers may provide the user with an advertisement for the advertiser's product, and with a plate compatible with the base already on the user's vehicle. The present invention provides a novel way for individuals to advertise their likings and a novel way for organizations to reach consumer attention by creating roaming advertisements for new and established brands and markets.

摘要翻译： 广告的方法涉及通过基座提供附接到具有附接机构的车辆的一个或多个广告。 为了附加另一广告的目的，每个广告可以容易地从基座分离，而不从车辆移除基座。 可以提供使用相同的附接机构的有吸引力的盖子来覆盖基座。 基地，广告和帽可以作为一套提供。 广告设计可以快速方便地交换车辆用户的自由裁量权，因为它们都使用共同的基本设计。 广告商可以向用户提供广告商产品的广告，以及与已经在用户车辆上的基座兼容的板。 本发明提供了一种新颖的方式让个人通过为新的和已建立的品牌和市场创造漫游广告来宣传他们的喜好，并为组织提供新颖的方式来吸引消费者的注意。

公开(公告)号：US20060188981A1

公开(公告)日：2006-08-24

申请号：US11356568

申请日：2006-02-17

申请人： Adrian Harris ,  Peter Ratcliffe

发明人： Adrian Harris ,  Peter Ratcliffe

IPC分类号： C12N15/63

CPC分类号： G01N33/57492 ,  G01N2333/988 ,  G01N2800/52

摘要： Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked by organic or inorganic molecules, preferably organic molecules, more preferably proteins/polypeptides that specifically bind to that site. Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Vectors are provided that encode the variable domains of MN-specific antibodies and a flexible linker polypeptide separating those domains. Further vectors are disclosed that encode a cytotoxic protein/polypeptide operatively linked to the MN gene promoter or a MN gene promoter fragment comprising the HIF-1 consensus binding sequence, and which vectors preferably further encode a cytokine. The MN gene promoter is characterized, and the binding site for a repressor of MN transcription is disclosed. Further, the hypoxia inducibility of the MN gene and the uses of such induciblity inducibility are disclosed.

摘要翻译： 本文所确定的是MN蛋白结合位点的位置，以及用固定的MN蛋白竞争与脊椎动物细胞附着的MN蛋白质/多肽。 这样的MN蛋白/多肽防止细胞粘附和细胞间接触的形成。 MN蛋白结合位点是可被有机或无机分子，优选有机分子，更优选特异性结合该位点的蛋白质/多肽阻断的治疗靶标。 公开了抑制异常表达MN蛋白的肿瘤前/肿瘤脊椎动物细胞生长的治疗方法。 提供编码MN-特异性抗体的可变结构域的载体和分离这些结构域的柔性接头多肽。 公开了编码与MN基因启动子或包含HIF-1共有结合序列的MN基因启动子片段有效连接的细胞毒性蛋白质/多肽的其它载体，并且哪些载体优选进一步编码细胞因子。 表征MN基因启动子，并公开MN转录抑制子的结合位点。 此外，公开了MN基因的缺氧诱导能力和这种可诱导性诱导性的用途。