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    MN and hypoxia
    1.
    发明申请
    MN and hypoxia 审中-公开
    MN和缺氧

    公开(公告)号：US20060084123A1

    公开(公告)日：2006-04-20

    申请号：US11166997

    申请日：2005-06-24

    申请人： Adrian Harris ,  Peter Ratcliffe ,  Dirk Vordermark

    发明人： Adrian Harris ,  Peter Ratcliffe ,  Dirk Vordermark

    IPC分类号： G01N33/574

    CPC分类号： C12Q1/527 ,  G01N33/573 ,  G01N33/574

    摘要： The MN/CA IX protein is identified herein as a hypoxia marker. The MN/CA9 gene promoter is characterized, and the location of the HIF-1 binding site within the MN/CA9 promoter is identified. Further, the hypoxia inducibility of the MN/CA9 gene and the uses of such inducibility are disclosed. In one aspect, the invention provides diagnostic/prognostic tools for determining the presence of hypoxia in a tissue in a vertebrate, preferably a human, and for measuring the relative degree of hypoxia in said vertebrate. In another aspect, the invention provides methods using tumor biopsies to predict the radioresistance of a preneoplastic/neoplastic tissue in a vertebrate subject, preferably a human patient, for diseases in which MN/CA IX levels can be used to indicate radiobiologically relevant tumor hypoxia. Such predictive methods can be used as an aid in patient therapy selection.

    摘要翻译： 本文将MN / CA IX蛋白质鉴定为缺氧标记。 表征MN / CA9基因启动子，鉴定MN / CA9启动子内HIF-1结合位点的位置。 此外，公开了MN / CA9基因的缺氧诱导能力和这种诱导性的用途。 一方面，本发明提供用于确定脊椎动物，优选人类的组织中缺氧的存在并用于测量所述脊椎动物中的相对缺氧程度的诊断/预后工具。 在另一方面，本发明提供了使用肿瘤活组织检查来预测脊椎动物受试者，优选人类患者中对于其中可以使用MN / CA IX水平来表示放射生物学相关的肿瘤缺氧的疾病的肿瘤前/肿瘤组织的放射抗性的方法。 这种预测方法可用作患者治疗选择的辅助。

    MN gene and protein
    2.
    发明申请
    MN gene and protein 有权
    MN基因和蛋白质

    公开(公告)号：US20060188981A1

    公开(公告)日：2006-08-24

    申请号：US11356568

    申请日：2006-02-17

    申请人： Adrian Harris ,  Peter Ratcliffe

    发明人： Adrian Harris ,  Peter Ratcliffe

    IPC分类号： C12N15/63

    CPC分类号： G01N33/57492 ,  G01N2333/988 ,  G01N2800/52

    摘要： Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked by organic or inorganic molecules, preferably organic molecules, more preferably proteins/polypeptides that specifically bind to that site. Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Vectors are provided that encode the variable domains of MN-specific antibodies and a flexible linker polypeptide separating those domains. Further vectors are disclosed that encode a cytotoxic protein/polypeptide operatively linked to the MN gene promoter or a MN gene promoter fragment comprising the HIF-1 consensus binding sequence, and which vectors preferably further encode a cytokine. The MN gene promoter is characterized, and the binding site for a repressor of MN transcription is disclosed. Further, the hypoxia inducibility of the MN gene and the uses of such induciblity inducibility are disclosed.

    摘要翻译： 本文所确定的是MN蛋白结合位点的位置，以及用固定的MN蛋白竞争与脊椎动物细胞附着的MN蛋白质/多肽。 这样的MN蛋白/多肽防止细胞粘附和细胞间接触的形成。 MN蛋白结合位点是可被有机或无机分子，优选有机分子，更优选特异性结合该位点的蛋白质/多肽阻断的治疗靶标。 公开了抑制异常表达MN蛋白的肿瘤前/肿瘤脊椎动物细胞生长的治疗方法。 提供编码MN-特异性抗体的可变结构域的载体和分离这些结构域的柔性接头多肽。 公开了编码与MN基因启动子或包含HIF-1共有结合序列的MN基因启动子片段有效连接的细胞毒性蛋白质/多肽的其它载体，并且哪些载体优选进一步编码细胞因子。 表征MN基因启动子，并公开MN转录抑制子的结合位点。 此外，公开了MN基因的缺氧诱导能力和这种可诱导性诱导性的用途。

    Method and apparatus for displaying personalized information on a vehicle
    4.
    发明申请
    Method and apparatus for displaying personalized information on a vehicle 审中-公开
    用于在车辆上显示个性化信息的方法和装置

    公开(公告)号：US20080028650A1

    公开(公告)日：2008-02-07

    申请号：US11798835

    申请日：2007-05-17

    申请人： Peter Ratcliffe

    发明人： Peter Ratcliffe

    IPC分类号： G09F21/04

    CPC分类号： B60R13/005 ,  G09F7/00 ,  G09F21/04

    摘要： A way for a consumer to display personalized information is provided as a display device for displaying the personalized information or other objects, and an attachment mechanism that attaches the display device to a vehicle by way of a base and that is also detachable from the base. The personalized information may be placed on or inside the display device for the consumer, or the consumer may place the personalized information on or inside the display device himself. The personalized information may represent military affiliation, authorization, or may be any other personalized image or text. The base may be affixed to the vehicle by way of a magnet or other mechanism. The display device may include a recess for holding a can or cup. The display device may be pivoted relative to the base so that the display device may be displayed perpendicular or parallel to a plane defined by the vehicle's wheels.

    摘要翻译： 提供消费者显示个性化信息的方式作为显示个性化信息或其他对象的显示装置，以及通过基座将显示装置附接到车辆并且也可从基座拆卸的附接机构。 个性化信息可以放置在消费者的显示装​​置的内部或内部，或者消费者可以将个人化信息本身放置在显示装置内部或内部。 个性化信息可以表示军事联盟，授权，或可以是任何其他个性化图像或文本。 基座可以通过磁铁或其他机构固定在车辆上。 显示装置可以包括用于保持罐或杯的凹部。 显示装置可以相对于基座枢转，使得显示装置可以垂直或平行于由车辆的车轮限定的平面显示。

    Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers
    5.
    发明申请
    Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers 审中-公开
    2-氧戊二酸双加氧酶抑制剂作为γ珠蛋白诱导剂

    公开(公告)号：US20070042937A1

    公开(公告)日：2007-02-22

    申请号：US10566625

    申请日：2004-07-30

    申请人： Stephen Klaus ,  Peter Ratcliffe

    发明人： Stephen Klaus ,  Peter Ratcliffe

    IPC分类号： A61K38/40 ,  A61K48/00 ,  A61K31/7072 ,  A61K31/19

    CPC分类号： A61K31/7072 ,  A61K31/17 ,  A61K31/19 ,  A61K31/47 ,  Y02A50/411

    摘要： The present invention provides methods for increasing endogenous globin expression in a subject, specifically γ-globin expression. The invention also provides compounds and medicaments for use in the methods. The methods are particularly useful for increasing fetal hemoglobin production in a subject, and can be used to treat various disorders, e.g., β thalassemia and sickle cell disease.

    摘要翻译： 本发明提供增加受试者内源性珠蛋白表达，特别是γ-珠蛋白表达的方法。 本发明还提供了用于该方法的化合物和药物。 所述方法对于增加受试者的胎儿血红蛋白产生特别有用，并且可用于治疗各种疾病，例如β地中海贫血和镰状细胞病。

    Method and apparatus for advertising on a vehicle
    10.
    发明申请
    Method and apparatus for advertising on a vehicle 审中-公开
    在车辆上广告的方法和装置

    公开(公告)号：US20070124972A1

    公开(公告)日：2007-06-07

    申请号：US11392559

    申请日：2006-03-30

    申请人： Peter Ratcliffe

    发明人： Peter Ratcliffe

    IPC分类号： G09F21/04

    CPC分类号： G09F21/04 ,  B60R13/005 ,  G09F7/00

    摘要： A method of advertising involves providing one or more advertisements that attach to a vehicle with an attachment mechanism, by way of a base. Each advertisement can be easily detached from the base for the purposes of attaching another advertisement without removing the base from the vehicle. An attractive cap using an identical attachment mechanism can be provided to cover the base. The base, the advertisement, and the cap can be provided as a set. Advertisement designs can be quickly and conveniently swapped at the vehicle user's discretion because they all utilize a common base design. Advertisers may provide the user with an advertisement for the advertiser's product, and with a plate compatible with the base already on the user's vehicle. The present invention provides a novel way for individuals to advertise their likings and a novel way for organizations to reach consumer attention by creating roaming advertisements for new and established brands and markets.

    摘要翻译： 广告的方法涉及通过基座提供附接到具有附接机构的车辆的一个或多个广告。 为了附加另一广告的目的，每个广告可以容易地从基座分离，而不从车辆移除基座。 可以提供使用相同的附接机构的有吸引力的盖子来覆盖基座。 基地，广告和帽可以作为一套提供。 广告设计可以快速方便地交换车辆用户的自由裁量权，因为它们都使用共同的基本设计。 广告商可以向用户提供广告商产品的广告，以及与已经在用户车辆上的基座兼容的板。 本发明提供了一种新颖的方式让个人通过为新的和已建立的品牌和市场创造漫游广告来宣传他们的喜好，并为组织提供新颖的方式来吸引消费者的注意。