公开(公告)号：US20140044005A1

公开(公告)日：2014-02-13

申请号：US13353880

申请日：2012-01-19

申请人： Samuel Joseph Keys ,  Ernest William Brown ,  Alexander Chernyakhovsky ,  Adrian Harris Warren

发明人： Samuel Joseph Keys ,  Ernest William Brown ,  Alexander Chernyakhovsky ,  Adrian Harris Warren

IPC分类号： H04W16/22

CPC分类号： H04W16/225 ,  H04W16/18 ,  H04W24/08 ,  H04W24/10

摘要： A system for conducting wireless site surveys of a wireless environment is provided. A wireless interface controller controls a wireless interface during a scan of a wireless frequency band. A user interface module receives a set of wireless network design criteria, and a measurement module obtains a set of wireless signal information based on a set of wireless signals received during the scan of the wireless frequency band. An analysis module compares the set of wireless signal information to the set of wireless network design criteria and automatically determines whether the set of wireless network design criteria is, at least in part, satisfied. The user interface module provides an indicator that indicates whether the set of wireless network design criteria is, at least in part, satisfied.

摘要翻译： 提供了一种用于进行无线环境的无线站点调查的系统。 无线接口控制器在扫描无线频带期间控制无线接口。 用户接口模块接收一组无线网络设计标准，并且测量模块基于在无线频带的扫描期间接收的一组无线信号来获得一组无线信号信息。 分析模块将无线信号信息集合与无线网络设计标准集合进行比较，并自动确定无线网络设计标准是否至少部分满足。 用户接口模块提供指示器，其指示该组无线网络设计标准是否至少部分地满足。

公开(公告)号：US20120329662A1

公开(公告)日：2012-12-27

申请号：US13517411

申请日：2010-12-22

申请人： Catharine West ,  Crispin Miller ,  Adrian Harris ,  Francesca Buffa

发明人： Catharine West ,  Crispin Miller ,  Adrian Harris ,  Francesca Buffa

IPC分类号： C12Q1/68 ,  C40B40/06 ,  C40B30/00

CPC分类号： C12Q1/6886 ,  C12Q1/6809 ,  C12Q2600/106 ,  C12Q2600/118

摘要： The present invention relates to a method for assessing a hypoxia phenotype of a tumour of a subject in which the gene expression of between 3 and 50 hypoxia-related genes of a sample obtained from said tumour of the subject is determined, thereby obtaining a sample expression profile of said hypoxia-related genes. The sample gene expression profile is then compared with a reference expression profile of said hypoxia-related genes. The hypoxia-related genes comprise at least SLC2A1, VEGFA and PGAM1. Probes, arrays and kits for use in the method are also disclosed.

摘要翻译： 本发明涉及一种用于评价受试者的肿瘤的缺氧表型的方法，其中测定从所述受试者的所述肿瘤获得的样品的3至50个缺氧相关基因的基因表达，由此获得样品表达 所述缺氧相关基因的概况。 然后将样品基因表达谱与所述缺氧相关基因的参考表达谱进行比较。 缺氧相关基因至少包含SLC2A1，VEGFA和PGAM1。 还公开了用于该方法的探针，阵列和试剂盒。

公开(公告)号：US20060084123A1

公开(公告)日：2006-04-20

申请号：US11166997

申请日：2005-06-24

申请人： Adrian Harris ,  Peter Ratcliffe ,  Dirk Vordermark

发明人： Adrian Harris ,  Peter Ratcliffe ,  Dirk Vordermark

IPC分类号： G01N33/574

CPC分类号： C12Q1/527 ,  G01N33/573 ,  G01N33/574

摘要： The MN/CA IX protein is identified herein as a hypoxia marker. The MN/CA9 gene promoter is characterized, and the location of the HIF-1 binding site within the MN/CA9 promoter is identified. Further, the hypoxia inducibility of the MN/CA9 gene and the uses of such inducibility are disclosed. In one aspect, the invention provides diagnostic/prognostic tools for determining the presence of hypoxia in a tissue in a vertebrate, preferably a human, and for measuring the relative degree of hypoxia in said vertebrate. In another aspect, the invention provides methods using tumor biopsies to predict the radioresistance of a preneoplastic/neoplastic tissue in a vertebrate subject, preferably a human patient, for diseases in which MN/CA IX levels can be used to indicate radiobiologically relevant tumor hypoxia. Such predictive methods can be used as an aid in patient therapy selection.

摘要翻译： 本文将MN / CA IX蛋白质鉴定为缺氧标记。 表征MN / CA9基因启动子，鉴定MN / CA9启动子内HIF-1结合位点的位置。 此外，公开了MN / CA9基因的缺氧诱导能力和这种诱导性的用途。 一方面，本发明提供用于确定脊椎动物，优选人类的组织中缺氧的存在并用于测量所述脊椎动物中的相对缺氧程度的诊断/预后工具。 在另一方面，本发明提供了使用肿瘤活组织检查来预测脊椎动物受试者，优选人类患者中对于其中可以使用MN / CA IX水平来表示放射生物学相关的肿瘤缺氧的疾病的肿瘤前/肿瘤组织的放射抗性的方法。 这种预测方法可用作患者治疗选择的辅助。

公开(公告)号：US08685401B2

公开(公告)日：2014-04-01

申请号：US13524396

申请日：2012-06-15

申请人： Adrian Harris ,  Stanley Liu ,  Ruth Muschel

发明人： Adrian Harris ,  Stanley Liu ,  Ruth Muschel

IPC分类号： A61K39/395

CPC分类号： C07K16/28 ,  A61K41/0038 ,  A61K2039/505

摘要： The disclosure provides methods of treating cancer, tumors, and neoplasias by administering ionizing radiation and an anti-DLL4 antibody or a DLL4-binding fragment.

摘要翻译： 本公开提供了通过施用电离辐射和抗DLL4抗体或DLL4结合片段来治疗癌症，肿瘤和赘生物的方法。

公开(公告)号：US20130006034A1

公开(公告)日：2013-01-03

申请号：US13524396

申请日：2012-06-15

申请人： Adrian HARRIS ,  Stanley Liu ,  Ruth Muschel

发明人： Adrian HARRIS ,  Stanley Liu ,  Ruth Muschel

IPC分类号： A61K39/395 ,  A61N5/10 ,  A61P35/00

CPC分类号： C07K16/28 ,  A61K41/0038 ,  A61K2039/505

摘要： The disclosure provides methods of treating cancer, tumors, and neoplasias by administering ionizing radiation and an anti-DLL4 antibody or a DLL4-binding fragment.

摘要翻译： 本公开提供了通过施用电离辐射和抗DLL4抗体或DLL4结合片段来治疗癌症，肿瘤和赘生物的方法。

公开(公告)号：US20060188981A1

公开(公告)日：2006-08-24

申请号：US11356568

申请日：2006-02-17

申请人： Adrian Harris ,  Peter Ratcliffe

发明人： Adrian Harris ,  Peter Ratcliffe

IPC分类号： C12N15/63

CPC分类号： G01N33/57492 ,  G01N2333/988 ,  G01N2800/52

摘要： Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked by organic or inorganic molecules, preferably organic molecules, more preferably proteins/polypeptides that specifically bind to that site. Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Vectors are provided that encode the variable domains of MN-specific antibodies and a flexible linker polypeptide separating those domains. Further vectors are disclosed that encode a cytotoxic protein/polypeptide operatively linked to the MN gene promoter or a MN gene promoter fragment comprising the HIF-1 consensus binding sequence, and which vectors preferably further encode a cytokine. The MN gene promoter is characterized, and the binding site for a repressor of MN transcription is disclosed. Further, the hypoxia inducibility of the MN gene and the uses of such induciblity inducibility are disclosed.

摘要翻译： 本文所确定的是MN蛋白结合位点的位置，以及用固定的MN蛋白竞争与脊椎动物细胞附着的MN蛋白质/多肽。 这样的MN蛋白/多肽防止细胞粘附和细胞间接触的形成。 MN蛋白结合位点是可被有机或无机分子，优选有机分子，更优选特异性结合该位点的蛋白质/多肽阻断的治疗靶标。 公开了抑制异常表达MN蛋白的肿瘤前/肿瘤脊椎动物细胞生长的治疗方法。 提供编码MN-特异性抗体的可变结构域的载体和分离这些结构域的柔性接头多肽。 公开了编码与MN基因启动子或包含HIF-1共有结合序列的MN基因启动子片段有效连接的细胞毒性蛋白质/多肽的其它载体，并且哪些载体优选进一步编码细胞因子。 表征MN基因启动子，并公开MN转录抑制子的结合位点。 此外，公开了MN基因的缺氧诱导能力和这种可诱导性诱导性的用途。