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公开(公告)号：US20170022554A1
公开(公告)日：2017-01-26
申请号：US15136780
申请日：2016-04-22
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev
IPC: C12Q1/68
CPC classification number: C12Q1/6869 , C12N15/1065 , C12Q1/6806 , C12Q2525/204 , C12Q2525/301 , C12Q2535/122 , C12Q2563/179 , C12Q2521/507
Abstract: This disclosure provides methods and compositions for tagging long fragments of a target nucleic acid for sequencing and analyzing the resulting sequence information in order to reduce errors and perform haplotype phasing, for example.
Abstract translation: 本公开提供了用于标记靶核酸的长片段的方法和组合物，用于测序和分析所得到的序列信息，以便例如减少错误并进行单倍型定相。
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公开(公告)号：US09328382B2
公开(公告)日：2016-05-03
申请号：US14205145
申请日：2014-03-11
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev
CPC classification number: C12Q1/6869 , C12N15/1065 , C12Q1/6806 , C12Q2525/204 , C12Q2525/301 , C12Q2535/122 , C12Q2563/179 , C12Q2521/507
Abstract: This disclosure provides methods and compositions for tagging long fragments of a target nucleic acid for sequencing and analyzing the resulting sequence information in order to reduce errors and perform haplotype phasing, for example.
Abstract translation: 本公开提供了用于标记靶核酸的长片段的方法和组合物，用于测序和分析所得到的序列信息，以便例如减少错误并进行单倍型定相。
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公开(公告)号：US20140323316A1
公开(公告)日：2014-10-30
申请号：US14205145
申请日：2014-03-11
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev
IPC: C12Q1/68
CPC classification number: C12Q1/6869 , C12N15/1065 , C12Q1/6806 , C12Q2525/204 , C12Q2525/301 , C12Q2535/122 , C12Q2563/179 , C12Q2521/507
Abstract: This disclosure provides methods and compositions for tagging long fragments of a target nucleic acid for sequencing and analyzing the resulting sequence information in order to reduce errors and perform haplotype phasing, for example.
Abstract translation: 本公开提供了用于标记靶核酸的长片段的方法和组合物，用于测序和分析所得到的序列信息，以便例如减少错误并进行单倍型定相。
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公开(公告)号：US20250027147A1
公开(公告)日：2025-01-23
申请号：US18768640
申请日：2024-07-10
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev
IPC: C12Q1/6869 , C12N15/10 , C12Q1/6806
Abstract: The present invention provides methods and compositions for tagging long fragments of a target nucleic acid for sequencing and analyzing the resulting sequence information in order to reduce errors and perform haplotype phasing, for example.
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Patent Agency Ranking
公开(公告)号：US20240287598A1
公开(公告)日：2024-08-29
申请号：US18487926
申请日：2023-10-16
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev
IPC: C12Q1/6869 , C12N15/10 , C12Q1/6806
CPC classification number: C12Q1/6869 , C12Q1/6806 , C12N15/1065 , C12Q2525/204
Abstract: This disclosure provides methods and compositions for tagging long fragments of a target nucleic acid for sequencing and analyzing the resulting sequence information in order to reduce errors and perform haplotype phasing, for example.
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公开(公告)号：US10468121B2
公开(公告)日：2019-11-05
申请号：US14503872
申请日：2014-10-01
Applicant: Complete Genomics, Inc.
Inventor： Bahram Ghaffarzadeh Kermani , Radoje Drmanac , Brock A. Peters
Abstract: Long fragment read techniques can be used to identify deletions and resolve base calls by utilizing shared labels (e.g., shared aliquots) of a read with any reads corresponding to heterozygous loci (hets) of a haplotype. For example, the linking of a locus to a haplotype of multiple hets can increase the reads available at the locus for determining a base call for a particular haplotype. For a hemizygous deletion, a region can be linked to one or more hets, and the labels for a particular haplotype can be used to identify which reads in the region correspond to which haplotype. In this manner, since the reads for a particular haplotype can be identified, a hemizygous deletion can be determined. Further, a phasing rate of pulses can be used to identify large deletions. A deletion can be identified with the phasing rate is sufficiently low, and other criteria can be used.
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公开(公告)号：US10023910B2
公开(公告)日：2018-07-17
申请号：US15136780
申请日：2016-04-22
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev
IPC: C40B20/00 , C40B50/06 , C12Q1/68 , C07H21/02 , C12Q1/6869 , C12Q1/6806 , C12N15/10
Abstract: This disclosure provides methods and compositions for tagging long fragments of a target nucleic acid for sequencing and analyzing the resulting sequence information in order to reduce errors and perform haplotype phasing, for example.
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18.发明申请公开(公告)号：US20170120213A1
公开(公告)日：2017-05-04
申请号：US15289407
申请日：2016-10-10
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev , Peter Hong
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2219/00722 , C12P19/34 , C12Q1/6869 , C12Q1/6874 , C12Q2525/101 , C12Q2521/101
Abstract: The present invention is directed to methods and compositions for long fragment read sequencing. The present invention encompasses methods and compositions for preparing long fragments of genomic DNA, for processing genomic DNA for long fragment read sequencing methods, as well as software and algorithms for processing and analyzing sequence data.
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公开(公告)号：US09499863B2
公开(公告)日：2016-11-22
申请号：US14028319
申请日：2013-09-16
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev , Peter Hong
CPC classification number: B01J19/0046 , B01J2219/00722 , C12P19/34 , C12Q1/6869 , C12Q1/6874 , C12Q2525/101 , C12Q2521/101
Abstract: The present invention is directed to methods and compositions for long fragment read sequencing. The present invention encompasses methods and compositions for preparing long fragments of genomic DNA, for processing genomic DNA for long fragment read sequencing methods, as well as software and algorithms for processing and analyzing sequence data.
Abstract translation: 本发明涉及用于长片段读取测序的方法和组合物。 本发明包括用于制备基因组DNA长片段的方法和组合物，用于处理长片段读取测序方法的基因组DNA，以及用于处理和分析序列数据的软件和算法。
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