-
公开(公告)号：US20190002970A1
公开(公告)日：2019-01-03
申请号：US15993418
申请日：2018-05-30
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev
IPC: C12Q1/6869
Abstract: This disclosure provides methods and compositions for tagging long fragments of a target nucleic acid for sequencing and analyzing the resulting sequence information in order to reduce errors and perform haplotype phasing, for example.
-
公开(公告)号：US20160046985A1
公开(公告)日：2016-02-18
申请号：US14782307
申请日：2014-03-17
Applicant: COMPLETE GENOMICS, INC.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev
IPC: C12Q1/68
Abstract: The present invention provides methods and compositions for tagging long fragments of a target nucleic acid for sequencing and analyzing the resulting sequence information in order to reduce errors and perform haplotype phasing, for example.
Abstract translation: 本发明提供了用于标记靶核酸的长片段的方法和组合物，用于测序和分析所得到的序列信息，以便例如减少错误并进行单倍型定相。
-
公开(公告)号：US20160378916A1
公开(公告)日：2016-12-29
申请号：US15195741
申请日：2016-06-28
Applicant: Complete Genomics, Inc.
Inventor： Radoje T. Drmanac , Brock A. Peters , Bahram Ghaffarzadeh Kermani
CPC classification number: G16B30/00 , C12Q1/6869 , C12Q2537/159 , C12Q2549/10
Abstract: The present invention is directed to logic for analysis of nucleic acid sequence data that employs algorithms that lead to a substantial improvement in sequence accuracy and that can be used to phase sequence variations, e.g., in connection with the use of the long fragment read (LFR) process.
Abstract translation: 本发明涉及用于分析核酸序列数据的逻辑，其使用导致序列精度的实质性改进并且可用于相序变化的算法，例如结合使用长片段读取（LFR ）过程。
-
公开(公告)号：US20150094961A1
公开(公告)日：2015-04-02
申请号：US14503872
申请日：2014-10-01
Applicant: Complete Genomics, Inc.
Inventor： Bahram Ghaffarzadeh Kermani , Radoje Drmanac , Brock A. Peters
IPC: G06F19/22
Abstract: Long fragment read techniques can be used to identify deletions and resolve base calls by utilizing shared labels (e.g., shared aliquots) of a read with any reads corresponding to heterozygous loci (hets) of a haplotype. For example, the linking of a locus to a haplotype of multiple hets can increase the reads available at the locus for determining a base call for a particular haplotype. For a hemizygous deletion, a region can be linked to one or more hets, and the labels for a particular haplotype can be used to identify which reads in the region correspond to which haplotype. In this manner, since the reads for a particular haplotype can be identified, a hemizygous deletion can be determined. Further, a phasing rate of pulses can be used to identify large deletions. A deletion can be identified with the phasing rate is sufficiently low, and other criteria can be used.
Abstract translation: 可以使用长片段读取技术来识别缺失并通过利用与单倍型的杂合位点（hets）相对应的任何读取的共享标签（例如共享等分试样）来解析基本调用。 例如，将一个基因座与多个单倍型的单倍型的连接可以增加在该位点处可用的读数，以确定特定单体型的碱基调用。 对于半合子缺失，区域可以连接到一个或多个疱疹，并且特定单元型的标签可用于鉴定区域中哪个读取对应于哪个单倍型。 以这种方式，由于可以鉴定特定单体型的读数，所以可以确定半合子缺失。 此外，可以使用脉冲的相位速率来识别大的缺失。 可以通过相位速率来确定删除，并且可以使用其他标准。
-
公开(公告)号：US20140005056A1
公开(公告)日：2014-01-02
申请号：US14028319
申请日：2013-09-16
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev , Peter Hong
IPC: C12Q1/68
CPC classification number: B01J19/0046 , B01J2219/00722 , C12P19/34 , C12Q1/6869 , C12Q1/6874 , C12Q2525/101 , C12Q2521/101
Abstract: The present invention is directed to methods and compositions for long fragment read sequencing. The present invention encompasses methods and compositions for preparing long fragments of genomic DNA, for processing genomic DNA for long fragment read sequencing methods, as well as software and algorithms for processing and analyzing sequence data.
Abstract translation: 本发明涉及用于长片段读取测序的方法和组合物。 本发明包括用于制备基因组DNA长片段的方法和组合物，用于处理长片段读取测序方法的基因组DNA，以及用于处理和分析序列数据的软件和算法。
-
Patent Agency Ranking
公开(公告)号：US20220362735A1
公开(公告)日：2022-11-17
申请号：US17840843
申请日：2022-06-15
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev , Peter Hong
IPC: B01J19/00 , C12P19/34 , C12Q1/6869 , C12N15/10 , C12Q1/6874
Abstract: This disclosure provides methods and compositions for long fragment read sequencing. Technology is described for preparing long fragments of genomic DNA, for processing genomic DNA for long fragment read sequencing methods, as well as software and algorithms for processing and analyzing sequence data. Combinatorial oligonucleotide bar codes are used to label fragments from nearby portions of the genome, which facilitate computational assembly of sequence reads to obtain the genome sequence. This improves efficiency and accuracy of sequencing, whereby an entire sequence can be obtained from fragments that constitute a lower coverage amount of the genome.
-
公开(公告)号：US10557166B2
公开(公告)日：2020-02-11
申请号：US14782307
申请日：2014-03-17
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev
IPC: C40B20/00 , C40B50/06 , C12Q1/68 , C07H21/02 , C12Q1/6869 , C12Q1/6806 , C12N15/10
Abstract: The present invention provides methods and compositions for tagging long fragments of a target nucleic acid for sequencing and analyzing the resulting sequence information in order to reduce errors and perform haplotype phasing, for example.
-
公开(公告)号：US20190002969A1
公开(公告)日：2019-01-03
申请号：US15936123
申请日：2018-03-26
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev
IPC: C12Q1/6869
Abstract: The present invention provides methods and compositions for tagging long fragments of a target nucleic acid for sequencing and analyzing the resulting sequence information in order to reduce errors and perform haplotype phasing, for example.
-
公开(公告)号：US12071659B2
公开(公告)日：2024-08-27
申请号：US15936123
申请日：2018-03-26
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev
IPC: C12Q1/6869 , C12N15/10 , C12Q1/6806
CPC classification number: C12Q1/6869 , C12Q1/6806 , C12N15/1065 , C12Q2525/204 , C12Q1/6806 , C12Q2525/301 , C12Q2535/122 , C12Q2563/179 , C12Q1/6869 , C12Q2525/301 , C12Q2535/122 , C12Q2563/179 , C12Q1/6869 , C12Q2521/507
Abstract: The present invention provides methods and compositions for tagging long fragments of a target nucleic acid for sequencing and analyzing the resulting sequence information in order to reduce errors and perform haplotype phasing, for example.
-
公开(公告)号：US20180355421A9
公开(公告)日：2018-12-13
申请号：US14782307
申请日：2014-03-17
Applicant: COMPLETE GENOMICS, INC.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev
IPC: C12Q1/68
Abstract: The present invention provides methods and compositions for tagging long fragments of a target nucleic acid for sequencing and analyzing the resulting sequence information in order to reduce errors and perform haplotype phasing, for example.
-
-
-
-
-
-
-
-
-
Search Results
19
records
(took 0.02 seconds)
