公开(公告)号：US20240209132A1

公开(公告)日：2024-06-27

申请号：US18556213

申请日：2022-04-26

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Rolf KUENZI ,  Thomas NETSCHER

IPC: C08F232/06 ,  C08F2/06 ,  C08F4/32 ,  C08F4/44

CPC classification number: C08F232/06 ,  C08F2/06 ,  C08F4/32 ,  C08F4/44

Abstract: The present invention relates to the formation of compound of the formula (I) by reacting 2,3,6-trimethylhydroquinone or a protected derivative thereof with the unsaturated alcohol of formula (IIIa) or (IIIb) in the presence of Gd(OTf)3 or Tm(OTf)3 or Al(OTf)3 or Y(OTf)3 or Fe(OTf)2 or camphorsulfonic acid or BiCl3 as acidic catalyst.

公开(公告)号：US20240010607A1

公开(公告)日：2024-01-11

申请号：US18253124

申请日：2021-11-09

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Alexander GAA ,  Ralph HAERTER

IPC: C07C227/18

CPC classification number: C07C227/18

Abstract: The present invention relates to a process for producing L-phenylalanine ester which comprises the reaction of L-phenylalanine with an alcohol in the presence of thionyl chloride.

公开(公告)号：US20230192605A1

公开(公告)日：2023-06-22

申请号：US17915998

申请日：2021-03-22

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Marc-André MUELLER ,  Bettina WUESTENBERG

IPC: C07C403/02

CPC classification number: C07C403/02 ,  C07C2601/16

Abstract: The present invention relates to a new process for the production of specific intermediates, which are preferably used in the production of vitamin A and/or vitamin A acetate.

公开(公告)号：US20230068017A1

公开(公告)日：2023-03-02

申请号：US17788237

申请日：2020-12-15

Applicant: DSM IP Assets B.V.

Inventor： Werner BONRATH ,  Marc-André MUELLER ,  Bettina WUESTENBERG ,  Viktor ZIMMERMANN

IPC: C07C47/225 ,  C07C45/00

Abstract: The present invention relates to a new compound and the dehydrogenation of that compound to produce retinal.

公开(公告)号：US20230067679A1

公开(公告)日：2023-03-02

申请号：US17787794

申请日：2020-12-15

Applicant: DSM IP Assets B.V.

Inventor： Werner BONRATH ,  Felix IMBERI ,  Marc-André MUELLER ,  Bettina WUESTENBERG

IPC: C07C403/08

Abstract: The present invention relates to the functionalisation of specific 1,3-alpha-dienes (by hydroboration). These functionalized 1,3-alpha-dienes are important intermediates in organic synthesis (especially in the synthesis of carotenoids, vitamin A and/or vitamin A derivatives).

公开(公告)号：US20220204445A1

公开(公告)日：2022-06-30

申请号：US17603184

申请日：2020-04-03

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Marc-André MUELLER ,  Bettina WUESTENBERG ,  Viktor ZIMMERMANN

IPC: C07C403/14

Abstract: The present invention relates to a new process for the production of retinal or hydrogenated form of retinal.

公开(公告)号：US20210108234A1

公开(公告)日：2021-04-15

申请号：US16500497

申请日：2018-04-06

Applicant: DSM IP Assets B.V.

Inventor： Werner BONRATH ,  Martin SCHÜRMANN ,  Michele TAVANTI ,  Fabio PARMEGGIANI ,  Nicholas TURNER ,  Andrea MATTEVI ,  Jose Ruben CASSTELLANOS

IPC: C12P7/26 ,  C12N9/02

Abstract: The present invention relates to novel process for the production of ketoisophorone via biocatalytic conversion of isophorone, in particular a one-pot biocatalytic system for conversion of α-isophorone in a two-step oxidation process, with a first oxidation being catalyzed by a heme containing oxidoreductase such as a cytochrome P450 monooxygenase followed by another oxidation which can be either a chemical reaction or a biocatalytic reaction, in particular wherein the oxidation is catalyzed by an NAD(P) or NADP(H)-dependent oxidoreductase. The invention further provides polypeptides and nucleic acid sequences coding for cytochrome P450 monooxygenase with modified (higher) substrate selectivity, total turnover numbers and/or (re)activity compared to the wild-type enzyme. Ketoisophorone is useful as building block in the synthesis of vitamins and carotenoids.

公开(公告)号：US20210040119A1

公开(公告)日：2021-02-11

申请号：US17080516

申请日：2020-10-26

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Kun PENG ,  Lei ZHANG ,  Zhibin ZHU

IPC: C07D513/04 ,  C07D495/04

Abstract: The present invention provides a new process for the preparation of a substituted imidazothiazolone compound. The process of the present invention uses a fluoride-free Lewis acid which is cheap and friendly to environment, and provides high selectivity and yield.

公开(公告)号：US20200283368A1

公开(公告)日：2020-09-10

申请号：US16645614

申请日：2018-09-13

Applicant: DSM IP ASSETS B.V.

Inventor： Raphael BEUMER ,  Werner BONRATH ,  Marc-André MUELLER ,  Bettina WÜESTENBERG

IPC: C07C67/293

Abstract: The present invention relates to the compound of formula (I). The invention further relates to the compound of formula (II). The invention further relates to the synthesis of these compounds as well as to their use in organic synthesis, especially in the synthesis of vitamin A or p-carotene and derivatives thereof, e.g. canthaxanthin, astaxanthin or zeaxanthin.

公开(公告)号：US20200277244A1

公开(公告)日：2020-09-03

申请号：US16645589

申请日：2018-09-13

Applicant: DSM IP ASSETS B.V.

Inventor： Raphael BEUMER ,  Werner BONRATH ,  Marc-André MUELLER ,  Bettina WÜESTENBERG

IPC: C07C1/213

Abstract: The present invention relates to a process for the production of β-springene of formula (I) wherein a compound of formula (II) is heated in the presence of a catalyst.