公开(公告)号：US20240217941A1

公开(公告)日：2024-07-04

申请号：US18557241

申请日：2022-04-26

Applicant: DSM IP Assets B.V.

Inventor： Werner BONRATH ,  Rolf KUENZI ,  Meltem TIRPANCI ,  Thomas NETSCHER

IPC: C07D311/72 ,  C07D311/92

CPC classification number: C07D311/72 ,  C07D311/92

Abstract: The present invention relates to the formation of compound of the formula (I) by a ring closure reaction of the compound of the formula (II) in the presence of a catalytic amounts of a base. It has been found that this reaction is very efficient and offers for example an efficient pathway for the synthesis of 3,4-dehydro-α-tocotrienol respectively α-tocotrienol and α-tocopherol.

公开(公告)号：US20230142429A1

公开(公告)日：2023-05-11

申请号：US17915448

申请日：2021-03-22

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Marc-André MUELLER ,  Bettina WUESTENBERG ,  Viktor ZIMMERMANN

IPC: C07D333/48

CPC classification number: C07D333/48

Abstract: The present invention relates to a new process for the production of new specific intermediates, which are preferably used in the production of vitamin A, vitamin A acetate, or β-carotene and derivatives thereof, e.g. canthaxanthin, astaxanthin or zeaxanthin.

公开(公告)号：US20220204434A1

公开(公告)日：2022-06-30

申请号：US17603177

申请日：2020-04-03

Applicant: DSM IP ASSETS B.V.

Inventor： Fabrice AQUINO ,  Werner BONRATH ,  Marc-André MUELLER ,  Bettina WUESTENBERG

IPC: C07C49/21 ,  C07C45/67

Abstract: The application relates to a process for the preparation of a compound of formula (II) by cyclisation of a polyene of formula (I), and to an intermediate of formula (III). The obtained compounds are useful intermediates in the preparation of specific isoprenoids, preferably in the production of vitamin A and derivatives of vitamin A.

公开(公告)号：US20200061573A1

公开(公告)日：2020-02-27

申请号：US16609606

申请日：2018-05-01

Applicant: DSM IP ASSETS B.V.

Inventor： Marco ALTHEIMER ,  Werner BONRATH ,  Roman GOY ,  Jonathan Alan MEDLOCK ,  Sergio VERNUCCIO ,  Philipp RUDOLF VON ROHR

IPC: B01J19/24 ,  B01J19/00 ,  B01D46/24

Abstract: The present invention relates to a device for treatment of material transported through the device having a specific design.

公开(公告)号：US20190144365A1

公开(公告)日：2019-05-16

申请号：US16300269

申请日：2017-05-11

Applicant: DSM IP ASSETS B.V.

Inventor： Matthias BELLER ,  Werner BONRATH ,  Johannes Gerardus DE VRIES ,  Yuting FAN ,  Sandra HÜBNER ,  Laurent LEFORT ,  Jonathan Alan MEDLOCK ,  Pim PUYLAERT ,  Richard VAN HECK

IPC: C07C29/149 ,  B01J31/18 ,  B01J31/22 ,  B01J31/24

CPC classification number: C07C29/149 ,  B01J31/0212 ,  B01J31/1805 ,  B01J31/181 ,  B01J31/226 ,  B01J31/24 ,  B01J31/2404 ,  B01J2231/643 ,  B01J2531/0258 ,  B01J2531/821 ,  B01J2531/825 ,  B01J2531/842 ,  B01J2531/845 ,  C07C31/125 ,  C07C33/14 ,  C07C33/22 ,  C07C33/32 ,  C07C2601/16 ,  C07C31/20

Abstract: The present invention relates to a selective reduction of esters to their corresponding alcohols.

公开(公告)号：US20170313655A1

公开(公告)日：2017-11-02

申请号：US15518383

申请日：2015-10-15

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Jan SCHUETZ ,  Thomas NETSCHER ,  Bettina WUESTENBERG

IPC: C07C403/14

CPC classification number: C07C403/14 ,  C07C29/42 ,  C07C45/512 ,  C07C2601/16 ,  C07C33/14 ,  C07C47/225

Abstract: The present invention relates to an improved method for producing specific α,β-unsaturated aldehydes.

公开(公告)号：US20170297984A1

公开(公告)日：2017-10-19

申请号：US15518080

申请日：2015-10-15

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Jan SCHUETZ ,  Thomas NETSCHER ,  Bettina WUESTENBERG

IPC: C07C29/38 ,  C07C2601/16

CPC classification number: C07C29/38 ,  C07C29/42 ,  C07C403/08 ,  C07C2601/16 ,  C07C33/048

Abstract: The present invention relates to a catalytic process for the ethynylation of specific poly-unsaturated aldehydes and ketones.

公开(公告)号：US20160185683A1

公开(公告)日：2016-06-30

申请号：US14652562

申请日：2013-12-18

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Thomas NETSCHER ,  Jonathan Alan MEDLOCK ,  Gerardus Karel Maria VERZIJL ,  Andreas Hendrikus Maria DE VRIES

IPC: C07B35/02 ,  C07C41/48 ,  B01J31/18 ,  C07D317/12 ,  C07D319/06 ,  C07C41/56 ,  C07C41/58

CPC classification number: C07B35/02 ,  B01J31/189 ,  B01J2231/34 ,  B01J2531/827 ,  C07B53/00 ,  C07B2200/07 ,  C07B2200/09 ,  C07C41/48 ,  C07C41/56 ,  C07C41/58 ,  C07D311/72 ,  C07D317/12 ,  C07D319/06 ,  C07C43/303 ,  C07C43/313

Abstract: The present invention relates to a process of the asymmetric hydrogenation of a ketal of an unsaturated ketone or an acetal of an unsaturated aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex. This process yields chiral compounds in a very efficient way and is very advantageous in that the amount of iridium complex can be remarkably reduced.

Abstract translation: 本发明涉及在至少一种手性铱络合物的存在下，通过分子氢在不饱和酮或不饱和醛的缩醛中缩酮的不对称氢化的方法。 该方法以非常有效的方式产生手性化合物，并且非常有利的是铱络合物的量可以显着降低。

公开(公告)号：US20150329451A1

公开(公告)日：2015-11-19

申请号：US14647636

申请日：2013-11-28

Applicant: DSM IP ASSETS B.V.

Inventor： Raphael BEUMER ,  Werner BONRATH ,  Jonathan Alan MEDLOCK

IPC: C07C29/17

CPC classification number: C07C29/172 ,  C07C29/10 ,  C07C29/103 ,  C07C31/125

Abstract: The present invention relates to a new and improved synthesis of tetrahydromyrcenol (IUPAC name: 2,6-dimethyl-2-octanol).

Abstract translation: 本发明涉及四氢月桂烯醇（IUPAC名称：2,6-二甲基-2-辛醇）的新的和改进的合成。

公开(公告)号：US20150321986A1

公开(公告)日：2015-11-12

申请号：US14652339

申请日：2013-12-18

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Thomas NETSCHER ,  Jonathan Alan MEDLOCK ,  René Tobias STEMMLER ,  Gerardus Karel Maria VERZIJL ,  Andreas Hendrikus Maria DE VRIES

IPC: C07C45/62 ,  C07C50/14 ,  C07D311/58 ,  C07C45/82 ,  C07C43/303

CPC classification number: C07C45/62 ,  C07B2200/07 ,  C07B2200/09 ,  C07C43/303 ,  C07C45/82 ,  C07C50/14 ,  C07D311/58 ,  C07C49/203 ,  C07C49/04 ,  C07C47/02

Abstract: The present invention relates to a process of manufacturing compound having stereogenic centres from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centres. The process involves two asymmetric hydrogenation steps. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way.

Abstract translation: 本发明涉及由具有前手性双键的不饱和化合物的E / Z异构体的混合物制造具有立体中心化合物的方法。 氢化产物在立体中心处具有特定的所需构型。 该方法涉及两个不对称氢化步骤。 该方法非常有利，因为它以有效的方式从起始产物的立体异构体的混合物形成所需的手性产物。