公开(公告)号：US07546165B2

公开(公告)日：2009-06-09

申请号：US11305925

申请日：2005-12-19

申请人： Paul E. Zarembo ,  Mohan Krishnan ,  David Durand

发明人： Paul E. Zarembo ,  Mohan Krishnan ,  David Durand

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  H01R13/18 ,  H01R2201/12 ,  Y10T29/49117

摘要： An implantable lead comprises a lead body extending from a lead proximal end portion to a lead distal end portion. The lead body includes one or more longitudinally extending lumens. A conductor is received in, and extends along, a lumen. In varying examples, the implantable lead further comprises a tubular electrode co-axial with, and overlying portions of, the lead body. In one example, a lumen wall is sized and shaped to urge an electrically conductive interposer coupled with the conductor toward an inner surface of the electrode. In another example, a ring member is disposed within a lumen and the conductor is drawn and coupled thereto. In yet another example, an electrically conductive connector couples a first and a second conductor via grooves or threads. In a further example, an axial support member couples a distal end electrode and the lead body. Methods associated with the foregoing are also discussed.

摘要翻译： 可植入引线包括从引线近端部分延伸到引线远端部分的引线体。 引线体包括一个或多个纵向延伸的腔。 导体被容纳在内腔中并沿着其延伸。 在可变示例中，可植入引线还包括与引线主体同轴并且覆盖引线主体的部分的管状电极。 在一个示例中，腔壁的尺寸和形状被设计成将与导体耦合的导电插入件推向电极的内表面。 在另一示例中，环构件设置在管腔内并且导体被拉伸并与其连接。 在又一示例中，导电连接器通过凹槽或螺纹将第一和第二导体连接。 在另一示例中，轴向支撑构件将远端电极和引线体联接。 还讨论了与前述相关的方法。

公开(公告)号：US20070142890A1

公开(公告)日：2007-06-21

申请号：US11305925

申请日：2005-12-19

申请人： Paul Zarembo ,  Mohan Krishnan ,  David Durand

发明人： Paul Zarembo ,  Mohan Krishnan ,  David Durand

IPC分类号： A61N1/00

CPC分类号： A61N1/056 ,  H01R13/18 ,  H01R2201/12 ,  Y10T29/49117

摘要： An implantable lead comprises a lead body extending from a lead proximal end portion to a lead distal end portion. The lead body includes one or more longitudinally extending lumens. A conductor is received in, and extends along, a lumen. In varying examples, the implantable lead further comprises a tubular electrode co-axial with, and overlying portions of, the lead body. In one example, a lumen wall is sized and shaped to urge an electrically conductive interposer coupled with the conductor toward an inner surface of the electrode. In another example, a ring member is disposed within a lumen and the conductor is drawn and coupled thereto. In yet another example, an electrically conductive connector couples a first and a second conductor via grooves or threads. In a further example, an axial support member couples a distal end electrode and the lead body. Methods associated with the foregoing are also discussed.

摘要翻译： 可植入引线包括从引线近端部分延伸到引线远端部分的引线体。 引线体包括一个或多个纵向延伸的腔。 导体被容纳在内腔中并沿着其延伸。 在可变示例中，可植入引线还包括与引线主体同轴并且覆盖引线主体的部分的管状电极。 在一个示例中，腔壁的尺寸和形状被设计成将与导体耦合的导电插入件推向电极的内表面。 在另一示例中，环构件设置在管腔内并且导体被拉伸并与其连接。 在又一示例中，导电连接器通过凹槽或螺纹将第一和第二导体连接。 在另一示例中，轴向支撑构件将远端电极和引线体联接。 还讨论了与前述相关的方法。

公开(公告)号：US06564107B1

公开(公告)日：2003-05-13

申请号：US09642802

申请日：2000-08-21

申请人： Jeff Bodner ,  Mohan Krishnan

发明人： Jeff Bodner ,  Mohan Krishnan

IPC分类号： A61N100

CPC分类号： A61N1/056 ,  A61N1/05

摘要： A lead body for use with medical devices and method for lead body manufacture are provided. The lead body defines a lumen. The lumen has an electrically conductive material deposited on the lumen wall. The lead body's manufacture includes coating a lumen wall of a lead body with a conductive material to provide a conductor between the proximal and distal ends of the lead body. The manufacture further includes fitting sleeves electrically connected to electrical elements within the lumen to provide an electrical connection between the sleeve and the conductive material.

摘要翻译： 提供了一种用于医疗器械的引线体和用于引线体制造的方法。 引线体定义管腔。 内腔具有沉积在管腔壁上的导电材料。 引线体的制造包括用导电材料涂覆引线主体的管腔壁，以在引线主体的近端和远端之间提供导体。 该制造还包括电连接到管腔内的电气元件的套筒，以在套管和导电材料之间提供电连接。

公开(公告)号：US5616671A

公开(公告)日：1997-04-01

申请号：US632291

申请日：1996-04-15

申请人： Ramani Narayan ,  Philippe Dubois ,  Mohan Krishnan

发明人： Ramani Narayan ,  Philippe Dubois ,  Mohan Krishnan

IPC分类号： C08B31/04 ,  C08G63/664 ,  C08L3/06 ,  C08L67/04 ,  C08L101/00 ,  C08G16/00

CPC分类号： C08L67/04 ,  C08B31/04 ,  C08G63/664 ,  C08L101/00 ,  C08L3/06

摘要： Novel synthetic pathways to derive aliphatic polyester-grafted polysaccharides from cyclic ester monomers, preferably, poly(.epsilon.-caprolactone) and starch. Different reaction schemes lead to compositions with various levels of grafting. The grafting reactions were conducted using bulk monomer and an organometallic polymerization agent (catalyst or initiator) such as metal alkoxides initiators which were generated in-situ by the reaction of metal alkyls with hydroxyl groups of the polysaccharide. The grafting reactions were characterized by very fast reaction times of the order of a few minutes to effect complete conversion of monomer. Biodegradable compositions, particularly using these poly(.epsilon.-caprolactone)-grafted starch are described for use in film applications.

摘要翻译： 从环酯单体，优选聚（ε-己内酯）和淀粉衍生脂族聚酯接枝多糖的新型合成途径。 不同的反应方案导致具有各种水平的接枝的组合物。 接枝反应使用本体单体和有机金属聚合剂（催化剂或引发剂）如金属醇盐引发剂进行，其通过金属烷基与多糖的羟基的反应原位产生。 接枝反应的特征是非常快的几分钟的反应时间以实现单体的完全转化。 特别是使用这些聚（ε-己内酯）移植淀粉的生物可降解组合物被描述用于膜应用中。

公开(公告)号：US08594792B2

公开(公告)日：2013-11-26

申请号：US13690068

申请日：2012-11-30

申请人： Lili Liu ,  Mohan Krishnan ,  Bruce A Tockman ,  David R. Wulfman

发明人： Lili Liu ,  Mohan Krishnan ,  Bruce A Tockman ,  David R. Wulfman

IPC分类号： A61N1/365

CPC分类号： A61N1/36564 ,  A61M25/0041 ,  A61M2025/0002 ,  A61M2205/3344 ,  A61N1/056 ,  A61N1/3627 ,  A61N1/36585 ,  A61N2001/0585

摘要： A cardiac rhythm management system comprises a medical electrical lead, a pressure sensing element, and an implantable pulse generator. The lead is sized to be advanced through the right atrium and coronary sinus into a coronary vein adjacent to the left ventricle. The lead includes an opening intermediate its proximal and distal ends, and a lumen extending longitudinally within the body in communication with the opening. The pressure sensing element is movably disposed in lead lumen and is dimensioned to extend through the opening in the lead, and includes a flexible, elongated conductive member having a distal end, and a pressure transducer coupled to the distal end of the conductive member. The pulse generator is configured to receive cardiac rhythm signals from the electrode and fluid pressure signals from the pressure transducer.

摘要翻译： 心律管理系统包括医疗电引线，压力感测元件和可植入脉冲发生器。 铅的大小可以通过右心房和冠状窦进入与左心室相邻的冠状静脉。 引线包括在其近端和远端之间的开口，以及在主体内与开口连通的纵向延伸的内腔。 压力感测元件可移动地设置在引导腔中，并且其尺寸设计成延伸穿过引线中的开口，并且包括具有远端的柔性细长导电构件和耦合到导电构件的远端的压力传感器。 脉冲发生器被配置为从电极接收心律信号和来自压力传感器的流体压力信号。

公开(公告)号：US08055354B2

公开(公告)日：2011-11-08

申请号：US12467978

申请日：2009-05-18

申请人： Paul E. Zarembo ,  Mohan Krishnan ,  David Durand

发明人： Paul E. Zarembo ,  Mohan Krishnan ,  David Durand

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  H01R13/18 ,  H01R2201/12 ,  Y10T29/49117

摘要： An implantable lead comprises a lead body extending from a lead proximal end portion to a lead distal end portion. The lead body includes one or more longitudinally extending lumens. A conductor is received in, and extends along, a lumen. In varying examples, the implantable lead further comprises a tubular electrode co-axial with, and overlying portions of, the lead body. In one example, a lumen wall is sized and shaped to urge an electrically conductive interposer coupled with the conductor toward an inner surface of the electrode. In another example, a ring member is disposed within a lumen and the conductor is drawn and coupled thereto. In yet another example, an electrically conductive connector couples a first and a second conductor via grooves or threads. In a further example, an axial support member couples a distal end electrode and the lead body. Methods associated with the foregoing are also discussed.

摘要翻译： 可植入引线包括从引线近端部分延伸到引线远端部分的引线体。 引线体包括一个或多个纵向延伸的腔。 导体被容纳在内腔中并沿着其延伸。 在可变示例中，可植入引线还包括与引线主体同轴并且覆盖引线主体的部分的管状电极。 在一个示例中，腔壁的尺寸和形状被设计成将与导体耦合的导电插入件推向电极的内表面。 在另一示例中，环构件设置在管腔内并且导体被拉伸并与其连接。 在又一示例中，导电连接器通过凹槽或螺纹将第一和第二导体连接。 在另一示例中，轴向支撑构件将远端电极和引线体联接。 还讨论了与前述相关的方法。

公开(公告)号：US20100114285A1

公开(公告)日：2010-05-06

申请号：US12686035

申请日：2010-01-12

申请人： Rebecca Aron ,  Mohan Krishnan ,  Kevin Ely

发明人： Rebecca Aron ,  Mohan Krishnan ,  Kevin Ely

IPC分类号： A61N1/02

CPC分类号： A61N1/0565 ,  A61N1/056 ,  A61N1/0563 ,  B29C65/022 ,  B29C65/1412 ,  B29C65/16 ,  B29C65/7473 ,  B29K2023/06 ,  B29K2105/04 ,  B29K2105/256 ,  B29L2009/00 ,  B29L2031/753

摘要： This document discusses, among other things, a lead assembly including a porous polyethylene cover. In an example, the cover includes sections that have differing pore sizes. In an example, a section of the cover near a distal end portion of a lead assembly includes pores that are large enough to allow tissue ingrowth. In another example, a lead assembly includes two or more polyethylene covers having different porosities.

摘要翻译： 本文件尤其涉及包括多孔聚乙烯盖的引线组件。 在一个示例中，盖包括具有不同孔径的部分。 在一个示例中，在铅组件的远端部分附近的一部分盖包括足够大以允许组织向内生长的孔。 在另一个示例中，引线组件包括具有不同孔隙率的两个或更多个聚乙烯盖。

公开(公告)号：US20090125059A1

公开(公告)日：2009-05-14

申请号：US12265282

申请日：2008-11-05

申请人： Kevin E. Verzal ,  Adam J. Rivard ,  Mohan Krishnan ,  G. Shantanu Reddy ,  Patsy A. Coppola ,  Edward L. Dickinson ,  Andrew C. Harvey

发明人： Kevin E. Verzal ,  Adam J. Rivard ,  Mohan Krishnan ,  G. Shantanu Reddy ,  Patsy A. Coppola ,  Edward L. Dickinson ,  Andrew C. Harvey

IPC分类号： A61N1/05 ,  A61B17/00

CPC分类号： A61N1/057 ,  A61N2001/0582

摘要： An implantable medical system includes a medical lead including an insulating sheath and a conductor and an anchoring device. The anchoring device defines an inner lumen adapted to coaxially receive the medical lead, where the inner lumen has an effective diameter. The anchoring device includes a sleeve including a substantially elongate body defining an outer surface and an inner bore. The anchoring device also has a compression member including a first end, a second end, and an intermediate portion between the first and second ends. The compression member is at least partially embedded in the sleeve such that compression of the first and second ends of the compression member toward one another causes the effective diameter of at least a portion of the inner lumen of the anchoring device to reversibly increase.

摘要翻译： 可植入医疗系统包括包括绝缘护套和导体的医疗引线和锚定装置。 锚定装置限定适于同轴地接纳医疗引线的内腔，其中内腔具有有效直径。 锚固装置包括套筒，其包括限定外表面和内孔的基本上细长的主体。 锚定装置还具有包括第一端部，第二端部和第一端部和第二端部之间的中间部分的压缩构件。 压缩构件至少部分地嵌入在套筒中，使得压缩构件的第一和第二端部彼此朝向彼此的压缩导致锚定装置的内腔的至少一部分的有效直径可逆地增加。

公开(公告)号：US20070123965A1

公开(公告)日：2007-05-31

申请号：US11643224

申请日：2006-12-21

申请人： Randy Westlund ,  Mohan Krishnan ,  Avram Scheiner

发明人： Randy Westlund ,  Mohan Krishnan ,  Avram Scheiner

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N2001/0578 ,  A61N2001/0585

摘要： A medical electrical lead employs a load bearing sleeve arrangement. A medical electrical lead includes an outer sleeve, having proximal and distal ends, and is formed of a first material. At least one electrical conductor is situated within the outer sleeve and extends between the proximal and distal ends of the outer sleeve. At least one electrode is electrically coupled to the electrical conductor. A load bearing sleeve extends between the proximal and distal ends of the outer sleeve. The load bearing sleeve is formed of a second material different from the first material. The load bearing sleeve offers resistance to axial loading forces applied to the lead. The load bearing sleeve can be coextensive with the outer sleeve or extend along at least the majority of the length of the outer sleeve.

摘要翻译： 医用电线使用承载套筒装置。 医用电线包括具有近端和远端的外套，并由第一材料形成。 至少一个电导体位于外套筒内并且在外套筒的近端和远端之间延伸。 至少一个电极电耦合到电导体。 承载套筒在外套筒的近端和远端之间延伸。 承载套筒由不同于第一材料的第二材料形成。 承载套筒提供抵抗施加到引线的轴向载荷力。 承载套筒可以与外套筒共同延伸或者沿外套筒的至少大部分长度延伸。

公开(公告)号：US20060129217A1

公开(公告)日：2006-06-15

申请号：US11349002

申请日：2006-02-07

申请人： Mohan Krishnan

发明人： Mohan Krishnan

IPC分类号： A61N1/05

CPC分类号： A61N1/0563

摘要： An implantable lead includes a distal portion carrying a tissue stimulating electrode, at least a portion of its outer surface being adapted to stimulate cardiac tissue, wherein the electrode is covered by a pliable, electrically conductive sheath. The sheath is made of an electrically conductive material that does not rely on porosity for electrical charge transfer. The sheath is constructed and arranged to minimize or eliminate tissue ingrowth while passing sufficient electrical energy to stimulate the tissue.