公开(公告)号：US20060237335A1

公开(公告)日：2006-10-26

申请号：US11388811

申请日：2006-03-24

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Giovanni Rodriguez

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Giovanni Rodriguez

IPC: A45C11/04

CPC classification number: A45C11/005 ,  Y10S134/901

Abstract: A contact lens container includes a body defining a cavity that is sized to hold a contact lens. A stopper is in fluid communication with the cavity and the stopper includes a resealable portion that is received into a channel. The resealable portion has a predetermined wall thickness in an axial direction thereof, the resealable portion defines a needle penetration region that is pierceable with a needle to form a needle aperture therethrough, and is heat resealable to hermetically seal the needle aperture.

Abstract translation: 隐形眼镜容器包括限定腔体的主体，其尺​​寸被设计成保持隐形眼镜。 止动器与空腔流体连通，并且止动件包括接收到通道中的可重新密封部分。 可重新密封的部分在其轴向上具有预定的壁厚，可重新密封部分限定了用针刺穿的针穿透区域，以形成穿过其中的针孔，并且是可热再密封的，以密封针孔。

公开(公告)号：US20140246462A1

公开(公告)日：2014-09-04

申请号：US14101981

申请日：2013-12-10

Applicant: Daniel Py ,  Julian V. Chan ,  Benoit Adamo ,  Nathaniel Houle

Inventor： Daniel Py ,  Julian V. Chan ,  Benoit Adamo ,  Nathaniel Houle

IPC: B65D37/00

CPC classification number: B67D1/108 ,  B05B11/00444 ,  B65B39/004 ,  B65D51/002 ,  B65D51/1616 ,  B67D1/0004 ,  B67D1/0007 ,  B67D1/0009 ,  B67D1/0082 ,  B67D1/0801 ,  B67D1/10 ,  B67D1/1279 ,  B67D3/0067 ,  B67D3/04 ,  B67D2001/0827 ,  F04B53/1037

Abstract: A flexible pouch and valve assembly is provided for aseptically storing a substance, dispensing multiple portions of the stored substance therefrom, and maintaining substance remaining in the pouch in an aseptic condition sealed with respect to ambient atmosphere. The flexible pouch and valve assembly are receivable within a relatively rigid housing, and are adapted to cooperate with a pump for pumping discrete portions of substance from the pouch and through the one-way valve to dispense the substance therefrom. The assembly comprises a flexible pouch defining therein a variable-volume storage chamber sealed with respect to the ambient atmosphere for aseptically storing therein multiple portions of the substance. A one-way valve of the assembly includes a valve body defining an axially-extending valve seat and at least one flow aperture extending through the valve body and/or the valve seat.

Abstract translation: 提供了一种柔性袋和阀组件，用于无菌存储物质，从其中分配多部分储存物质，并将残留在袋中的物质保持在相对于环境大气密封的无菌状态。 柔性袋和阀组件可接收在相对刚性的壳体内，并且适于与泵协作，用于泵送物质的离散部分并且通过单向阀从其分配物质。 组件包括柔性袋，其中限定有相对于环境大气密封的可变容积存储室，用于将物质的多个部分无菌存储。 组件的单向阀包括限定轴向延伸的阀座的阀体和延伸穿过阀体和/或阀座的至少一个流动孔。

公开(公告)号：US08602259B2

公开(公告)日：2013-12-10

申请号：US13362532

申请日：2012-01-31

Applicant: Daniel Py ,  Julian V. Chan ,  Benoit Adamo ,  Nathaniel Houle

Inventor： Daniel Py ,  Julian V. Chan ,  Benoit Adamo ,  Nathaniel Houle

IPC: B67D7/14

CPC classification number: B67D1/108 ,  B05B11/00444 ,  B65B39/004 ,  B65D51/002 ,  B65D51/1616 ,  B67D1/0004 ,  B67D1/0007 ,  B67D1/0009 ,  B67D1/0082 ,  B67D1/0801 ,  B67D1/10 ,  B67D1/1279 ,  B67D3/0067 ,  B67D3/04 ,  B67D2001/0827 ,  F04B53/1037

Abstract: A flexible pouch and valve assembly is provided for aseptically storing a substance, dispensing multiple portions of the stored substance therefrom, and maintaining substance remaining in the pouch in an aseptic condition sealed with respect to ambient atmosphere. The flexible pouch and valve assembly are receivable within a relatively rigid housing, and are adapted to cooperate with a pump for pumping discrete portions of substance from the pouch and through the one-way valve to dispense the substance therefrom. The assembly comprises a flexible pouch defining therein a variable-volume storage chamber sealed with respect to the ambient atmosphere for aseptically storing therein multiple portions of the substance. A one-way valve of the assembly includes a valve body defining an axially-extending valve seat and at least one flow aperture extending through the valve body and/or the valve seat.

公开(公告)号：US08181431B2

公开(公告)日：2012-05-22

申请号：US13012074

申请日：2011-01-24

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  M. Jeffrey Willey

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  M. Jeffrey Willey

IPC: B65B3/02 ,  B65B5/02

CPC classification number: B65B3/022

Abstract: Apparatus for molding and filling a device having a body defining an opening in communication with an interior chamber for receiving a substance therein, and a closure including a penetrable and resealable portion for sealing the opening and substance received in the device. A mold includes within the aseptic chamber plural mold cavities shaped to form the closure and body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the body and closure is movable relative to the mold to engage and de-mold the substantially sterile closures and bodies from the mold cavities. Flexible barriers are coupled to the mold and the tool to substantially prevent the passage of contaminants from the molding machine and tool therethrough.

Abstract translation: 用于模制和填充具有本体的装置的装置，该主体限定与用于在其中容纳物质的内部腔室连通的开口;以及封闭件，包括用于密封容纳在装置中的开口和物质的可穿透和可重新密封的部分。 模具包括在无菌室内的多个模具腔，其形状形成封闭件和主体，以及基本上无菌的表面，其围绕并邻近模具腔的周边延伸。 包括端臂工具的组装装置具有可与主体和闭合件中的每一个接合的接合部分，其可相对于模具移动以将基本无菌的闭合件和主体与模腔接合和脱模。 柔性屏障耦合到模具和工具，以基本上防止污染物从模制机器和工具通过。

公开(公告)号：US08071009B2

公开(公告)日：2011-12-06

申请号：US11582291

申请日：2006-10-17

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Giovanni Rodriguez

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Giovanni Rodriguez

IPC: B29C45/04

CPC classification number: B29C45/1701 ,  B29C37/0007 ,  B29C45/006 ,  B29C45/1753 ,  B29C45/40 ,  B29C45/42 ,  B29C2045/1797 ,  B29C2791/005

Abstract: An apparatus and method are provided for molding sterile parts. The apparatus has a first mold portion and a second mold portion. At least one of the first and second mold portions defines a mold cavity configured to receive a molten plastic and form therefrom at least one molded part At least one of the first and second mold portions is movable relative to the other between (i) a closed position for sealing the mold cavity or cavities and molding at least one part therein, and (ii) an open position defining a fluid passageway between the first and second mold portions and permitting the passage of a fluid sterilant therein. A fluid source that contains or otherwise generates a fluid sterilant, such as vaporized hydrogen peroxide, is connectable in fluid communication with the fluid passageway for introducing the sterilant into the fluid passageway with at least one of the first and second mold portions in the open position, and in turn contacting with the sterilant the surfaces of the first and second mold portions forming the fluid passageway and located adjacent to the at least one mold cavity, but not contacting an interior surface of a molded part within the mold cavity, to sterilize the exposed mold surfaces and thereby prevent contamination of the molded part.

Abstract translation: 提供了用于模制无菌部件的装置和方法。 该装置具有第一模具部分和第二模具部分。 第一模具部分和第二模具部分中的至少一个限定了模腔，其被配置为容纳熔融塑料并从其形成至少一个模制部件。第一模具部分和第二模具部分中的至少一个可相对于彼此移动， 用于密封模腔或空腔并在其中模制至少一个部件的位置，以及（ii）限定第一和第二模具部分之间的流体通道并允许其中的流体灭菌剂通过的打开位置。 包含或以其它方式产生流体灭菌剂的流体源例如蒸发的过氧化氢可连接到流体通道，用于将灭菌剂引入流体通道，其中第一和第二模具部分中的至少一个处于打开位置 并且又与灭菌剂接触形成第一和第二模具部分的表面，形成流体通道并且位于与至少一个模具腔相邻但不与模具腔内的模制部件的内表面接触，以消毒 暴露的模具表面，从而防止模制部件的污染。

公开(公告)号：US20110113729A1

公开(公告)日：2011-05-19

申请号：US13012074

申请日：2011-01-24

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  M. Jeffrey Willey

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  M. Jeffrey Willey

IPC: B65B55/02 ,  B65B47/00 ,  B65B5/02

CPC classification number: B65B3/022

Abstract: Apparatus for molding and filling a device having a body defining an opening in communication with an interior chamber for receiving a substance therein, and a closure including a penetrable and resealable portion for sealing the opening and substance received in the device. A mold includes within the aseptic chamber plural mold cavities shaped to form the closure and body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the body and closure is movable relative to the mold to engage and de-mold the substantially sterile closures and bodies from the mold cavities. Flexible barriers are coupled to the mold and the tool to substantially prevent the passage of contaminants from the molding machine and tool therethrough.

Abstract translation: 用于模制和填充具有本体的装置的装置，该主体限定与用于在其中容纳物质的内部腔室连通的开口;以及封闭件，包括用于密封容纳在装置中的开口和物质的可穿透和可重新密封的部分。 模具包括在无菌室内的多个模具腔，其形状形成封闭件和主体，以及基本上无菌的表面，其围绕并邻近模具腔的周边延伸。 包括端臂工具的组装装置具有可与主体和闭合件中的每一个接合的接合部分，其可相对于模具移动以将基本无菌的闭合件和主体与模腔接合和脱模。 柔性屏障耦合到模具和工具，以基本上防止污染物从模制机器和工具通过。

公开(公告)号：US20100276030A1

公开(公告)日：2010-11-04

申请号：US12627655

申请日：2009-11-30

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy

IPC: B67C3/24 ,  B65B3/04

CPC classification number: B65B3/006 ,  A61L2/10 ,  A61M5/1782 ,  B29C66/80 ,  B65B3/003 ,  B65B43/00 ,  B65B51/00 ,  Y10T29/49716

Abstract: An assembly includes a support and drive assembly, a first structure and a second structure. The first structure is in operable communication with and supported by the support and drive assembly. The first structure includes at least one needle assembly and is adjustable to receive a plurality of needle assemblies. The second structure is supported by the support and drive assembly. The second structure includes at least one seal assembly and is adjustable to receive a plurality of seal assemblies. A method includes determining a number of vials that are to be filled concurrently and adjusting an assembly to include at least one needle assembly and at least one seal assembly. A number of the needle assemblies and the seal assemblies equals the number of vials.

Abstract translation: 组件包括支撑和驱动组件，第一结构和第二结构。 第一结构与支撑和驱动组件可操作地连通并由其支撑。 第一结构包括至少一个针组件，并且可调节以接收多个针组件。 第二个结构由支撑和驱动组件支撑。 第二结构包括至少一个密封组件，并且可调节以接收多个密封组件。 一种方法包括确定要同时填充的小瓶的数量并且调整组件以包括至少一个针组件和至少一个密封组件。 许多针组件和密封组件等于小瓶的数量。

公开(公告)号：US20090145089A1

公开(公告)日：2009-06-11

申请号：US12371601

申请日：2009-02-14

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  M. Jeffrey Willey

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  M. Jeffrey Willey

IPC: B65B3/02 ,  B65B5/02 ,  B65B55/18 ,  B65B55/10

CPC classification number: B65B3/022

Abstract: Apparatus for molding and filling a device having a body defining an opening in communication with an interior chamber for receiving a substance therein, and a closure including a penetrable and resealable portion for sealing the opening and substance received in the device. A mold includes within the aseptic chamber plural mold cavities shaped to form the closure and body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the body and closure is movable relative to the mold to engage and de-mold the substantially sterile closures and bodies from the mold cavities. Flexible barriers are coupled to the mold and the tool to substantially prevent the passage of contaminants from the molding machine and tool therethrough.

Abstract translation: 用于模制和填充具有本体的装置的装置，该主体限定与用于在其中容纳物质的内部腔室连通的开口;以及封闭件，包括用于密封容纳在装置中的开口和物质的可穿透和可重新密封的部分。 模具包括在无菌室内的多个模具腔，其形状形成封闭件和主体，以及基本上无菌的表面，其围绕并邻近模具腔的周边延伸。 包括端臂工具的组装装置具有可与主体和闭合件中的每一个接合的接合部分，其可相对于模具移动以将基本无菌的闭合件和主体与模腔接合和脱模。 柔性屏障耦合到模具和工具，以基本上防止污染物从模制机器和工具通过。

公开(公告)号：US20060169722A1

公开(公告)日：2006-08-03

申请号：US11295251

申请日：2005-12-05

Applicant: Daniel Py ,  Julian Chan ,  Benoit Adamo

Inventor： Daniel Py ,  Julian Chan ,  Benoit Adamo

IPC: B65D37/00

CPC classification number: B67D1/0004 ,  B65B39/004 ,  B67D1/0007 ,  B67D1/0009 ,  B67D1/0082 ,  B67D1/10 ,  B67D1/108 ,  B67D1/1279 ,  B67D3/04 ,  B67D2001/0827 ,  F04B43/1238 ,  F04B53/1037 ,  Y10T137/7761

Abstract: An apparatus has a valve body defining a first passageway, a valve seat, and a flow aperture extending through the valve body and coupled in fluid communication with the first passageway. A valve cover of the apparatus is formed of an elastic material and includes a cover base mounted on the valve body and fixedly secured against movement relative thereto, and a valve portion overlying the valve seat. The valve portion defines a predetermined radial thickness and forms an interference fit with the valve seat. The valve portion and the valve seat define a normally closed, axially-extending valve opening therebetween. The valve portion is movable between a normally closed position with the valve portion engaging the valve seat, and an open position with at least a segment of the valve portion spaced away from the valve seat to connect the valve opening in fluid communication with the flow aperture to thereby allow the passage of fluid from the flow aperture through the valve opening. A hermetically sealed variable-volume storage chamber stores therein multiple portions of the fluid and is connectible in fluid communication with the one-way valve assembly. A pump is coupled between the variable-volume storage chamber and the one-way valve assembly, and is configured to pump discrete portions of fluid from the variable-volume storage chamber, through the flow aperture, and through the valve opening to dispense the portions of fluid through the valve assembly.

Abstract translation: 一种装置具有限定第一通道，阀座和延伸穿过阀体并与第一通道流体连通地联接的流动孔的阀体。 该装置的阀盖由弹性材料形成，并且包括安装在阀体上的盖基座，并且固定地抵靠其相对移动，以及覆盖在阀座上的阀部分。 阀部分限定预定的径向厚度并与阀座形成过盈配合。 阀部分和阀座限定了其间的常闭的，轴向延伸的阀开口。 阀部分可以在与阀座接合的阀部分的常闭位置和打开位置之间移动，打开位置具有与阀座间隔开的阀部分的至少一段，以连接与开口流体连通的阀开口 从而允许流体从流动孔通过阀开口。 气密密封的可变容积储存室在其中存储有多个流体部分，并可与单向阀组件流体连通。 泵连接在可变容积存储室和单向阀组件之间，并且构造成从可变容积储存室通过流动孔泵送离散的流体部分，并且通过阀开口分配部分 的流体通过阀组件。

公开(公告)号：US20060151051A1

公开(公告)日：2006-07-13

申请号：US11295274

申请日：2005-12-05

Applicant: Daniel Py ,  Julian Chan ,  Benoit Adamo

Inventor： Daniel Py ,  Julian Chan ,  Benoit Adamo

IPC: B65B1/04

CPC classification number: B67D1/0004 ,  B65B39/004 ,  B67D1/0007 ,  B67D1/0009 ,  B67D1/0082 ,  B67D1/10 ,  B67D1/108 ,  B67D1/1279 ,  B67D3/04 ,  B67D2001/0827 ,  F04B43/1238 ,  F04B53/1037 ,  Y10T137/7761

Abstract: An apparatus has a valve body defining a first passageway, a valve seat, and a flow aperture extending through the valve body and coupled in fluid communication with the first passageway. A valve cover of the apparatus is formed of an elastic material and includes a cover base mounted on the valve body and fixedly secured against movement relative thereto, and a valve portion overlying the valve seat. The valve portion defines a predetermined radial thickness and forms an interference fit with the valve seat. The valve portion and the valve seat define a normally closed, axially-extending valve opening therebetween. The valve portion is movable between a normally closed position with the valve portion engaging the valve seat, and an open position with at least a segment of the valve portion spaced away from the valve seat to connect the valve opening in fluid communication with the flow aperture to thereby allow the passage of fluid from the flow aperture through the valve opening. A hermetically sealed variable-volume storage chamber stores therein multiple portions of the fluid and is connectible in fluid communication with the one-way valve assembly. A pump is coupled between the variable-volume storage chamber and the one-way valve assembly, and is configured to pump discrete portions of fluid from the variable-volume storage chamber, through the flow aperture, and through the valve opening to dispense the portions of fluid through the valve assembly.

Abstract translation: 一种装置具有限定第一通道，阀座和延伸穿过阀体并与第一通道流体连通地联接的流动孔的阀体。 该装置的阀盖由弹性材料形成，并且包括安装在阀体上的盖基座，并且固定地抵靠其相对移动，以及覆盖在阀座上的阀部分。 阀部分限定预定的径向厚度并与阀座形成过盈配合。 阀部分和阀座限定了其间的常闭的，轴向延伸的阀开口。 阀部分可以在与阀座接合的阀部分的常闭位置和打开位置之间移动，打开位置具有与阀座间隔开的阀部分的至少一段，以连接与开口流体连通的阀开口 从而允许流体从流动孔通过阀开口。 气密密封的可变容积储存室在其中存储有多个流体部分，并可与单向阀组件流体连通。 泵连接在可变容积存储室和单向阀组件之间，并且构造成从可变容积储存室通过流动孔泵送离散的流体部分，并且通过阀开口分配部分 的流体通过阀组件。