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公开(公告)号:US07893049B2
公开(公告)日:2011-02-22
申请号:US11696900
申请日:2007-04-05
申请人: Darryl McConnell , Bodo Betzemeier , Thomas Gerstberger , Maria Impagnatiello , Steffen Steurer , Lars van der Veen , Ulrike Weyer-Czernilofsky
发明人: Darryl McConnell , Bodo Betzemeier , Thomas Gerstberger , Maria Impagnatiello , Steffen Steurer , Lars van der Veen , Ulrike Weyer-Czernilofsky
IPC分类号: A61K31/00 , A61K31/44 , A61K31/445 , A61K31/497 , A61P43/00 , C07D211/32 , C07D217/00 , C07D279/10 , C07D401/00 , C07D413/00
CPC分类号: C07D513/04
摘要: The present invention encompasses compounds of general formula (1) wherein R1 to R6 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 6如权利要求1中所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病,以及其用于制备具有上述药物的药物的用途, 上述属性。
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公开(公告)号:US20130005736A1
公开(公告)日:2013-01-03
申请号:US13540865
申请日:2012-07-03
IPC分类号: A61K31/501 , A61P31/14
CPC分类号: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
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公开(公告)号:US07468388B2
公开(公告)日:2008-12-23
申请号:US11734394
申请日:2007-04-12
申请人: Betty Jin , Simon J. F. MacDonald , Darryl McConnell , Van T. T. Nguyen , Stephen E. Shanahan , Wen-Yang Wu
发明人: Betty Jin , Simon J. F. MacDonald , Darryl McConnell , Van T. T. Nguyen , Stephen E. Shanahan , Wen-Yang Wu
IPC分类号: A61K31/351
CPC分类号: A61K31/351 , A61K31/13 , A61K31/7056 , A61K38/00 , A61K45/06 , A61K47/54 , A61K47/55 , C07D309/28 , C07K5/06104 , A61K2300/00
摘要: The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, NHCO or O; n is an integer from 2 to 6; and Y is C2-C9 alkyl C3-8 cycloalkyl, C1-C4 alkoxyalkyl, an amino acid or dipeptide, or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.
摘要翻译: 本发明涉及通式(I)的化合物; 其中R是氨基或胍基; R2是乙酰基或三氟乙酰基; X是CONH,NHCO或O; n为2-6的整数; 并且Y是C 2 -C 9烷基C 3-8环烷基,C 1 -C 4烷氧基烷基,氨基酸或二肽或其药学上可接受的衍生物,其制备方法,含有它们的药物制剂或其用于预防或治疗病毒 感染。
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公开(公告)号:US08637549B2
公开(公告)日:2014-01-28
申请号:US13054245
申请日:2009-07-15
申请人: Harald Engelhardt , Guido Boehmelt , Christiane Kofink , Daniel Kuhn , Darryl McConnell , Heinz Stadtmueller
发明人: Harald Engelhardt , Guido Boehmelt , Christiane Kofink , Daniel Kuhn , Darryl McConnell , Heinz Stadtmueller
IPC分类号: A01N43/40 , A61K31/44 , C07D487/00
CPC分类号: C07D401/12 , C07D401/04 , C07D401/14 , C07D487/04
摘要: The present invention encompasses compounds of general formula (1) while the groups R4 to R7 and the units W, L, Qa and QH are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and their use as medicaments having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,而基团R4至R7和单元W,L,Qa和QH如权利要求1中所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病, 并且其用作具有上述性质的药物。
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公开(公告)号:US08624025B2
公开(公告)日:2014-01-07
申请号:US13540865
申请日:2012-07-03
IPC分类号: C07D401/14 , C07D403/14 , A61K31/4523 , A61P31/12
CPC分类号: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的衍生物,包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途,以及可用于制备式I化合物的新中间体。
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公开(公告)号:US20110269958A1
公开(公告)日:2011-11-03
申请号:US13054245
申请日:2009-07-15
申请人: Harald Engelhardt , Guido Boehmelt , Christiane Kofink , Daniel Kuhn , Darryl McConnell , Heinz Stadtmueller
发明人: Harald Engelhardt , Guido Boehmelt , Christiane Kofink , Daniel Kuhn , Darryl McConnell , Heinz Stadtmueller
IPC分类号: C07D413/14 , C07D401/14
CPC分类号: C07D401/12 , C07D401/04 , C07D401/14 , C07D487/04
摘要: The present invention encompasses compounds of general formula (1) while the groups R4 to R7 and the units W, L, Qa and QH are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use as medicaments having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,而基团R4至R7和单元W,L,Qa和QH如权利要求1中所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病, 并且其用作具有上述性质的药物。
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公开(公告)号:US07579465B2
公开(公告)日:2009-08-25
申请号:US11559242
申请日:2006-11-13
IPC分类号: C07D401/14 , C07D403/14 , A61K31/4523 , A61K31/53 , A61K31/506 , A61P31/12
CPC分类号: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的衍生物,包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途,以及可用于制备式I化合物的新中间体。
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公开(公告)号:US20070149531A1
公开(公告)日:2007-06-28
申请号:US11559253
申请日:2006-11-13
IPC分类号: A61K31/53 , A61K31/501 , A61K31/497 , C07D403/14 , C07D413/14 , C07D417/14
CPC分类号: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的衍生物,包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途,以及可用于制备式I化合物的新型中间体。
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公开(公告)号:US07223790B2
公开(公告)日:2007-05-29
申请号:US10494260
申请日:2002-11-08
申请人: Betty Jin , Simon J. F. MacDonald , Darryl McConnell , Van T. T. Nguyen , Stephen E. Shanahan , Wen-Yang Wu
发明人: Betty Jin , Simon J. F. MacDonald , Darryl McConnell , Van T. T. Nguyen , Stephen E. Shanahan , Wen-Yang Wu
IPC分类号: A61K31/35
CPC分类号: A61K31/351 , A61K31/13 , A61K31/7056 , A61K38/00 , A61K45/06 , A61K47/54 , A61K47/55 , C07D309/28 , C07K5/06104 , A61K2300/00
摘要: The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, NHCO or O; n is an integer from 2 to 6; and Y is C2–C8 alkyl C3-8 cycloalkyl, C1–C4 alkoxyalkyl, an amino acid or dipeptide, or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection
摘要翻译: 本发明涉及通式(I)的化合物; 其中R是氨基或胍基; R 2是乙酰基或三氟乙酰基; X是CONH,NHCO或O; n为2-6的整数; 且Y为C 2 -C 8烷基C 3-8环烷基,C 1 -C 3烷基, 4烷氧基烷基,氨基酸或二肽或其药学上可接受的衍生物,其制备方法,含有它们的药物制剂或其在预防或治疗病毒感染中的用途
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公开(公告)号:US07078403B1
公开(公告)日:2006-07-18
申请号:US10018963
申请日:2000-06-16
申请人: Wen-Yang Wu , Keith Watson , Darryl McConnell , Betty Jin , Guy Krippner
发明人: Wen-Yang Wu , Keith Watson , Darryl McConnell , Betty Jin , Guy Krippner
IPC分类号: A61K31/53
CPC分类号: C07D401/04 , C07D237/20 , C07D237/22 , C07D261/08 , C07D403/04 , C07D417/14
摘要: Disclosed herein are compounds of formula II: wherein Alk, Z, X1, X2, R1, —R10 and R11 are defined herein, and their salts and pharmaceutically acceptable derivatives thereof, as well as other compounds of the general formula Het-A-Alk-W-Ar-C(X2)═NO-X2 where Het, A, W and Ar are also defined herein. These compounds are useful in treating picornavirus infections in mammals. Novel intermediates of these compounds, as well as pharmaceutical compositions and methods of use, are also disclosed herein.
摘要翻译: 本文公开了式II的化合物:其中Alk,Z,X 1,X 2,R 1,R 10, 本文定义的本文及其盐及其药学上可接受的衍生物,以及通式Het-A-Alk-W-Ar-C(X
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