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公开(公告)号：US08637549B2
公开(公告)日：2014-01-28
申请号：US13054245
申请日：2009-07-15
申请人： Harald Engelhardt , Guido Boehmelt , Christiane Kofink , Daniel Kuhn , Darryl McConnell , Heinz Stadtmueller
发明人： Harald Engelhardt , Guido Boehmelt , Christiane Kofink , Daniel Kuhn , Darryl McConnell , Heinz Stadtmueller
IPC分类号： A01N43/40 , A61K31/44 , C07D487/00
CPC分类号： C07D401/12 , C07D401/04 , C07D401/14 , C07D487/04
摘要： The present invention encompasses compounds of general formula (1) while the groups R4 to R7 and the units W, L, Qa and QH are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and their use as medicaments having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，而基团R4至R7和单元W，L，Qa和QH如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 并且其用作具有上述性质的药物。
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公开(公告)号：US20110269958A1
公开(公告)日：2011-11-03
申请号：US13054245
申请日：2009-07-15
申请人： Harald Engelhardt , Guido Boehmelt , Christiane Kofink , Daniel Kuhn , Darryl McConnell , Heinz Stadtmueller
发明人： Harald Engelhardt , Guido Boehmelt , Christiane Kofink , Daniel Kuhn , Darryl McConnell , Heinz Stadtmueller
IPC分类号： C07D413/14 , C07D401/14
CPC分类号： C07D401/12 , C07D401/04 , C07D401/14 , C07D487/04
摘要： The present invention encompasses compounds of general formula (1) while the groups R4 to R7 and the units W, L, Qa and QH are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use as medicaments having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，而基团R4至R7和单元W，L，Qa和QH如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 并且其用作具有上述性质的药物。
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3.发明申请HETEROCYCLYL CARBONIC ACID AMIDES AS ANTIPROLIFERATIVE AGENTS, PDKL INHIBITORS 审中-公开作为抗增生剂的间苯二酚类碳酸钠，PDKL抑制剂公开(公告)号：US20110313156A1
公开(公告)日：2011-12-22
申请号：US13003973
申请日：2009-07-15
申请人： Harald Engelhardt , Guido Boehmelt , Christiane Kofink , Daniel Kuhn , Darryl McConnell , Heinz Stadtmueller
发明人： Harald Engelhardt , Guido Boehmelt , Christiane Kofink , Daniel Kuhn , Darryl McConnell , Heinz Stadtmueller
IPC分类号： C07D403/14 , C07D403/12 , C07D413/14
CPC分类号： C07D471/04 , C07D213/64 , C07D401/14 , C07D403/14
摘要： The present invention encompasses compounds of general formula (1) wherein the units W, A, L, Qa and QH are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use as medicaments having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中单元W，A，L，Qa和QH如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，其用途为 具有上述特性的药物。
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![1H-IMIDAZO[4,5-C]QUINOLINES](/abs-image/US/2013/08/15/US20130210832A1/abs.jpg.150x150.jpg)
公开(公告)号：US20130210832A1
公开(公告)日：2013-08-15
申请号：US13697034
申请日：2011-05-17
IPC分类号： C07D471/04 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/513 , A61K31/501
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/501 , A61K31/513 , A61K45/06
摘要： The present invention encompasses compounds of general formula (1), wherein the groups R1 to R7, Qa, Qb, L, n and m are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations containing such compounds and their use as medicaments.
摘要翻译： 本发明包括通式（1）的化合物，其中R1至R7，Qa，Qb，L，n和m基团如权利要求1中所定义，其适用于治疗特征为过度或异常细胞增殖的疾病 ，含有这些化合物的药物制剂及其作为药物的用途。
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公开(公告)号：US20120094976A1
公开(公告)日：2012-04-19
申请号：US13089614
申请日：2011-04-19
IPC分类号： A61K31/513 , C07D401/14 , C07D403/14 , C07D413/14 , C07D405/14 , A61K31/517 , A61K31/498 , A61K31/5377 , A61K31/501 , A61K31/4709 , A61P35/00 , A61P31/00 , A61P29/00 , A61P37/00 , C07D403/12
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, Qa, Qb, QH, L and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.
摘要翻译： 本发明包括通式（1）的化合物，其中基团R1至R4，Qa，Qb，QH，L和n如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 含有这些化合物的药物制剂及其作为药物的用途。
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![1H-imidazo[4,5-c]quinolines](/abs-image/US/2014/11/25/US08895581B2/abs.jpg.150x150.jpg)
公开(公告)号：US08895581B2
公开(公告)日：2014-11-25
申请号：US13697034
申请日：2011-05-17
IPC分类号： A61K31/437 , C07D471/04 , A61K31/501 , A61K45/06 , A61K31/444 , A61K31/513 , A61K31/4545
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/501 , A61K31/513 , A61K45/06
摘要： The present invention encompasses compounds of general formula (1), wherein the groups R1 to R7, Qa, Qb, L, n and m are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, pharmaceutical preparations containing such compounds and their use as medicaments.
摘要翻译： 本发明包括通式（1）的化合物，其中R1至R7，Qa，Qb，L，n和m基团如权利要求1中所定义，其适用于治疗特征为过度或异常细胞增殖的疾病 ，含有这些化合物的药物制剂及其作为药物的用途。
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公开(公告)号：US08575203B2
公开(公告)日：2013-11-05
申请号：US13089614
申请日：2011-04-19
IPC分类号： A61K31/44
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, Qa, Qb, QH, L and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.
摘要翻译： 本发明包括通式（1）的化合物，其中基团R1至R4，Qa，Qb，QH，L和n如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 含有这些化合物的药物制剂及其作为药物的用途。
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