公开(公告)号：US09346806B2

公开(公告)日：2016-05-24

申请号：US13272956

申请日：2011-10-13

申请人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

发明人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

IPC分类号： A61K31/522 ,  A61P11/06 ,  C07D473/18 ,  C07D473/16

CPC分类号： A61K31/522 ,  A61K9/0043 ,  A61K31/55 ,  A61K45/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C07D473/16 ,  C07D473/18

摘要： Compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

摘要翻译： 式（I）化合物：其中R 1是C 1-6烷基氨基，C 1-6烷氧基或C 3-7环烷氧基; m为3〜6的整数， n为0〜4的整数， 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。

公开(公告)号：US20120035193A1

公开(公告)日：2012-02-09

申请号：US13272956

申请日：2011-10-13

申请人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

发明人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

IPC分类号： A61K31/522 ,  A61P11/06

CPC分类号： A61K31/522 ,  A61K9/0043 ,  A61K31/55 ,  A61K45/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C07D473/16 ,  C07D473/18

摘要： Compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

摘要翻译： 式（I）化合物：其中R 1是C 1-6烷基氨基，C 1-6烷氧基或C 3-7环烷氧基; m为3〜6的整数， n为0〜4的整数， 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。

公开(公告)号：US20110144136A1

公开(公告)日：2011-06-16

申请号：US13058465

申请日：2009-08-07

申请人： Helene Bazin-Lee ,  Diane Mary Coe ,  Linos Lazarides ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

发明人： Helene Bazin-Lee ,  Diane Mary Coe ,  Linos Lazarides ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

IPC分类号： A61K31/522 ,  C07D473/18 ,  C07D473/16 ,  A61P29/00 ,  A61P37/08

CPC分类号： C07D473/16 ,  A61K31/522 ,  C07D473/18

摘要： The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, or C1-6alkoxy; R2 is a group having the structure: n is an integer having a value of 1 to 6; Het is a 6-membered saturated heterocycle containing one nitrogen atom wherein Het is attached to the —(CH2)n— moiety at any carbon atom of the heterocycle; R3 is hydrogen, C1-8alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

摘要翻译： 本发明涉及式（I）的化合物：其中R 1是C 1-6烷基氨基或C 1-6烷氧基; R2是具有以下结构的基团：n是具有1至6的整数; Het是含有一个氮原子的6元饱和杂环，其中Het与杂环的任何碳原子连接至 - （CH 2）n - 部分; R3是氢，C1-8烷基或C3-7环烷基C0-6烷基; 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。

公开(公告)号：US20110135671A1

公开(公告)日：2011-06-09

申请号：US13058489

申请日：2009-08-07

申请人： Helene Bazin-Lee ,  Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Naimisha Trivedi

发明人： Helene Bazin-Lee ,  Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Naimisha Trivedi

IPC分类号： A61K39/00 ,  C07D473/18 ,  C07D473/16 ,  A61K31/522 ,  A61P35/00 ,  A61P31/00 ,  A61P29/00 ,  A61P37/08 ,  A61P37/04

CPC分类号： C07D473/16 ,  C07D473/18

摘要： The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 2 to 6; R2 is hydrogen, C1-6alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

摘要翻译： 本发明涉及式（I）的化合物：其中R 1是C 1-6烷基氨基，C 1-6烷氧基或C 3-7环烷氧基; m为2〜6的整数; R 2是氢，C 1-6烷基或C 3-7环烷基C 1-6烷基; 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。

公开(公告)号：US08765772B2

公开(公告)日：2014-07-01

申请号：US13058470

申请日：2009-08-07

申请人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

发明人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

IPC分类号： A61K31/522 ,  C07D473/34

CPC分类号： A61K31/522 ,  A61K9/0043 ,  A61K31/55 ,  A61K45/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C07D473/16 ,  C07D473/18

摘要： The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

摘要翻译： 本发明涉及式（I）的化合物：其中R 1是C 1-6烷基氨基，C 1-6烷氧基或C 3-7环烷氧基; m为3〜6的整数， n为0〜4的整数， 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。

公开(公告)号：US08735390B2

公开(公告)日：2014-05-27

申请号：US13821585

申请日：2011-09-06

申请人： Julie Nicole Hamblin ,  Paul Spencer Jones ,  Suzanne Elaine Keeling ,  Joelle Le ,  Charlotte Jane Mitchell ,  Nigel James Parr ,  Robert David Willacy

发明人： Julie Nicole Hamblin ,  Paul Spencer Jones ,  Suzanne Elaine Keeling ,  Joelle Le ,  Charlotte Jane Mitchell ,  Nigel James Parr ,  Robert David Willacy

IPC分类号： A61K31/5377 ,  C07D413/14

CPC分类号： A61K31/5377 ,  C07D413/14

摘要： The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

摘要翻译： 本发明涉及作为激酶活性抑制剂的化合物的新型多晶型物和盐。

公开(公告)号：US08609657B2

公开(公告)日：2013-12-17

申请号：US13633230

申请日：2012-10-02

申请人： Julie Nicole Hamblin ,  Paul Spencer Jones ,  Suzanne Elaine Keeling ,  Joelle Le ,  Charlotte Jane Mitchell ,  Nigel James Parr

发明人： Julie Nicole Hamblin ,  Paul Spencer Jones ,  Suzanne Elaine Keeling ,  Joelle Le ,  Charlotte Jane Mitchell ,  Nigel James Parr

IPC分类号： A61K31/535 ,  C07D413/14

CPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/497 ,  A61K31/535 ,  A61K45/06 ,  C07B2200/13 ,  C07D413/14 ,  Y02A50/409

摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

公开(公告)号：US20130165441A1

公开(公告)日：2013-06-27

申请号：US13821585

申请日：2011-09-06

申请人： Julie Nicole Hamblin ,  Paul Spencer Jones ,  Suzanne Elaine Keeling ,  Joelle Le ,  Charlotte Jane Mitchell ,  Nigel James Parr ,  Robert David Willacy

发明人： Julie Nicole Hamblin ,  Paul Spencer Jones ,  Suzanne Elaine Keeling ,  Joelle Le ,  Charlotte Jane Mitchell ,  Nigel James Parr ,  Robert David Willacy

IPC分类号： C07D413/14

CPC分类号： A61K31/5377 ,  C07D413/14

摘要： The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

公开(公告)号：US09326987B2

公开(公告)日：2016-05-03

申请号：US13821594

申请日：2011-09-06

申请人： Julie Nicole Hamblin ,  Paul Spencer Jones ,  Suzanne Elaine Keeling ,  Joelle Le ,  Charlotte Jane Mitchell ,  Nigel James Parr

发明人： Julie Nicole Hamblin ,  Paul Spencer Jones ,  Suzanne Elaine Keeling ,  Joelle Le ,  Charlotte Jane Mitchell ,  Nigel James Parr

IPC分类号： A61K31/535 ,  A61K31/497 ,  A61K31/445 ,  A61K31/55 ,  A61K31/5377 ,  C07D413/14 ,  A61K31/416 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5386

CPC分类号： A61K31/5377 ,  A61K31/416 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5386 ,  C07D413/14

摘要： The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.

摘要翻译： 本发明涉及用于治疗或预防流感病毒感染的化合物。

公开(公告)号：US08575162B2

公开(公告)日：2013-11-05

申请号：US12768775

申请日：2010-04-28

申请人： Julie Nicole Hamblin ,  Paul Spencer Jones ,  Suzanne Elaine Keeling ,  Joelle Le ,  Charlotte Jane Mitchell ,  Nigel James Parr

发明人： Julie Nicole Hamblin ,  Paul Spencer Jones ,  Suzanne Elaine Keeling ,  Joelle Le ,  Charlotte Jane Mitchell ,  Nigel James Parr

IPC分类号： A61K31/535 ,  C07D413/14

CPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/497 ,  A61K31/535 ,  A61K45/06 ,  C07B2200/13 ,  C07D413/14 ,  Y02A50/409

摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.