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公开(公告)号：US08586590B2
公开(公告)日：2013-11-19
申请号：US13633320
申请日：2012-10-02
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
IPC分类号： A61K31/497 , C07D413/14
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是激酶活性的抑制剂，特别是PI3-激酶活性。
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公开(公告)号：US20130203772A1
公开(公告)日：2013-08-08
申请号：US13879667
申请日：2011-10-25
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr , Robert David Willacy
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr , Robert David Willacy
IPC分类号： C07D413/14
CPC分类号： C07D413/14
摘要： The present invention is directed to a polymorph of a compound and salts of a compound and polymorphs thereof, which compound is an inhibitor of kinase activity.
摘要翻译： 本发明涉及一种化合物和化合物的盐及其多晶型物的多晶型物，该化合物是激酶活性的抑制剂。
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公开(公告)号：US20130029985A1
公开(公告)日：2013-01-31
申请号：US13633230
申请日：2012-10-02
申请人： Julie Nicole HAMBLIN , Paul Spencer JONES , Suzanne Elaine KEELING , Joelle LE , Charlotte Jane MITCHELL , Nigel James PARR
发明人： Julie Nicole HAMBLIN , Paul Spencer JONES , Suzanne Elaine KEELING , Joelle LE , Charlotte Jane MITCHELL , Nigel James PARR
IPC分类号： A61K31/5377 , A61P37/06 , A61P31/12 , A61P11/00 , A61P29/00 , A61P9/00 , A61P13/12 , A61P7/02 , A61P35/00 , A61P25/00 , A61P25/28 , A61P9/10 , A61P17/00 , A61P11/06 , A61P37/08
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
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4.发明授权公开(公告)号：US08163743B2
公开(公告)日：2012-04-24
申请号：US12994246
申请日：2009-06-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
IPC分类号： C07D231/56 , C07D401/04 , A61K31/416 , A61K31/4439 , A61P11/00
CPC分类号： C07D231/56
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of P13-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是P13-激酶活性的抑制剂。
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![6-(1H-indol-4-yl)-4-(5-{[4-1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole hemi succinate salt, polymorphs and pharmaceutical compositions thereof](/abs-image/US/2015/03/31/US08993576B2/abs.jpg.150x150.jpg)
5.发明授权6-(1H-indol-4-yl)-4-(5-{[4-1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole hemi succinate salt, polymorphs and pharmaceutical compositions thereof 有权6-（1H-吲哚-4-基）-4-（5 - {[4-1-甲基乙基] -1-哌嗪基]甲基} -1,3-恶唑-2-基）-1H-吲唑半琥珀酸盐 ，多晶型物及其药物组合物公开(公告)号：US08993576B2
公开(公告)日：2015-03-31
申请号：US13879667
申请日：2011-10-25
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr , Robert David Willacy
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr , Robert David Willacy
IPC分类号： A61K31/496 , C07D413/14
CPC分类号： C07D413/14
摘要： The present invention is directed to a polymorph of a compound and salts of a compound and polymorphs thereof, which compound is an inhibitor of kinase activity.
摘要翻译： 本发明涉及一种化合物和化合物的盐及其多晶型物的多晶型物，该化合物是激酶活性的抑制剂。
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公开(公告)号：US08580797B2
公开(公告)日：2013-11-12
申请号：US12768777
申请日：2010-04-28
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
IPC分类号： A61K31/497 , C07D413/14
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
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公开(公告)号：US20100280045A1
公开(公告)日：2010-11-04
申请号：US12768777
申请日：2010-04-28
申请人： Julie Nicole HAMBLIN , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
发明人： Julie Nicole HAMBLIN , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
IPC分类号： A61K31/497 , C07D413/14 , A61P11/00 , A61P31/12 , A61P37/00 , A61P29/00 , A61P9/00 , A61P7/00 , A61P1/18 , A61P13/12 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular Pl3-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是激酶活性抑制剂，特别是PI3激酶活性。
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公开(公告)号：US20090181950A1
公开(公告)日：2009-07-16
申请号：US12300832
申请日：2007-05-17
IPC分类号： A61K31/55 , C07D401/14 , A61P29/00 , A61P37/08
CPC分类号： C07D215/54 , C07D215/48
摘要： The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis.
摘要翻译： 本发明涉及式（I）化合物及其盐，其制备方法，含有它们的组合物及其在治疗各种疾病如过敏性鼻炎中的用途。
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公开(公告)号：US08765743B2
公开(公告)日：2014-07-01
申请号：US12994253
申请日：2009-06-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号： A61K31/4439 , A61K31/5377 , A61K31/4545 , A61K31/496 , C07D401/14 , C07D413/14 , C07D405/14 , C07D471/04
CPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
摘要： The invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译： 本发明涉及式（I）的化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号：US08609657B2
公开(公告)日：2013-12-17
申请号：US13633230
申请日：2012-10-02
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
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