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公开(公告)号：US20070042370A1
公开(公告)日：2007-02-22
申请号：US10553650
申请日：2004-03-16
Applicant: Serguei Soukharev , David Hammond
Inventor： Serguei Soukharev , David Hammond
CPC classification number: C07F9/65522 , C07F9/6561 , C12Q1/42
Abstract: Disclosed are compounds of the formula (I): wherein R3, R4, R5, R9, and R10 are selected from the group consisting of H and groups or atoms other than H, and R6 and R8 are halo or hydrogen; X1, X2, and X3 are independently O or S; provided that R9 and R10 are not simultaneously H, when all of X1, X2, and X3 are O; and of the formula (II) wherein R11-R14 are selected from the group consisting of H and groups or atoms other than H; X4-X9 are independently O or S; n and m are 0 or 1 but m and n cannot be 0 simultaneously; R15-R24 can be H or any substituent so long as the compound of formula II upon hydrolysis provides a fluorescent compound. These compounds are useful as substrates with high specificity for organophosphatase particularly human paraoxonase and bacterial organophosphorus hydrolase. Also disclosed is a method for detecting and/or measuring the paraoxonase activity in a fluid comprising contacting the fluid with a fluorescent substrate and measuring the fluorescence of the fluorescent product formed.
Abstract translation: 公开了式（I）的化合物：其中R 3，R 4，R 5，R 9， 和R 10选自H和H以外的基团或原子，R 6和R 8是卤素或 氢; X 1，X 2，X 3和X 3独立地为O或S; 条件是当R 9和R 10均为H时，当X 1，X 2和X 2都全部时，R 9和R 10不同时为H， X 3是O; 和其中R 11 -R 14的式（II）选自H和H以外的基团或原子; X S 9 独立地是O或S; n和m是0或1，但m和n不能同时为0; 只要水解的式II化合物提供荧光化合物，R 15 -R 24可以是H或任何取代基。 这些化合物可用作对有机磷酸酶特别是人类对氧磷酶和细菌有机磷水解酶具有高特异性的底物。 还公开了一种用于检测和/或测量流体中对氧磷酶活性的方法，包括使流体与荧光底物接触并测量形成的荧光产物的荧光。
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公开(公告)号：US20060078892A1
公开(公告)日：2006-04-13
申请号：US10962670
申请日：2004-10-13
Applicant: David Hammond , Ruben Carbonell , Honglue Shen , Patrick Gurgel , Viterose Wiltshire-Lyerly , Steven Burton
Inventor： David Hammond , Ruben Carbonell , Honglue Shen , Patrick Gurgel , Viterose Wiltshire-Lyerly , Steven Burton
CPC classification number: B01J20/286 , B01J20/265 , B01J20/285 , B01J20/321 , B01J20/3219 , B01J20/3246 , B01J20/3248 , B01J20/3251 , B01J20/3257 , B01J20/3293 , B01J2220/54
Abstract: Prion protein binding materials and methods for using the binding materials to detect or remove a prion protein from a sample, such as a biological fluid or an environmental sample. The binding materials are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), recombinant prion protein (PrPr), and proteinase resistant prion protein (PrPres). Prions from various species, including humans and hamsters, are bound by the binding materials.
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13.发明授权Methods, systems, and computer readable media for stress testing mobile network equipment using a common public radio interface (CPRI) 有权使用公共无线电接口（CPRI）对移动网络设备进行压力测试的方法，系统和计算机可读介质公开(公告)号：US08229416B2
公开(公告)日：2012-07-24
申请号：US12337285
申请日：2008-12-17
Applicant: Arda Akman , Matthew Balkwill , David Hammond , Richard Karp , Edward Panofsky , Glenn Stewart , Kalyan Sundhar
Inventor： Arda Akman , Matthew Balkwill , David Hammond , Richard Karp , Edward Panofsky , Glenn Stewart , Kalyan Sundhar
IPC: H04W24/00
CPC classification number: H04W24/06 , H04L41/145 , H04L43/50 , H04W88/02
Abstract: Methods, systems, and computer readable media for stress testing mobile network equipment using CPRI are disclosed. According to one method, a plurality of messages is generated for simulating a plurality of user equipment (UE) devices. The plurality of messages is transmitted over a common public radio interface (CPRI) link to a radio equipment controller (REC) in order to stress test the REC component.
Abstract translation: 公开了使用CPRI进行应力测试移动网络设备的方法，系统和计算机可读介质。 根据一种方法，生成用于模拟多个用户设备（UE）设备的多个消息。 多个消息通过公共无线电接口（CPRI）链路发送到无线电设备控制器（REC），以便对REC组件进行压力测试。
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Patent Agency Ranking
14.发明申请METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR STRESS TESTING MOBILE NETWORK EQUIPMENT USING A COMMON PUBLIC RADIO INTERFACE (CPRI) 有权方法，系统和计算机可读介质，用于应用测试移动网络设备使用普通无线电接口（CPRI）公开(公告)号：US20100075678A1
公开(公告)日：2010-03-25
申请号：US12337285
申请日：2008-12-17
Applicant: Arda Akman , Matthew Balkwill , David Hammond , Richard Karp , Edward Panofsky , Glenn Stewart , Kalyan Sundhar
Inventor： Arda Akman , Matthew Balkwill , David Hammond , Richard Karp , Edward Panofsky , Glenn Stewart , Kalyan Sundhar
CPC classification number: H04W24/06 , H04L41/145 , H04L43/50 , H04W88/02
Abstract: Methods, systems, and computer readable media for stress testing mobile network equipment using CPRI are disclosed. According to one method, a plurality of messages is generated for simulating a plurality of user equipment (UE) devices. The plurality of messages is transmitted over a common public radio interface (CPRI) link to a radio equipment controller (REC) in order to stress test the REC component.
Abstract translation: 公开了使用CPRI进行应力测试移动网络设备的方法，系统和计算机可读介质。 根据一种方法，生成用于模拟多个用户设备（UE）设备的多个消息。 多个消息通过公共无线电接口（CPRI）链路发送到无线电设备控制器（REC），以便对REC组件进行压力测试。
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公开(公告)号：US07374900B2
公开(公告)日：2008-05-20
申请号：US10553650
申请日：2004-03-16
Applicant: Serguei Soukharev , David Hammond
Inventor： Serguei Soukharev , David Hammond
CPC classification number: C07F9/65522 , C07F9/6561 , C12Q1/42
Abstract: Disclosed are compounds of the formula (I): wherein R3, R4, R5, R9, and R10 are selected from the group consisting of H and groups or atoms other than H, and R6 and R8 are halo or hydrogen; X1, X2, and X3 are independently O or S; provided that R9 and R10 are not simultaneously H, when all of X1, X2, and X3 are O; and of the formula (II) wherein R11-R14 are selected from the group consisting of H and groups or atoms other than H; X4-X9 are independently O or S; n and m are 0 or 1 but m and n cannot be 0 simultaneously; R15-R24 can be H or any substituent so long as the compound of formula II upon hydrolysis provides a fluorescent compound. These compounds are useful as substrates with high specificity for organophosphatase particularly human paraoxonase and bacterial organophosphorus hydrolase. Also disclosed is a method for detecting and/or measuring the paraoxonase activity in a fluid comprising contacting the fluid with a fluorescent substrate and measuring the fluorescence of the fluorescent product formed.
Abstract translation: 公开了式（I）的化合物：其中R 3，R 4，R 5，R 9， 和R 10选自H和H以外的基团或原子，R 6和R 8是卤素或 氢; X 1，X 2，X 3和X 3独立地为O或S; 条件是当R 9和R 10均为H时，当X 1，X 2和X 2都全部时，R 9和R 10不同时为H， X 3是O; 和其中R 11 -R 14的式（II）选自H和H以外的基团或原子; X S 9 独立地是O或S; n和m是0或1，但m和n不能同时为0; 只要水解的式II化合物提供荧光化合物，R 15 -R 24可以是H或任何取代基。 这些化合物可用作对有机磷酸酶特别是人类对氧磷酶和细菌有机磷水解酶具有高特异性的底物。 还公开了一种用于检测和/或测量流体中对氧磷酶活性的方法，包括使流体与荧光底物接触并测量形成的荧光产物的荧光。
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公开(公告)号：US20070015230A1
公开(公告)日：2007-01-18
申请号：US11454801
申请日：2006-06-19
Applicant: David Hammond , Julia Lathrop
Inventor： David Hammond , Julia Lathrop
CPC classification number: C07K1/047 , G01N33/543 , G01N33/6803 , G01N33/6845
Abstract: The invention provides a method of identifying and detecting targets in blood samples by binding to multiple ligands. The method comprises providing ligands attached to a support, and contacting the ligands with targets in blood to allow at least one target to bind to at least one ligand. The method further comprises removal of non-bound targets and cellular components such as blood cells, platelets, abundant plasma proteins followed by dissociation and elution of the target(s). The eluted targets are detected by a variety of means in concentrations which are a function of their presence in one sample as compared with their concentration in a second sample and are simultaneously enriched for trace components.
Abstract translation: 本发明提供了通过结合多个配体鉴定和检测血液样品中的靶标的方法。 该方法包括提供与支持物连接的配体，并使配体与血液中的靶标接触，以使至少一种靶标与至少一种配体结合。 该方法还包括除去未结合的靶和细胞组分，例如血细胞，血小板，丰富的血浆蛋白，随后解离和洗脱靶标。 洗脱的目标通过各种方式检测，其浓度是它们在一个样品中的存在与其在第二个样品中的浓度相比的函数，并且同时富集痕量组分。
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公开(公告)号：US20060275829A1
公开(公告)日：2006-12-07
申请号：US11454800
申请日：2006-06-19
Applicant: David Hammond , Julia Lathrop
Inventor： David Hammond , Julia Lathrop
CPC classification number: C07K1/047 , C07K1/1072 , G01N33/543 , G01N33/54353 , G01N33/6803 , G01N33/6842 , G01N33/6845
Abstract: The present invention relates to solid-phase combinatorial peptide libraries synthesized on chromatography beads and their use to prepare samples for proteomic investigations.
Abstract translation: 本发明涉及在色谱珠上合成的固相组合肽文库及其用于制备蛋白质组学调查样品的用途。
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公开(公告)号：US20060275753A1
公开(公告)日：2006-12-07
申请号：US11454799
申请日：2006-06-19
Applicant: David Hammond , Julia Lathrop
Inventor： David Hammond , Julia Lathrop
CPC classification number: C07K1/047 , G01N33/543 , G01N33/6803 , G01N33/6845 , G01N2500/00
Abstract: The invention provides a method of binding multiple targets in samples by binding to multiple ligands. The method comprises providing ligands attached to a support, and contacting the ligands with targets to produce at least two target-ligand-support complexes. The method further comprises removal of non-bound targets followed by elution of the bound targets. The eluted targets are present in concentrations of a particular analyte that is a function of their comparative concentrations in different samples. Furthermore, the mixture is enriched for trace components.
Abstract translation: 本发明提供了通过结合多个配体结合样品中多个靶标的方法。 该方法包括提供连接到载体的配体，并使配体与靶标接触以产生至少两种靶 - 配体 - 支持复合物。 该方法还包括除去未结合的靶物，然后洗脱结合的靶标。 洗脱的目标以特定分析物的浓度存在，其是不同样品中其比较浓度的函数。 此外，混合物富集痕量组分。
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