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    PURIFICATION OF IMMUNOGLOBULINS USING AFFINITY CHROMATOGRAPHY AND PEPTIDE LIGANDS
    3.
    发明申请
    PURIFICATION OF IMMUNOGLOBULINS USING AFFINITY CHROMATOGRAPHY AND PEPTIDE LIGANDS 审中-公开
    使用亲和色谱和肽配体进行免疫球蛋白的纯化

    公开(公告)号：US20140243210A1

    公开(公告)日：2014-08-28

    申请号：US13462373

    申请日：2012-05-02

    申请人： Ruben Carbonell ,  Haiou Yang ,  Patrick Gurgel

    发明人： Ruben Carbonell ,  Haiou Yang ,  Patrick Gurgel

    IPC分类号： C07K1/22 ,  G01N33/68

    CPC分类号： C07K1/22 ,  B01D15/3809 ,  B01J20/286 ,  C07K7/06 ,  G01N33/6854

    摘要： An immunoglobulin binding peptide having the general formula, from amino terminus to carboxy terminus, of Z—R1—R2—R3—R4—R5—R6—X, is described, wherein: R1 is H or Y; R2 is a hydrophobic, preferentially aromatic, amino acid (for example W, F, Y, V); R3 is a positively charged or aromatic amino acid (for example R, H, F, W); R4 is a hydrophobic or positively charged amino acid (for example G, Y, R, K, L); R5 is a positively charged or aromatic amino acid (for example W, F, R, H, Y); R6 a random amino acid but preferably hydrophobic or negatively charged (for example V, W, L, D, H); X is present or absent and when present is a linking group; and Z is present or absent and when present is a capping group bonded to the N terminus of R1; and wherein the amino acids of said peptide are in D form, L form, or a combination thereof. Methods of using such peptides for the purification of Immunoglobulins are also described

    摘要翻译： 描述了Z-R1-R2-R3-R4-R5-R6-X的通式为氨基末端至羧基末端的免疫球蛋白结合肽，其中：R1为H或Y; R2是疏水的，优选芳族的氨基酸（例如W，F，Y，V）; R3是带正电荷或芳族氨基酸（例如R，H，F，W）; R4是疏水或带正电荷的氨基酸（例如G，Y，R，K，L）; R5是带正电或芳族氨基酸（例如W，F，R，H，Y）; R6是随机氨基酸，但优选疏水或带负电荷（例如V，W，L，D，H）; X存在或不存在，并且当存在时为连接基团; 并且Z存在或不存在，并且当存在时是与R 1的N末端键合的封端基团; 并且其中所述肽的氨基酸为D型，L型或其组合。 还描述了使用这些肽来纯化免疫球蛋白的方法

    Hydrogenation of Polymers in the Presence of Supercritical Carbon Dioxide
    5.
    发明申请
    Hydrogenation of Polymers in the Presence of Supercritical Carbon Dioxide 失效
    聚合物在超临界二氧化碳存在下的氢化作用

    公开(公告)号：US20070270554A1

    公开(公告)日：2007-11-22

    申请号：US10533625

    申请日：2003-11-03

    申请人： George Roberts ,  Dawei Xu ,  Douglas Kiserow ,  Ruben Carbonell

    发明人： George Roberts ,  Dawei Xu ,  Douglas Kiserow ,  Ruben Carbonell

    IPC分类号： C08F8/00 ,  C08C19/00

    CPC分类号： C08F8/04 ,  Y02P20/544

    摘要： A method of hydrogenating a polymer comprises: (a) providing a dense phase, the dense phase comprising a polymer in a solvent; (b) providing a catalyst system, the catalyst system comprising as least one metal hydrogenation catalyst (preferably including nickel or ruthenium); and (c) providing a light phase, the light phase comprising, consisting of or consisting essentially of hydrogen and carbon dioxide; and (d) contacting the dense phase, the light phase and the catalyst system under conditions in which the hydrogen reacts with the polymer and hydrogenates the polymer.

    摘要翻译： 氢化聚合物的方法包括：（a）提供致密相，所述致密相在溶剂中包含聚合物; （b）提供催化剂体系，所述催化剂体系包含至少一种金属氢化催化剂（优选包括镍或钌）; 和（c）提供轻相，所述轻相包含由氢和二氧化碳组成或基本上由氢和二氧化碳组成; 和（d）在氢与聚合物反应并氢化聚合物的条件下使密相，轻相和催化剂体系接触。

    Purification of immunoglobulins using affinity chromatography and peptide ligands
    7.
    发明申请
    Purification of immunoglobulins using affinity chromatography and peptide ligands 有权
    使用亲和层析和肽配体纯化免疫球蛋白

    公开(公告)号：US20060153834A1

    公开(公告)日：2006-07-13

    申请号：US11035016

    申请日：2005-01-13

    申请人： Ruben Carbonell ,  Haiou Yang ,  Guangquan Wang ,  Patrick Gurgel

    发明人： Ruben Carbonell ,  Haiou Yang ,  Guangquan Wang ,  Patrick Gurgel

    IPC分类号： G01N33/53 ,  A61K39/395 ,  C07K7/06 ,  C40B40/10

    CPC分类号： C07K1/22 ,  B01D15/3809 ,  B01J20/286 ,  C07K7/06 ,  G01N33/6854

    摘要： An immunoglobulin binding peptide having the general formula, from amino terminus to carboxy terminus, of Z-R1—R2—R3—R4—R5—R6—X, is described, wherein: R1 is H or Y; R2 is a hydrophobic, preferentially aromatic, amino acid (for example W, F, Y, V); R3 is a positively charged or aromatic amino acid (for example R, H, F, W); R4 is a hydrophobic or positively charged amino acid (for example G, Y, R, K, L); R5 is a positively charged or aromatic amino acid (for example W, F, R, H, Y); R6 a random amino acid but preferably hydrophobic or negatively charged (for example V, W, L, D, H); X is present or absent and when present is a linking group; and Z is present or absent and when present is a capping group bonded to the N terminus of R1; and wherein the amino acids of said peptide are in D form, L form, or a combination thereof. Methods of using such peptides for the purification of Immunoglobulins are also described

    摘要翻译： 具有通式从氨基末端至羧基末端的免疫球蛋白结合肽，ZR R 2 -R 3→3-SUP 其中：R 1是H或Y;其中R 1，R 2，R 3，R 4，R 4，R 4， R 2是疏水性，优选芳族的氨基酸（例如W，F，Y，V）; R 3是带正电或芳族氨基酸（例如R，H，F，W）; R 4是疏水或带正电荷的氨基酸（例如G，Y，R，K，L）; R 5是带正电荷或芳族氨基酸（例如W，F，R，H，Y）; R 6为无规氨基酸，但优选疏水或带负电荷（例如V，W，L，D，H）; X存在或不存在，并且当存在时为连接基团; 并且Z存在或不存在，并且当存在时是与R 1的N末端键合的封端基团; 并且其中所述肽的氨基酸为D型，L型或其组合。 还描述了使用这些肽来纯化免疫球蛋白的方法

    Prion protein binding materials and methods of use
    8.
    发明申请
    Prion protein binding materials and methods of use 有权
    朊病毒蛋白结合材料及使用方法

    公开(公告)号：US20050014196A1

    公开(公告)日：2005-01-20

    申请号：US10817117

    申请日：2004-04-02

    申请人： Ruben Carbonell ,  Honglue Shen ,  Patrick Gurgel ,  Viterose Wiltshire-Lyerly ,  David Hammond ,  Steven Burton

    发明人： Ruben Carbonell ,  Honglue Shen ,  Patrick Gurgel ,  Viterose Wiltshire-Lyerly ,  David Hammond ,  Steven Burton

    IPC分类号： C12N20060101 ,  G01N33/53 ,  G01N33/68

    CPC分类号： G01N33/6896

    摘要： Prion protein binding materials and methods for using the binding materials to detect or remove a prion protein from a sample, such as a biological fluid or an environmental sample. The binding materials are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), recombinant prion protein (PrPr), and proteinase resistant prion protein (PrPres). Prions from various species, including humans and hamsters, are bound by the binding materials.

    摘要翻译： 朊病毒蛋白结合材料和使用结合材料从样品如生物流体或环境样品中检测或除去朊病毒蛋白的方法。 结合材料能够结合一种或多种形式的朊病毒蛋白，包括细胞朊蛋白（PrPc），感染性朊病毒蛋白（PrPsc），重组朊病毒蛋白（PrPr）和蛋白酶抗性朊病毒蛋白（PrPres）。 来自各种物种的朊病毒，包括人类和仓鼠，都受到结合物质的束缚。

    PURIFICATION OF IMMUNOGLOBULINS USING AFFINITY CHROMATOGRAPHY AND PEPTIDE LIGANDS
    9.
    发明申请
    PURIFICATION OF IMMUNOGLOBULINS USING AFFINITY CHROMATOGRAPHY AND PEPTIDE LIGANDS 审中-公开
    使用亲和色谱和肽配体进行免疫球蛋白的纯化

    公开(公告)号：US20090005261A1

    公开(公告)日：2009-01-01

    申请号：US12178004

    申请日：2008-07-23

    申请人： Ruben Carbonell ,  Haiou Yang ,  Guangquan Wang ,  Patrick Gurgel

    发明人： Ruben Carbonell ,  Haiou Yang ,  Guangquan Wang ,  Patrick Gurgel

    IPC分类号： C40B30/04 ,  C07K16/00 ,  G01N33/544 ,  G01N33/545 ,  G01N33/53

    CPC分类号： C07K1/22 ,  B01D15/3809 ,  B01J20/286 ,  C07K7/06 ,  G01N33/6854

    摘要： An immunoglobulin binding peptide having the general formula, from amino terminus to carboxy terminus, of Z-R1—R2—R3—R4—R5—R6—X, is described, wherein: R1 is H or Y; R2 is a hydrophobic, preferentially aromatic, amino acid (for example W, F, Y, V); R3 is a positively charged or aromatic amino acid (for example R, H, F, W); R4 is a hydrophobic or positively charged amino acid (for example G, Y, R, K, L); R5 is a positively charged or aromatic amino acid (for example W, F, R, H, Y); R6 a random amino acid but preferably hydrophobic or negatively charged (for example V, W, L, D, H); X is present or absent and when present is a linking group; and Z is present or absent and when present is a capping group bonded to the N terminus of R1; and wherein the amino acids of said peptide are in D form, L form, or a combination thereof. Methods of using such peptides for the purification of Immunoglobulins are also described

    摘要翻译： 描述了Z-R1-R2-R3-R4-R5-R6-X的通式为氨基末端至羧基末端的免疫球蛋白结合肽，其中：R1为H或Y; R2是疏水的，优选芳族的氨基酸（例如W，F，Y，V）; R3是带正电荷或芳族氨基酸（例如R，H，F，W）; R4是疏水或带正电荷的氨基酸（例如G，Y，R，K，L）; R5是带正电或芳族氨基酸（例如W，F，R，H，Y）; R6是随机氨基酸，但优选疏水或带负电荷（例如V，W，L，D，H）; X存在或不存在，并且当存在时为连接基团; 并且Z存在或不存在，并且当存在时是与R 1的N末端键合的封端基团; 并且其中所述肽的氨基酸为D型，L型或其组合。 还描述了使用这些肽来纯化免疫球蛋白的方法

    Purification of immunoglobulins using affinity chromatography and peptide ligands
    10.
    发明授权
    Purification of immunoglobulins using affinity chromatography and peptide ligands 有权
    使用亲和层析和肽配体纯化免疫球蛋白

    公开(公告)号：US07408030B2

    公开(公告)日：2008-08-05

    申请号：US11035016

    申请日：2005-01-13

    申请人： Ruben Carbonell ,  Haiou Yang ,  Patrick Gurgel

    发明人： Ruben Carbonell ,  Haiou Yang ,  Patrick Gurgel

    IPC分类号： C07K7/06 ,  C07K1/22

    CPC分类号： C07K1/22 ,  B01D15/3809 ,  B01J20/286 ,  C07K7/06 ,  G01N33/6854

    摘要： An immunoglobulin binding peptide having the general formula, from amino terminus to carboxy terminus, of Z-R1—R2—R3—R4—R5—R6—X, is described, wherein: R1 is H or Y; R2 is a hydrophobic, preferentially aromatic, amino acid (for example W, F, Y, V); R3 is a positively charged or aromatic amino acid (for example R, H, F, W); R4 is a hydrophobic or positively charged amino acid (for example G, Y, R, K, L); R5 is a positively charged or aromatic amino acid (for example W, F, R, H, Y); R6 a random amino acid but preferably hydrophobic or negatively charged (for example V, W, L, D, H); X is present or absent and when present is a linking group; and Z is present or absent and when present is a capping group bonded to the N terminus of R1; and wherein the amino acids of said peptide are in D form, L form, or a combination thereof. Methods of using such peptides for the purification of Immunoglobulins are also described.

    摘要翻译： 具有通式从氨基末端至羧基末端的免疫球蛋白结合肽，ZR R 2 -R 3→3-SUP 其中：R 1是H或Y;其中R 1，R 2，R 3，R 4，R 4，R 4， R 2是疏水性，优选芳族的氨基酸（例如W，F，Y，V）; R 3是带正电或芳族氨基酸（例如R，H，F，W）; R 4是疏水或带正电荷的氨基酸（例如G，Y，R，K，L）; R 5是带正电荷或芳族氨基酸（例如W，F，R，H，Y）; R 6为无规氨基酸，但优选疏水或带负电荷（例如V，W，L，D，H）; X存在或不存在，并且当存在时为连接基团; 并且Z存在或不存在，并且当存在时是与R 1的N末端键合的封端基团; 并且其中所述肽的氨基酸为D型，L型或其组合。 还描述了使用这些肽来纯化免疫球蛋白的方法。