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    Orthopedic screw for use in repairing small bones
    14.
    发明申请
    Orthopedic screw for use in repairing small bones 审中-公开
    用于修复小骨的矫形螺钉

    公开(公告)号：US20060173462A1

    公开(公告)日：2006-08-03

    申请号：US11340365

    申请日：2006-01-26

    Applicant: David Kay ,  Lee Strnad ,  Dustin Ducharme

    Inventor： David Kay ,  Lee Strnad ,  Dustin Ducharme

    IPC: A61B17/58

    CPC classification number: A61B17/8635 ,  A61B17/8605 ,  A61B17/863 ,  A61B2017/00004

    Abstract: The present invention relates to an orthopedic screw having a torque driving head with spherical surface for multiaxial use, a self starting, self tapping insertion tip and a threaded portion including a modified cancellous thread. The threaded portion has a major diameter defined by a spiraling thread and a minor diameter. The head is joined to the threaded portion by an area of from about 2 to about 6 turns of the thread along the longitudinal axis in which the minor diameter tapers by an angle of from about 4 to about 12° and the major diameter of the screw remaining substantially the same meaning that the major diameter is constant to about +/−0.05 mm along the length of the threaded portion. The screw includes a multilobe torque driving recess joined to a cylindrical recess that corresponds to a cylindrical post on the torque driver so as to form a press fit which acts to self-center the screw, to help avoid stripping of the screw/driver interface and to hold the screw in place on the torque driver prior to implantation. In a further embodiment, the screw includes a variable pitch portion for about half of the length starting from the distil end. The screw can be used be itself, or with a plate. Further a new method of using the screw with a plate is presented in which the screw extends through a cortical section of bone into a cancellous portion but not through the adjacent cortical.

    Abstract translation: 本发明涉及具有用于多轴使用的具有球面的扭矩驱动头的自动螺丝，自启动，自攻丝插入尖端和包括修改的松质线的螺纹部分。 螺纹部分具有由螺旋螺纹和较小直径限定的大直径。 头部沿着纵向轴线连接到螺纹部分约2至约6圈的螺纹区域，其中小直径锥度约4至约12度的角度和螺杆的大直径 保持与螺纹部分的长度大致相同的意思，即长径大约为+/- 0.05mm。 所述螺杆包括多个转矩驱动凹部，所述多叶扭矩驱动凹部接合到对应于所述扭矩驱动器上的圆柱形柱的圆柱形凹部，以便形成用于使所述螺钉自对中心的压配合，以有助于避免螺钉/驱动器接口的剥离， 在植入前将螺丝固定在扭矩驱动器上。 在另一实施例中，螺杆包括从蒸馏端开始的大约一半长度的可变节距部分。 螺钉可以自己使用，也可以用于板材。 还提出了使用具有板的螺钉的新方法，其中螺钉通过骨的皮质部分延伸进入松质部分而不通过相邻的皮层。

    Carbamate caspase inhibitors and uses thereof
    17.
    发明授权
    Carbamate caspase inhibitors and uses thereof 失效
    氨基甲酸酯半胱天冬酶抑制剂及其用途

    公开(公告)号：US06689784B2

    公开(公告)日：2004-02-10

    申请号：US09821161

    申请日：2001-03-29

    Applicant: David Bebbington ,  Ronald Knegtel ,  Michael Mortimore ,  David Kay ,  Julian M. C. Golec

    Inventor： David Bebbington ,  Ronald Knegtel ,  Michael Mortimore ,  David Kay ,  Julian M. C. Golec

    IPC: C07D20982

    CPC classification number: C07D403/12 ,  C07D209/08 ,  C07D209/86 ,  C07D221/12 ,  C07D223/26 ,  C07D223/28 ,  C07D279/30

    Abstract: This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; Y is an electronegative leaving group; R2 is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R3 is a group capable of fitting into the S2 subsite of a caspase enzyme; R4 and R5 are taken together with the intervening nitrogen to form heterocyclic ring and R is as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1&bgr; secretion.

    Abstract translation: 本发明提供了式I的半胱天冬酶抑制剂：其中Z是氧或硫; R 1是氢，-CHN 2，R 1，CH 2 OR，CH 2 SR或-CH 2 Y; Y是电负离子团; R 2是CO 2 H，CH 2 CO 2 H或其酯，酰胺或等体积体; R 3是能够适应半胱天冬酶的S2亚位点的基团; R 4和R 5与中间的氮一起形成杂环，R如说明书中所述。 这些化合物是凋亡和IL-1β分泌的有效抑制剂。

    Hybrid refractive/diffractive achromatic lens for optical data storage systems
    19.
    发明授权
    Hybrid refractive/diffractive achromatic lens for optical data storage systems 失效
    用于光学数据存储系统的混合折射/衍射消色差透镜

    公开(公告)号：US5349471A

    公开(公告)日：1994-09-20

    申请号：US17712

    申请日：1993-02-16

    Applicant: G. Michael Morris ,  David Kay ,  Dale Buralli ,  David Kubalak

    Inventor： G. Michael Morris ,  David Kay ,  Dale Buralli ,  David Kubalak

    IPC: G02B5/18 ,  G02B27/00 ,  G11B7/135 ,  G02B3/08 ,  G02B27/44

    CPC classification number: G02B5/1895 ,  G02B27/0037 ,  G02B27/4238 ,  G02B5/1876 ,  G11B7/1374 ,  G11B2007/13722

    Abstract: A diffractive/refractive hybrid lens for use in an optical data storage system as an objective is provided by a convex-plano singlet having a refractive element defined by plano-convex surfaces and a diffractive element defined by a Fresnel zone-like pattern on the plano surface which together provide the total power of the lens. The refractive lens is made of a high index, high dispersion glass so that the curvature and thickness of the refractive lens is minimized while providing a large numerical aperture (at least 0.45) at the expense of increased longitudinal chromatic aberration, which are compensated by the diffractive element and without the need for one or more additional curved surfaces as in low index biaspheric glass objective lenses for chromatic and mono-chromatic aberration reduction, which increases the thickness and curvatures of the lens. The invention enables longitudinal chromatic aberration to be corrected for at least a 10 nm band width around a center wavelength over a 20 nm range, as results when different lasers are used and as laser power varies during optical data storage on an optical data storage device (an optical disk). The thin, light weight low curvature achromat has maximum tolerance for various possible manufacturing errors such as decentering, variations in thickness of the lens, tilt and focal length especially for on-axis field of view less than 2.degree. while providing a very high quality spot (Strehl ratio of at least 0.9.).

    Abstract translation: 用作光学数据存储系统作为目的的衍射/折射混合透镜由具有由平凸表面限定的折射元件和由平面上的菲涅耳带状图案限定的衍射元件的凸平面单重晶片提供 一起提供透镜的总功率的表面。 折射透镜由高折射率高分散玻璃制成，使得折射透镜的曲率和厚度最小化，同时以增加的纵向色差为代价提供大的数值孔径（至少为0.45），其由 并且不需要一个或多个附加的弯曲表面，如在用于彩色和单色像差降低的低折射率偏置玻璃物镜中，这增加了透镜的厚度和曲率。 本发明使得能够在20nm范围内围绕中心波长的至少10nm带宽校正纵向色差，这是因为当使用不同的激光器并且在​​光学数据存储装置中的光学数据存储期间激光功率变化时的结果 光盘）。 薄的，重量轻的低曲率消色差对于各种可能的制造误差具有最大公差，例如偏心，透镜厚度变化，倾斜和焦距，特别是对于小于2°的轴上视场，同时提供非常高的质量点 （Strehl比至少为0.9）。

    Housing for animal feedstuff
    20.
    发明授权
    Housing for animal feedstuff 有权
    动物饲料住房

    公开(公告)号：US08919287B2

    公开(公告)日：2014-12-30

    申请号：US12972784

    申请日：2010-12-20

    Applicant: Stephen Aisthorpe ,  David Kay

    Inventor： Stephen Aisthorpe ,  David Kay

    IPC: A01K1/00 ,  A01K5/00 ,  A01K5/01

    CPC classification number: A01K5/01 ,  A01K5/0107

    Abstract: A housing for animal feedstuff including a base, a roof extending over the base, uprights spaced apart from one another and extending between the base and the roof, and a container locatable between the uprights for containing feedstuff. Livestock, such as cattle, access feedstuff within the container by way of spaces between the uprights. In an embodiment, the uprights are telescopic and the roof can be pivoted between raised and lowered positions relative to the uprights.

    Abstract translation: 一种用于动物饲料的壳体，包括基部，在基部上延伸的屋顶，彼此间隔开并在基部和屋顶之间延伸的立柱以及位于用于容纳饲料的立柱之间的容器。 牲畜，如牛，通过立柱之间的空间进入容器内的饲料。 在一个实施例中，立柱是可伸缩的，并且屋顶可以相对于立柱在升高和降低的位置之间枢转。

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