公开(公告)号：US20080132991A1

公开(公告)日：2008-06-05

申请号：US11565065

申请日：2006-11-30

申请人： Leonard Pinchuk ,  Yasushi Pedro Kato ,  Marc Ramer

发明人： Leonard Pinchuk ,  Yasushi Pedro Kato ,  Marc Ramer

IPC分类号： A61F2/82 ,  B05D7/00 ,  B05D3/10

CPC分类号： C08B37/006 ,  A61F2/06 ,  A61F2/07 ,  A61F2/82 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2420/02 ,  C09D105/00 ,  C08L5/00

摘要： A method for producing ionically cross-linked gellan gum includes dissolving the material in a first liquid solution that includes a dissolving liquid. The first liquid solution is applied to a workpiece to form a polysaccharide-based coating on the workpiece. The coating is dried to remove a substantial portion of the dissolving liquid. Subsequent to drying, the coating is exposed to a second liquid solution that includes a compound that promotes ionic cross-linking of the coating. In the preferred embodiment, the dissolving liquid comprises water and possibly a polar solvent. The ionic cross-linking compound preferably comprises a divalent cation such as calcium (Ca2+), or possibly strontium (Sr2+), magnesium (Mg2+), barium (Ba2+), or other multivalent ions. Such a method forms a uniform ionically cross-linked film and/or coating for diverse applications, including medical devices such as implantable vascular grafts, stent-grafts and/or stents.

摘要翻译： 用于生产离子交联的结冷胶的方法包括将该材料溶解在包括溶解液的第一液体溶液中。 将第一液体溶液施加到工件上以在工件上形成多糖基涂层。 将涂层干燥以除去大部分溶解液。 在干燥之后，将涂层暴露于包括促进涂层的离子交联的化合物的第二液体溶液中。 在优选的实施方案中，溶解液体包含水和可能的极性溶剂。 离子交联化合物优选包含二价阳离子如钙（Ca 2+），或可能的锶（Sr 2+），镁（Mg 2+） +），钡（Ba 2+）或其它多价离子。 这种方法形成用于各种应用的均匀的离子交联膜和/或涂层，包括诸如可植入血管移植物，支架移植物和/或支架的医疗装置。

公开(公告)号：US06656215B1

公开(公告)日：2003-12-02

申请号：US09714080

申请日：2000-11-16

申请人： Andrew Yanez ,  Frank Butaric ,  Marc Ramer

发明人： Andrew Yanez ,  Frank Butaric ,  Marc Ramer

IPC分类号： A61F206

CPC分类号： A61F2/88 ,  A61B17/064 ,  A61B17/0682 ,  A61F2/064 ,  A61F2/07 ,  A61F2/848 ,  A61F2/91 ,  A61F2/915 ,  A61F2/95 ,  A61F2/954 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/075 ,  A61F2002/825 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0008 ,  A61F2230/001 ,  A61F2230/0013 ,  A61F2230/005 ,  A61F2250/006

摘要： A stent-graft for insertion into a body lumen, such as a blood vessel, is utilized in order to repair such lumen. The stent-graft includes a substantially cylindrical hollow expandable stent comprising a plurality of interconnected struts. The stent has a distal end and a proximal end, and an interior surface and an exterior surface. At least one strut of the stent has first and second apertures extending therethrough from the interior surface to the exterior surface. The stent-graft also includes a graft member covering a predetermined portion of least one of the interior surface and the exterior surface of the stent. In addition, the stent-graft further includes a staple for attaching the graft member to the stent. The staple has a crown and two legs extending therefrom. At least one of the legs of the staple extends through the graft material and through the first aperture. Both of the legs are bent inwardly towards said crown such that they evert back and extend through the second aperture.

摘要翻译： 为了修复这样的内腔，使用用于插入诸如血管的体腔的支架移植物。 支架移植物包括基本上圆柱形的中空可扩张支架，其包括多个互连的支柱。 支架具有远端和近端，以及内表面和外表面。 支架的至少一个支柱具有从内表面延伸到外表面的第一和第二孔。 支架移植物还包括覆盖支架的内表面和外表面中的至少一个的预定部分的移植部件。 此外，支架移植物还包括用于将移植物件附接到支架的钉。 订书钉具有从其延伸的表冠和两条腿。 订书钉的至少一条腿延伸穿过移植材料并穿过第一孔。 两个腿部朝向所述冠部向内弯曲，使得它们回退并延伸穿过第二孔。