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    Implantable drug delivery system with piston acutation
    11.
    发明授权
    Implantable drug delivery system with piston acutation 失效
    具有活塞功能的可植入药物递送系统

    公开(公告)号：US5196002A

    公开(公告)日：1993-03-23

    申请号：US716926

    申请日：1991-06-18

    申请人： Barry K. Hanover ,  Stephen C. Jacobsen ,  Eric M. Simon ,  Tomasz Petelenz ,  Michael G. Mladejovsky

    发明人： Barry K. Hanover ,  Stephen C. Jacobsen ,  Eric M. Simon ,  Tomasz Petelenz ,  Michael G. Mladejovsky

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61M31/00

    CPC分类号： A61K9/0024 ,  A61M31/002

    摘要： An implantable drug delivery system includes a housing having a base end and a discharge end, for holding drug solution at the discharge end, a valve disposed at the discharge end to allow a drug solution to flow from inside the housing, through the valve and out of the housing when solution pressure is applied to the valve, a piston slidably disposed in the housing to slide between the base end and discharge end to force solution toward the discharge end and out the valve, and a spring disposed in the housing between the piston and the base end thereof for urging the piston toward the discharge end. A plurality of different length tethers are connected at one end to the piston and at the other end to a respective release node located at the base end of the housing. Each release node holds the other end of a respective one of the tethers until a release signal is received at which time it releases the tether. A timing circuit is disposed in the housing at the base end to supply release signals sequentially to the nodes in order of the shortest tether node to the longest tether node so that as a tether is released, the piston is allowed to move toward the discharge end of the housing to thereby discharge or bolus of drug solution from the housing, until the next shortest unreleased tether stops further movement of the piston.

    摘要翻译： 可植入药物输送系统包括具有基端和排出端的壳体，用于在排出端保持药物溶液，设置在排出端处的阀，以允许药物溶液从壳体内部流过阀门并出口 的壳体，其中所述壳体被施加到所述阀上;活塞，其可滑动地设置在所述壳体中以在所述基端和排出端之间滑动，以迫使溶液朝向排出端并排出所述阀;以及弹簧，设置在所述壳体中的所述活塞 和其基端用于将活塞推向排出端。 多个不同长度的系绳在一端连接到活塞，另一端连接到位于壳体基端的相应的释放节点。 每个释放节点保持系链中相应一个的另一端，直到接收释放信号，此时它释放系绳。 定时电路设置在基座的外壳中，以便按照最短系链节点到最长系绳节点的顺序向节点顺序地提供释放信号，以便当释放系绳时，允许活塞向排放端移动 从而将药物溶液从壳体排出或推出，直到下一个最短的未释放的系链停止活塞的进一步移动。

    Detachable clasping fastener
    14.
    发明授权
    Detachable clasping fastener 失效
    可拆卸扣紧紧固件

    公开(公告)号：US06243922B1

    公开(公告)日：2001-06-12

    申请号：US09518599

    申请日：2000-03-03

    申请人： Eric M. Simon

    发明人： Eric M. Simon

    IPC分类号： A44B1300

    CPC分类号： A44B15/00 ,  F16B45/06 ,  Y10T24/1379 ,  Y10T24/45298

    摘要： A reversibly attachable fastener has a generally figure-8 geometry when in the engaged state. The fastener is composed of two generally symmetric halves, each comprising arm portions, shoulder portions, and head portions, and the halves are connected by a spring loop. One half of the fastener contains a window feature that allows the opposing, singular half to extend through and be supported in a nested fashion. The half containing the window feature has crown protrusions on the head portions which are then spanned by a bridge structure. The opposing, singular half is provided with a crown protrusion which is notched, this crown protrusion catching on the bridge structure to maintain the fastener in the engaged state. The fastener can be used to easily and reversibly attach various objects, such as keys to keyrings or identification tags to luggage.

    摘要翻译： 当处于接合状态时，可逆连接的紧固件具有大致图8的几何形状。 紧固件由两个大致对称的半部组成，每个半部包括臂部，肩部和头部，并且两半通过弹簧环连接。 紧固件的一半包含窗口特征，其允许相对的单个一半延伸穿过并以嵌套的方式支撑。 包含窗户特征的一半在头部上具有冠状突起，然后由桥结构跨越。 相对的单个半部设置有凹口的凸起突起，该凸起突起卡在桥结构上以将紧固件保持在接合状态。 紧固件可用于容易且可逆地附接各种物体，例如键盘的钥匙或识别标签到行李箱。

    Cell culture apparatus and associated methods
    15.
    发明授权
    Cell culture apparatus and associated methods 有权
    细胞培养装置及相关方法

    公开(公告)号：US08486692B2

    公开(公告)日：2013-07-16

    申请号：US12514798

    申请日：2007-11-14

    申请人： Eric M. Simon

    发明人： Eric M. Simon

    IPC分类号： C12M1/24 ,  C12M1/18 ,  C12N5/02 ,  B01L3/00 ,  B28B23/00

    CPC分类号： C12M23/20 ,  C12M23/08 ,  C12M23/12 ,  C12M23/24

    摘要： A cell culture apparatus consists of a vessel or array of vessels, each comprising a substantially flat bottom and substantially vertical sides, and composed of a substantially gas permeable material. The inner bottom surface of the vessel is commonly textured to provide the cells with adequate features for attachment and spreading. The vessel may include an integral annular flange which can be used to suspend the vessel from a suspensory element of a rack structure. To promote cell attachment and growth, the inner surfaces of the vessel bottom and sides may be coated with commonly available bio-active materials. Cells cultured in the system commonly grow in three dimensions for extended periods of time, and often produce significantly higher quantities of cellular products than cells grown in conventional labware.

    摘要翻译： 细胞培养装置由容器或容器阵列组成，每个容器包括基本上平坦的底部和基本上垂直的侧面，并且由基本上透气的材料构成。 容器的内底表面通常是纹理化的，为细胞提供足够的附着和扩散特征。 容器可以包括整体的环形凸缘，其可以用于将容器悬挂在齿条结构的悬挂元件上。 为了促进细胞附着和生长，容器底部和侧面的内表面可以涂覆有常用的生物活性材料。 在系统中培养的细胞通常在三维中长时间生长，并且通常比常规实验器皿中生长的细胞产生显着更高量的细胞产物。

    Method and system for performing microabrasion and suction massage
    17.
    发明授权
    Method and system for performing microabrasion and suction massage 失效
    进行微型吸引按摩的方法和系统

    公开(公告)号：US06926681B1

    公开(公告)日：2005-08-09

    申请号：US10009932

    申请日：2000-05-11

    申请人： John S. Ramey ,  Larry K. Beardall ,  Eric M. Simon ,  Randall D. Block

    发明人： John S. Ramey ,  Larry K. Beardall ,  Eric M. Simon ,  Randall D. Block

    IPC分类号： A61H9/00 ,  A61H23/04 ,  A61B17/50

    CPC分类号： A61H9/005 ,  A61B17/54 ,  A61H2009/0014

    摘要： Massage device (10) comprising head (12), which 76 defines cavity (8) and an opening to cavity (8). Head (12) has one or more contact surfaces and post (32) connected to head (12). Post (32) is positioned within cavity (8) and extends toward the opening. Post (32) also has one or more contact surfaces. Vacuum source (49) communicating with cavity (8) provides a means for creating negative pressure with cavity (8). Additionally, a method and system for performing abrasion on a surface, such as on the skin 74 of a patient, is disclosed. The dermabrasion apparatus includes means for delivering and retrieving material to and from a selected site to be abraded, a delivery and retrieval hand piece, an abrasive handling device, and a waste retrieval holding device. Hand piece (118) is coupled to the abrasive handling device as well as the waste retrieval holding device, which is further coupled to the delivery and retrieval means.

    摘要翻译： 包括头部（12）的按摩装置（10），其中76限定空腔（8）和到空腔（8）的开口。 头部（12）具有一个或多个接触表面和连接到头部（12）的柱（32）。 柱（32）定位在腔（8）内并朝向开口延伸。 柱（32）还具有一个或多个接触表面。 与空腔（8）连通的真空源（49）提供了用腔（8）产生负压的装置。 此外，公开了一种用于在诸如患者皮肤74的表面上进行磨损的方法和系统。 磨皮设备包括用于将材料输送到所选择的现场以进行磨削的装置，输送和检索手部件，研磨处理装置和废物回收保持装置。 手工具（118）连接到研磨处理装置以及废物回收保持装置，废物回收保持装置进一步耦合到输送和检索装置。

    Disposable toothbrush cover
    19.
    发明授权
    Disposable toothbrush cover 失效
    一次性牙刷套

    公开(公告)号：US5139142A

    公开(公告)日：1992-08-18

    申请号：US625953

    申请日：1990-12-11

    申请人： Eric M. Simon

    发明人： Eric M. Simon

    IPC分类号： A46B17/04

    CPC分类号： A46B17/04 ,  A46B2200/1066

    摘要： A protective cover for the bristle portion (10) of a toothbrush (12) is adapted for disposability and reduced bulkiness. The cover is composed of two pieces of flexible, waterproof material (14, 14') which have been bonded along the top edge (16) and lateral edges (18, 20) to form a pouch-like container. The remaining lateral edges (26, 26') are supplied with rib-and-groove closure profiles (32, 34) to provide for ease of insertion and resealability. The bottom edges (22, 22') are unbonded to allow the toothbrush handle (24) to project externally. Alternately, an adhesive strip closure (72) may be used in place of rib-and-groove closure profiles (32, 34). The toothbrush cover may be produced rapidly and inexpensively to allow for disposal after a usage period of up to ten days, thereby reducing the probability of microbial colonization.

    摘要翻译： 用于牙刷（12）的刷毛部分（10）的保护盖适用于一次性并减小膨松度。 该盖由两块柔性防水材料（14,14'）组成，它们已经沿着顶部边缘（16）和侧边缘（18,20）结合以形成袋状容器。 剩余的侧边缘（26,26'）被提供有肋 - 沟槽闭合轮廓（32,34），以提供易于插入和再密封性。 底边缘（22,22'）是未粘合的，以允许牙刷手柄（24）从外部伸出。 或者，可以使用粘合剂条封闭件（72）代替肋 - 沟封闭件型材（32,34）。 可以快速且廉价地制造牙刷盖，以在使用期限长达十天后进行处置，从而降低微生物定植的可能性。