公开(公告)号：US20130274871A1

公开(公告)日：2013-10-17

申请号：US13909890

申请日：2013-06-04

Applicant: Edwards Lifesciences Corporation

Inventor： Yaacov Nitzan ,  Benjamin Spenser ,  Yaron Keidar ,  Tamir S. Levi ,  Melissa B. Denton

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61F2/2433 ,  A61F2002/9522

Abstract: A valve loading apparatus is provided for loading a crimped prosthetic valve into a lumen of a delivery system. The valve recoil adapter can counteract recoil of a compressed prosthetic valve, and maintain the valve at its desired crimp diameter. An integrated bioprosthesis/delivery system is provided for delivering a bioprosthesis to a target area within a body lumen is provided. The delivery system includes a valve covering member and a compressing member, which compresses the valve covering member to surround, hold, and/or compress the valve during delivery to the target area.

公开(公告)号：US20250134487A1

公开(公告)日：2025-05-01

申请号：US19009694

申请日：2025-01-03

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Yaron Keidar

IPC: A61B8/06 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/022 ,  A61B5/0245 ,  A61B5/08 ,  A61B5/113 ,  A61B7/00 ,  A61B8/00 ,  A61B8/02 ,  A61B8/04 ,  A61B8/08

Abstract: Disclosed are processes for monitoring heart valve function involving determining an effective orifice area of a mitral valve of a patient's heart based on isolated forward-flow and/or regurgitant-flow components and patient-specific calibration data, wherein a patient-specific mitral valve pressure gradient can be determined based on the determined effective orifice area.

公开(公告)号：US20240216138A1

公开(公告)日：2024-07-04

申请号：US18611044

申请日：2024-03-20

Applicant: Edwards Lifesciences Corporation

Inventor： Yaron Keidar

IPC: A61F2/24 ,  A61B17/064

CPC classification number: A61F2/2427 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61B17/064 ,  A61F2/2463

Abstract: A method of replacing a native heart valve utilizing a support structure comprising a first fastener, a second faster, a first leaflet brace, and a second leaflet brace. The first leaflet brace is configured to be advanced over a first guide wire to be adjacent to a portion of a first native leaflet. The second leaflet brace is configured to be advanced over a second guide wire to be adjacent to a portion of a second native leaflet. The first fastener and the second fastener are configured to be advanced over the first and second guide wires to respectively engage with first and second ends of the first leaflet brace and the second leaflet brace. A replacement heart valve is deployed within the native heart valve, thereby capturing the first and second leaflets between the support structure and the replacement heart valve.

公开(公告)号：US20220104940A1

公开(公告)日：2022-04-07

申请号：US17553566

申请日：2021-12-16

Applicant: Edwards Lifesciences Corporation

Inventor： Matthew A. Peterson ,  Seung-Beom Yi ,  Siddharth Vad ,  Travis Zenyo Oba ,  Lauren R. Freschauf ,  Amanda French ,  Yaron Keidar ,  Yuanlong Du ,  Gregory Bak-Boychuk ,  Kevin M. Golemo ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity and a valve body. The expandable frame can include a frame body and a supplemental frame. The valve body can include a plurality of leaflets and one or more intermediate components. The one or more intermediate components can couple at least a portion of the leaflets to the expandable frame. The prosthesis can include an annular flap positioned around an exterior of the expandable frame.

公开(公告)号：US11103348B2

公开(公告)日：2021-08-31

申请号：US16600362

申请日：2019-10-11

Applicant: Edwards Lifesciences Corporation

Inventor： Mark A. Konno ,  Yaron Keidar

IPC: A61F2/24 ,  A61F2/958

Abstract: The invention is a cardiac implant, and associated methods therefore, configured to repair and/or replace a native heart valve, and having a support frame configured to be reshaped into an expanded/changed form in order to receive and/or support an expandable prosthetic heart valve therein. The implant may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace/repair a native valve (or other prosthetic heart valve), but to assume a generally non-rigid and/or expanded/expandable form when subjected to an outward force such as that provided by a dilation balloon. The implant may be configured to have a generally D-shaped configuration when initially implanted, but to assume a generally circular form when subjected to an outward force such as that provided by a dilation balloon.

公开(公告)号：US11033386B2

公开(公告)日：2021-06-15

申请号：US16351402

申请日：2019-03-12

Applicant: Edwards Lifesciences Corporation

Inventor： Yaron Keidar

IPC: A61F2/24 ,  A61B17/064

Abstract: A system for repairing a native heart valve can comprise a first fastener, a second faster, a first leaflet brace, and a second leaflet brace. The first leaflet brace can be configured to extend partially around a first native leaflet. The second leaflet brace can be configured to extend partially around a second native leaflet. The first fastener can be configured to be deployed on respective first end portions of the first and second braces so as to connect the first end portions to each other. The second fastener can be configured to be deployed on respective second end portions of the first and second braces so as to connect the second end portions to each other. When the first end portions are connected to each other and the second end portions are connected to each other, the first and second leaflet braces encircle the first and second native leaflets.

公开(公告)号：US10478301B2

公开(公告)日：2019-11-19

申请号：US15498213

申请日：2017-04-26

Applicant: Edwards Lifesciences Corporation

Inventor： Mark A. Konno ,  Yaron Keidar

IPC: A61F2/24 ,  A61F2/958

Abstract: The invention is a cardiac implant, and associated methods therefore, configured to repair and/or replace a native heart valve, and having a support frame configured to be reshaped into an expanded/changed form in order to receive and/or support an expandable prosthetic heart valve therein. The implant may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace/repair a native valve (or other prosthetic heart valve), but to assume a generally non-rigid and/or expanded/expandable form when subjected to an outward force such as that provided by a dilation balloon. The implant may be configured to have a generally D-shaped configuration when initially implanted, but to assume a generally circular form when subjected to an outward force such as that provided by a dilation balloon.

公开(公告)号：US20190328515A1

公开(公告)日：2019-10-31

申请号：US16506886

申请日：2019-07-09

Applicant: Edwards Lifesciences Corporation

Inventor： Matthew A. Peterson ,  Seung-Beom Yi ,  Siddharth Vad ,  Travis Zenyo Oba ,  Lauren R. Freschauf ,  Amanda French ,  Yaron Keidar ,  Yuanlong Du ,  Gregory Bak-Boychuk ,  Kevin M. Golemo ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: A heart valve prosthesis for replacing a native mitral valve includes a self-expanding frame with a plurality of anchoring members disposed along the lower region. A valve body is positioned within the self-expanding frame and includes a plurality of leaflets configured to allow blood flow through the self-expanding frame in only one direction. A skirt surrounds the self-expanding frame and is spaced apart therefrom for contacting surrounding tissue and impeding blood flow around the self-expanding frame. The skirt may be reinforced with wires to help maintain a desired shape. The leaflets in the valve body are preferably connected to the self-expanding frame through one or more intermediate components such that the valve body is spaced radially inwardly from an inner surface of the self-expanding frame.

公开(公告)号：US20190125296A1

公开(公告)日：2019-05-02

申请号：US16171501

申请日：2018-10-26

Applicant: Edwards Lifesciences Corporation

Inventor： Yaron Keidar

IPC: A61B8/06 ,  A61B8/00 ,  A61B5/0245 ,  A61B5/0205 ,  A61B5/00 ,  A61B7/00

Abstract: The invention is a device, system, and method for monitoring function of heart valves. The invention includes a disposable patch having simple transducers and simple processing for monitoring heart valve performance via echo Doppler and processing the data to determine blood flow velocities and/or blood flow gradients.

公开(公告)号：US10085837B2

公开(公告)日：2018-10-02

申请号：US14809049

申请日：2015-07-24

Applicant: Edwards Lifesciences Corporation

Inventor： Yaron Keidar ,  Wesley V. Adzich ,  Dan Rottenberg ,  Boaz Manash ,  Alon Nahshon

IPC: A61F2/24

Abstract: An active annuloplasty ring holder having a template that can be folded or pivoted to the side allowing the template to align longitudinally with the handle and enter the patient's chest through a small incision. The holder may include a mechanism to remotely detach sutures fastening the ring to the holder, thereby detaching the ring while avoiding the risk associated with introducing a scalpel into the operating field. A detachment mechanism may include a movable pin actuated by a pull wire that releases a plurality of holding sutures, or a hot wire, knives, or pull wire that severs the sutures. The holder may have a built-in light source for better visualization of the ring inside the heart. The holder may also have an optical means of visualizing the inside of the heart from the proximal end of the handle.