公开(公告)号：US20160030430A1

公开(公告)日：2016-02-04

申请号：US14806174

申请日：2015-07-22

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Roch Boivin ,  Eric Carlson ,  Atsushi Endo ,  Hans Hansen ,  Lynn D. Hawkins ,  Sally Ishizaka ,  Matthew Mackey ,  Sridhar Narayan ,  Takashi Satoh ,  Shawn Schiller

IPC: A61K31/519

CPC classification number: C07D471/04 ,  A61K31/519 ,  A61K31/55 ,  C07D487/04 ,  Y02P20/582

Abstract: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis