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公开(公告)号：US20180273532A1
公开(公告)日：2018-09-27
申请号：US15841767
申请日：2017-12-14
发明人： Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号： C07D471/04 , A61K31/55 , C07D487/04 , A61K31/519
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：US20180354939A1
公开(公告)日：2018-12-13
申请号：US16108964
申请日：2018-08-22
发明人： J. Eric Carlson , Hans Hansen , Lynn Hawkins , Sally Ishizaka , Matthew Mackey , Shawn Schiller , Chikako Ogawa , Heather Davis , Atsushi Endo
IPC分类号： C07D417/14 , C07D403/14 , C07D413/04 , C07D401/10 , C07D401/14 , C07D471/10 , C07D487/10 , C07D471/04 , C07D215/48 , C12Q1/6897 , G01N33/50 , C07D451/04 , C07D487/04 , C07D493/10 , C07D413/14
CPC分类号： C07D417/14 , C07B2200/07 , C07D215/48 , C07D401/10 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14 , C07D451/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D493/10 , C12Q1/6897 , G01N33/5023 , G01N33/5047
摘要： Embodiments of the disclosure relate to selectively substituted quinolone compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：US09850242B2
公开(公告)日：2017-12-26
申请号：US15233520
申请日：2016-08-10
发明人： Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号： A01N43/90 , A61K31/519 , C07D471/04 , C07D487/04 , A61K31/55
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：US20160339032A1
公开(公告)日：2016-11-24
申请号：US15233520
申请日：2016-08-10
发明人： Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号： A61K31/519 , A61K31/55
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis
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公开(公告)号：US09446046B2
公开(公告)日：2016-09-20
申请号：US14806174
申请日：2015-07-22
发明人： Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号： A01N43/90 , A61K31/519 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：US11130758B2
公开(公告)日：2021-09-28
申请号：US16845594
申请日：2020-04-10
发明人： Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号： C07D487/04 , C07D471/04 , A61K31/519 , A61K31/55
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：USRE47193E1
公开(公告)日：2019-01-08
申请号：US15668887
申请日：2017-08-04
发明人： J. Eric Carlson , Hans Hansen , Lynn Hawkins , Sally Ishizaka , Matthew Mackey , Shawn Schiller , Chikako Ogawa , Heather Davis , Atsushi Endo
IPC分类号： C07D413/04 , C07D401/14 , C07D403/14 , C07D401/10 , C07D413/14 , C07D417/14 , C07D215/48 , C07D471/04 , C07D471/10 , C07D487/10 , C12Q1/6897 , C07D493/10 , C07D487/04 , G01N33/50 , C07D451/04
摘要： Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：US09663486B2
公开(公告)日：2017-05-30
申请号：US14908164
申请日：2014-10-14
发明人： Roch Boivin , Hans Hansen , Sally Ishizaka , Matthew Mackey , Shawn Schiller , Chikako Ogawa , Sridhar Narayan , Peter Bertinato , Gregory Berger , Atsushi Endo , Robert T. Yu , Lynn Hawkins
IPC分类号： C07D401/02 , C07D413/14 , C07D471/04 , C07D401/14 , C07D417/14 , C07D401/04
CPC分类号： C07D401/02 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：US09428495B2
公开(公告)日：2016-08-30
申请号：US14513556
申请日：2014-10-14
发明人： Eric Carlson , Hans Hansen , Lynn Hawkins , Sally Ishizaka , Matthew Mackey , Shawn Schiller , Chikako Ogawa , Heather Davis , Atsushi Endo
IPC分类号： C07D413/04 , C07D413/14 , C07D401/10 , C07D401/14 , C07D403/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/10 , C07D215/48
CPC分类号： C07D417/14 , C07B2200/07 , C07D215/48 , C07D401/10 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14 , C07D451/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D493/10 , C12Q1/6897 , G01N33/5023 , G01N33/5047
摘要： Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
摘要翻译： 本公开的实施方案涉及用作Toll样受体7和/或8的拮抗剂或抑制剂的选择性取代的喹啉化合物及其在有效治疗系统性红斑狼疮（SLE）和狼疮性肾炎的药物组合物中的用途。
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公开(公告)号：US20160030430A1
公开(公告)日：2016-02-04
申请号：US14806174
申请日：2015-07-22
发明人： Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号： A61K31/519
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis
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