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公开(公告)号：US20150353494A1
公开(公告)日：2015-12-10
申请号：US14742481
申请日：2015-06-17
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: C07D213/64 , C07D401/12 , C07D498/08 , C07D405/14
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US20150065483A1
公开(公告)日：2015-03-05
申请号：US14536162
申请日：2014-11-07
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Edward James Olhava , Richard Chesworth , Kenneth William Duncan
IPC: C07D401/12 , C07D401/14 , C07D405/14 , C07D471/04
CPC classification number: C07D401/12 , A61P35/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.
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公开(公告)号：US08962620B2
公开(公告)日：2015-02-24
申请号：US14070675
申请日：2013-11-04
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Edward James Olhava , Richard Chesworth , Kenneth William Duncan
IPC: C07D471/04 , A61K31/4738 , A61P35/00 , C07D401/12 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14
CPC classification number: C07D401/12 , A61P35/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.
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公开(公告)号：US20140057891A1
公开(公告)日：2014-02-27
申请号：US14070675
申请日：2013-11-04
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Edward James Olhava , Richard Chesworth , Kenneth William Duncan
IPC: C07D471/04 , C07D401/14 , C07D405/14 , C07D401/12
CPC classification number: C07D401/12 , A61P35/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.
Abstract translation: 本发明涉及取代的6,5-稠合双环杂芳基化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。
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公开(公告)号：US20230357208A1
公开(公告)日：2023-11-09
申请号：US18170319
申请日：2023-02-16
Applicant: Epizyme, Inc.
Inventor： Darren Martin Harvey , John Emmerson Campbell , Kenneth William Duncan
IPC: C07D405/12 , C07C311/49 , C07D205/04 , C07D207/08 , C07D211/24 , C07D213/54 , C07D223/04 , C07D231/12 , C07D233/64 , C07D241/04 , C07D257/04 , C07D265/30 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12
CPC classification number: C07D405/12 , C07C311/49 , C07D205/04 , C07D207/08 , C07D211/24 , C07D213/54 , C07D223/04 , C07D231/12 , C07D233/64 , C07D241/04 , C07D257/04 , C07D265/30 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12
Abstract: The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US09206157B2
公开(公告)日：2015-12-08
申请号：US14733690
申请日：2015-06-08
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Edward James Olhava , Richard Chesworth , Kenneth William Duncan
IPC: C07D401/12 , C07D471/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14
CPC classification number: C07D401/12 , A61P35/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.
Abstract translation: 本发明涉及取代的6,5-稠合双环杂芳基化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。
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公开(公告)号：US20130317026A1
公开(公告)日：2013-11-28
申请号：US13938067
申请日：2013-07-09
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Edward James Olhava , Richard Chesworth , Kenneth William Duncan
IPC: C07D401/12
CPC classification number: C07D401/12 , A61P35/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.
Abstract translation: 本发明涉及取代的6,5-稠合双环杂芳基化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。
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公开(公告)号：US20130123234A1
公开(公告)日：2013-05-16
申请号：US13722807
申请日：2012-12-20
Applicant: EPIZYME, INC. , EISAI R&D MANAGEMENT CO., LTD.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: C07D213/64 , C07D401/12 , C07D491/08 , C07D417/12 , C07D491/107 , C07D405/14 , C07D409/12
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US11685732B2
公开(公告)日：2023-06-27
申请号：US16766890
申请日：2018-11-29
Applicant: Epizyme, Inc.
Inventor： Darren Martin Harvey , John Emmerson Campbell , Kenneth William Duncan
IPC: C07D403/12 , C07D309/06 , C07D309/08 , C07D231/12 , C07D231/56 , C07D471/10 , C07D263/28 , C07D263/50 , C07D205/04 , C07D265/30 , C07D207/08 , C07D275/03 , C07C311/19 , C07C311/32 , C07C311/49 , C07C255/00 , C07C307/02 , C07C317/50 , A61K31/40 , A61K31/18 , A61K31/165 , A61P35/00 , C07D405/12 , C07D211/24 , C07D213/54 , C07D223/04 , C07D233/64 , C07D241/04 , C07D257/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12
CPC classification number: C07D405/12 , C07C311/49 , C07D205/04 , C07D207/08 , C07D211/24 , C07D213/54 , C07D223/04 , C07D231/12 , C07D233/64 , C07D241/04 , C07D257/04 , C07D265/30 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12
Abstract: The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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公开(公告)号：US11672800B2
公开(公告)日：2023-06-13
申请号：US16606833
申请日：2018-04-20
Applicant: Epizyme, Inc.
Inventor： John Emmerson Campbell , Kenneth William Duncan , Maria Alejandra Raimondi , Christine Klaus , Elayne Penebre
IPC: A61K31/505 , A61K31/506 , A61P35/00 , A61K31/203 , A61K31/4375 , A61K31/44 , A61K31/496 , A61K31/517 , A61K31/519 , A61K31/706
CPC classification number: A61K31/506 , A61K31/203 , A61K31/4375 , A61K31/44 , A61K31/496 , A61K31/517 , A61K31/519 , A61K31/706 , A61P35/00
Abstract: The present disclosure relates to a method of preventing or treating a cancer via administering an EHMT2 inhibitor or a combination comprising an EHMT2 inhibitor compound and one or more additional therapeutic agent disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds or combinations for research or other non-therapeutic purposes.
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