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11.发明申请QUINOXALINE DERIVATIVES AND THEIR USE FOR TREATING BENIGN AND MALIGNANT TUMOUR DISORDERS 失效喹啉衍生物及其用于治疗恶性肿瘤恶病质的用途公开(公告)号：US20100266538A1
公开(公告)日：2010-10-21
申请号：US12731243
申请日：2010-03-25
申请人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Tilmann Schuster , Emmanuel Polymeropoulos , Michael Czech , Eckhard Claus
发明人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Tilmann Schuster , Emmanuel Polymeropoulos , Michael Czech , Eckhard Claus
IPC分类号： A61K38/21 , C07D241/44 , A61K31/498 , A61K38/46 , A61K38/14 , A61K33/24 , A61K31/573 , A61P35/00 , A61P35/04
CPC分类号： C07D241/44 , C07D401/12 , C07D403/04 , C07D409/12 , C07D413/12
摘要： The invention provides quinoxalines of the general formula I which are used as medicaments preferably for treating tumour disorders, in particular in cases of drug resistance to other active compounds and in cases of metastasic carcinoma. The possible applications are not limited to tumour disorders.
摘要翻译： 本发明提供了通式I的喹喔啉，其用作优选用于治疗肿瘤病症的药物，特别是在对其它活性化合物的耐药性和转移性癌症的情况下。 可能的应用不限于肿瘤病症。
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12.发明授权公开(公告)号：US08507486B2
公开(公告)日：2013-08-13
申请号：US13455435
申请日：2012-04-25
申请人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
发明人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
IPC分类号： A61K31/495
CPC分类号： C07D471/04
摘要： 1-ethyl-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2.3-b]pyrazine-6-yl]thiourea which HAS activity to the modulation of misdirected cellular signal transduction processes such as tyrosine kinases, serine/threonine kinases and/or lipid kinases.
摘要翻译： 1-乙基-3- [3-（1-甲基-1H-吡唑-4-基） - 吡啶并[2,3-b]吡嗪-6-基]硫脲，其对调制错误定向的细胞信号转导过程具有活性 酪氨酸激酶，丝氨酸/苏氨酸激酶和/或脂质激酶。
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公开(公告)号：US08217042B2
公开(公告)日：2012-07-10
申请号：US11558503
申请日：2006-11-10
申请人： Eckhard Claus , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Michael Czech , Tilmann Schuster
发明人： Eckhard Claus , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Michael Czech , Tilmann Schuster
IPC分类号： A61K31/4965
CPC分类号： A61K31/4985 , A61K31/5377 , A61K31/675 , A61K31/695 , C07D487/04
摘要： The invention relates to pyrido[2,3-b]pyrazines of the general formulae (I) and (II), and to their preparation and use as medicaments, especially for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
摘要翻译： 本发明涉及通式（I）和（II）的吡啶并[2,3-b]吡嗪及其作为药物的制备和用途，特别是用于治疗基于病理细胞增殖的恶性疾病和其它病症。
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公开(公告)号：US20070149484A1
公开(公告)日：2007-06-28
申请号：US11558503
申请日：2006-11-10
申请人： Eckhard Claus , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Michael Czech , Tilmann Schuster
发明人： Eckhard Claus , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Michael Czech , Tilmann Schuster
IPC分类号： A61K31/675 , C07D487/02 , A61K31/498
CPC分类号： A61K31/4985 , A61K31/5377 , A61K31/675 , A61K31/695 , C07D487/04
摘要： The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general formulae (I) and (II), and to their preparation and use as medicaments, especially for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
摘要翻译： 本发明涉及通式（I）和（II）的新型吡啶并[2,3-b]吡嗪衍生物及其作为药物的制备和用途，特别是用于治疗基于病理细胞的恶性疾病和其它病症 激增。
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![Modulating signal transduction pathways with 1-ethyl-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2.3-B]pyrazine-6-yl]thiourea](/abs-image/US/2013/12/10/US08604196B2/abs.jpg.150x150.jpg)
15.发明授权Modulating signal transduction pathways with 1-ethyl-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2.3-B]pyrazine-6-yl]thiourea 失效用1-乙基-3- [3-（1-甲基-1H-吡唑-4-基） - 吡啶并[2,3-B]吡嗪-6-基]硫脲调制信号转导途径公开(公告)号：US08604196B2
公开(公告)日：2013-12-10
申请号：US13542101
申请日：2012-07-05
申请人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
发明人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
IPC分类号： C07D495/00
CPC分类号： C07D471/04
摘要： A method of modulating one or more of ras-Raf-Mek-Erk signal transduction pathway, PI3K-Akt signal transduction pathway and SAPK signal transduction pathway with 1-ethyl-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazine-6-yl]thiourea, its geometric isomer, or its tautomer.
摘要翻译： 一种调节ras-Raf-Mek-Erk信号转导途径，PI3K-Akt信号转导途径和SAPK信号转导途径中的一种或多种与1-乙基-3- [3-（1-甲基-1H-吡唑-4-基） - 基） - 吡啶并[2,3-b]吡嗪-6-基]硫脲，其几何异构体或其互变异构体。
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公开(公告)号：US20120252760A1
公开(公告)日：2012-10-04
申请号：US13523968
申请日：2012-06-15
申请人： Eckhard Claus , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Michael Czech , Tilmann Schuster
发明人： Eckhard Claus , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Michael Czech , Tilmann Schuster
IPC分类号： A61K31/4985 , C07F7/18 , C07F9/6561 , A61P1/16 , A61K31/695 , A61K31/675 , A61P17/06 , A61P9/10 , C07D471/04 , A61K31/5377
CPC分类号： A61K31/4985 , A61K31/5377 , A61K31/675 , A61K31/695 , C07D487/04
摘要： The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general formulae (I) and (II), and to their preparation and use as medicaments, especially for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
摘要翻译： 本发明涉及通式（I）和（II）的新型吡啶并[2,3-b]吡嗪衍生物及其作为药物的制备和用途，特别是用于治疗基于病理细胞的恶性疾病和其它病症 激增。
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17.发明申请公开(公告)号：US20090275534A1
公开(公告)日：2009-11-05
申请号：US12117942
申请日：2008-05-09
申请人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
发明人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
IPC分类号： A61K31/675 , C07D471/04 , A61K31/4985 , A61K31/536 , A61K31/54 , A61K31/5513 , C12N5/02
CPC分类号： C07D471/04
摘要： The invention relates to pyrido[2,3-b]pyrazine compounds of general formulae (Ia) and (Ib), to their preparation and use, for example, for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
摘要翻译： 本发明涉及通式（Ia）和（Ib）的吡啶并[2,3-b]吡嗪化合物及其制备和用途，例如用于治疗基于病理细胞增殖的恶性病症和其它病症。
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![Modulating signal transduction pathways with substituted pyridol [2,3-b] pyrazines](/abs-image/US/2013/09/17/US08536332B2/abs.jpg.150x150.jpg)
18.发明授权Modulating signal transduction pathways with substituted pyridol [2,3-b] pyrazines 失效用取代的吡啶并[2,3-b]吡嗪调节信号转导通路公开(公告)号：US08536332B2
公开(公告)日：2013-09-17
申请号：US13455187
申请日：2012-04-25
申请人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
发明人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
IPC分类号： C07D471/00
CPC分类号： C07D471/04
摘要： Method of modulating ras-Raf-Mek-Erk signal transduction pathway, PI3K-Akt signal transduction pathway and/or SAPK signal transduction pathway with a pyrido[2,3-b]pyrazine of formula (Ia).
摘要翻译： 用式（Ia）的吡啶并[2,3-b]吡嗪调节ras-Raf-Mek-Erk信号转导途径，PI3K-Akt信号转导途径和/或SAPK信号转导途径的方法。
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19.发明授权Quinoxaline derivatives and their use for treating benign and malignant tumour disorders 失效喹喔啉衍生物及其用于治疗良性和恶性肿瘤疾病的用途公开(公告)号：US08394801B2
公开(公告)日：2013-03-12
申请号：US12731243
申请日：2010-03-25
申请人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Tilmann Schuster , Emmanuel Polymeropoulos , Michael Czech , Eckhard Claus
发明人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Tilmann Schuster , Emmanuel Polymeropoulos , Michael Czech , Eckhard Claus
IPC分类号： A61K31/495
CPC分类号： C07D241/44 , C07D401/12 , C07D403/04 , C07D409/12 , C07D413/12
摘要： The invention provides quinoxalines of the general formula I which are used as medicaments preferably for treating tumour disorders, in particular in cases of drug resistance to other active compounds and in cases of metastasic carcinoma. The possible applications are not limited to tumour disorders.
摘要翻译： 本发明提供了通式I的喹喔啉，其用作优选用于治疗肿瘤病症的药物，特别是在对其它活性化合物的耐药性和转移性癌症的情况下。 可能的应用不限于肿瘤病症。
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公开(公告)号：US20120277219A1
公开(公告)日：2012-11-01
申请号：US13542101
申请日：2012-07-05
申请人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
发明人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
IPC分类号： A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P35/00 , A61P29/00 , A61P19/02 , A61P31/18 , A61P25/28 , A61P17/06 , A61P37/02 , A61P35/02 , A61P3/10 , A61P37/06 , A61P11/06 , A61P1/00 , A61P9/10 , A61P9/00 , A61P13/12 , A61P7/02 , A61P3/04 , A61P9/12 , A61K31/538
CPC分类号： C07D471/04
摘要： The invention relates to pyrido[2,3-b]pyrazine compounds of general formulae (Ia) and (Ib), to their preparation and use, for example, for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
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