公开(公告)号：US20210207124A1

公开(公告)日：2021-07-08

申请号：US17211484

申请日：2021-03-24

Applicant: Exosome Diagnostics, Inc.

Inventor： Johan Karl Olov SKOG ,  Leileata M. RUSSO

IPC: C12N15/10

Abstract: A method for extracting nucleic acids from a biological sample by isolating nucleic acid-containing particles from the biological sample by one or more centrifugation procedures, performing one or more steps to mitigate adverse factors that prevent or might prevent high quality nucleic acid extraction, and extracting nucleic acids from the isolated particles. The centrifugation procedures are performed at a speed not exceeding about 200,000 g. The extracted nucleic acids contain both 18S and 28S rRNA.

公开(公告)号：US20200032243A1

公开(公告)日：2020-01-30

申请号：US16595278

申请日：2019-10-07

Applicant: Exosome Diagnostics, Inc.

Inventor： Johan Karl Olov SKOG ,  Daniel ENDERLE ,  Aparna RAMACHANDRAN ,  Haoheng YAN ,  Emily BERGHOFF ,  Tai-Fen WEI ,  Mikkel NOERHOLM

IPC: C12N15/10

Abstract: The invention provides novel methods and kits for isolating nucleic acids from biological samples, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles, and for extracting nucleic acids from the microvesicles and/or from the biological samples.

公开(公告)号：US20250163510A1

公开(公告)日：2025-05-22

申请号：US18839547

申请日：2023-02-21

Applicant: Exosome Diagnostics, Inc. ,  The Brigham and Women's Hospital, Inc.

Inventor： Johan Karl Olov SKOG ,  Brian C. HAYNES ,  Elliot HALLMARK ,  James HURLEY ,  Jamil AZZI

IPC: C12Q1/6883 ,  G01N33/68

Abstract: The present disclosure relates to methods of identifying and treating kidney rejection in a subject comprising analyzing RNA, including microvesicular RNA.

公开(公告)号：US20220412971A1

公开(公告)日：2022-12-29

申请号：US17761398

申请日：2020-09-18

Applicant: Exosome Diagnostics, Inc.

Inventor： Johan Karl Olov SKOG ,  Olubode A. OGUNLUSI ,  Robert Raymond KITCHEN ,  Douglas ROBERTS ,  Wei YU

IPC: G01N33/543 ,  C12N15/10

Abstract: The present disclosure relates to compositions, methods and kits for the isolation of extracellular vesicles. The compositions, methods and kits can comprise a high-density liquid reagent that facilitates the sequestration of extracellular vesicles bound to magnetic beads.

公开(公告)号：US20200056244A1

公开(公告)日：2020-02-20

申请号：US16375237

申请日：2019-04-04

Applicant: Exosome Diagnostics, Inc.

Inventor： Johan Karl Olov SKOG ,  Mikkel NOERHOLM

IPC: C12Q1/6886

Abstract: The present invention relates generally to the field of biomarker analysis, particularly determining gene expression signatures from urine samples. The disclosure provides compositions, kits and methods for diagnosing a prostate disorder such as prostate cancer in a male subject.