公开(公告)号：US20210171934A1

公开(公告)日：2021-06-10

申请号：US16893966

申请日：2020-06-05

Applicant: Exosome Diagnostics, Inc.

Inventor： Daniel ENDERLE ,  Aparna RAMACHANDRAN ,  Haoheng YAN ,  Emily BERGHOFF ,  Tai-Fen WEI ,  Mikkel NOERHOLM ,  Johan Karl Olov SKOG

IPC: C12N15/10 ,  C12Q1/6806

Abstract: The invention provides novel methods for isolating microvesicles from a biological sample and for extracting nucleic acids from the microvesicles.

公开(公告)号：US20200149036A1

公开(公告)日：2020-05-14

申请号：US16473604

申请日：2018-01-02

Applicant: Exosome Diagnostics, Inc.

Inventor： Daniel ENDERLE ,  Johan SKOG ,  Phillipp TORKLER ,  Alexandra SPIEL ,  Mikkel NOERHOLM

IPC: C12N15/10 ,  C12Q1/6806 ,  C12Q1/6874

Abstract: The invention provides a series of steps to distinguish RNA from DNA in assays downstream of a combined isolation. This enables a wide diversity of RNAs and/or DNAs, to be efficiently detected.

公开(公告)号：US20210403881A1

公开(公告)日：2021-12-30

申请号：US17295287

申请日：2019-11-20

Applicant: Exosome Diagnostics, Inc.

Inventor： Georg STOLL ,  Daniel ENDERLE ,  Mikkel NOERHOLM ,  Johan Karl Olov SKOG

IPC: C12N7/00 ,  C12Q1/70 ,  C12N15/10

Abstract: The present disclosure provides compositions, methods and kits for internal controls of microvesicle isolations. The compositions, methods and kits can comprise enveloped viruses, including, but not limited to, inactive mouse hepatitis virus (MHV).

公开(公告)号：US20190284548A1

公开(公告)日：2019-09-19

申请号：US16301176

申请日：2017-05-15

Applicant: Exosome Diagnostics, Inc.

Inventor： Georg STOLL ,  Daniel ENDERLE ,  Mikkel NOERHOLM ,  Johan Karl Olov SKOG

IPC: C12N15/10 ,  C12N15/11

Abstract: The invention provides novel methods and kits for fully automated high-throughput method for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles, novel methods and kits for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles that do not require the use of phenol or chloroform, and for extracting nucleic acids from the extracellular vesicles and/or from the biological samples.

公开(公告)号：US20220355290A1

公开(公告)日：2022-11-10

申请号：US17621084

申请日：2020-06-24

Applicant: Exosome Diagnostics, Inc.

Inventor： Georg STOLL ,  Frank NUSS ,  Daniel ENDERLE ,  Mikkel NOERHOLM

IPC: B01L3/00 ,  A61B10/00

Abstract: Described herein are various inventions and embodiments thereof, directed to systems, devices, and methods for separating a sample. Embodiments of sample collection devices disclosed herein may maintain separation of different volumes of sample during collecting, handling, and accessing of the sample. A sample collection device, in some embodiments, may comprise an enclosure defining a first chamber, a second chamber, and a partition therebetween configured to separate the first chamber and the second chamber. An assembly coupled to the partition may be configured to transition between an open configuration and a closed configuration based on fluid and gas flow through the assembly.

公开(公告)号：US20210238582A1

公开(公告)日：2021-08-05

申请号：US17074040

申请日：2020-10-19

Applicant: Exosome Diagnostics, Inc.

Inventor： Georg STOLL ,  Daniel ENDERLE ,  Mikkel NOERHOLM ,  Johan Karl Olov SKOG

IPC: C12N15/10 ,  C12N15/11

Abstract: The invention provides novel methods and kits for fully automated high-throughput method for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles, novel methods and kits for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles that do not require the use of phenol or chloroform, and for extracting nucleic acids from the extracellular vesicles and/or from the biological samples.

公开(公告)号：US20200032243A1

公开(公告)日：2020-01-30

申请号：US16595278

申请日：2019-10-07

Applicant: Exosome Diagnostics, Inc.

Inventor： Johan Karl Olov SKOG ,  Daniel ENDERLE ,  Aparna RAMACHANDRAN ,  Haoheng YAN ,  Emily BERGHOFF ,  Tai-Fen WEI ,  Mikkel NOERHOLM

IPC: C12N15/10

Abstract: The invention provides novel methods and kits for isolating nucleic acids from biological samples, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles, and for extracting nucleic acids from the microvesicles and/or from the biological samples.