公开(公告)号：US20200032243A1

公开(公告)日：2020-01-30

申请号：US16595278

申请日：2019-10-07

Applicant: Exosome Diagnostics, Inc.

Inventor： Johan Karl Olov SKOG ,  Daniel ENDERLE ,  Aparna RAMACHANDRAN ,  Haoheng YAN ,  Emily BERGHOFF ,  Tai-Fen WEI ,  Mikkel NOERHOLM

IPC: C12N15/10

Abstract: The invention provides novel methods and kits for isolating nucleic acids from biological samples, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles, and for extracting nucleic acids from the microvesicles and/or from the biological samples.

公开(公告)号：US20210171934A1

公开(公告)日：2021-06-10

申请号：US16893966

申请日：2020-06-05

Applicant: Exosome Diagnostics, Inc.

Inventor： Daniel ENDERLE ,  Aparna RAMACHANDRAN ,  Haoheng YAN ,  Emily BERGHOFF ,  Tai-Fen WEI ,  Mikkel NOERHOLM ,  Johan Karl Olov SKOG

IPC: C12N15/10 ,  C12Q1/6806

Abstract: The invention provides novel methods for isolating microvesicles from a biological sample and for extracting nucleic acids from the microvesicles.

公开(公告)号：US20190211106A1

公开(公告)日：2019-07-11

申请号：US16261241

申请日：2019-01-29

Applicant: Exosome Diagnostics, Inc.

Inventor： Johan Karl Olov SKOG ,  Emily BERGHOFF ,  Lori LOGUIDICE

IPC: C07K16/28 ,  C07K14/485 ,  C07K14/71 ,  C12Q1/6886 ,  C12N15/113 ,  G01N33/574

CPC classification number: C07K16/2863 ,  A61K47/6849 ,  C07K14/485 ,  C07K14/71 ,  C07K2317/76 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/57492 ,  G01N2333/71 ,  G01N2800/52

Abstract: The present invention features a novel EGFR variant, EGFRvVI, and methods for detecting the novel EGFR variant. The novel EGFR variant is preferentially expressed in some cancers. Methods for detecting EGFRvVI may aid in the diagnosis, prognosis, and therapeutic assessment of a subject.