公开(公告)号：US20210171934A1

公开(公告)日：2021-06-10

申请号：US16893966

申请日：2020-06-05

Applicant: Exosome Diagnostics, Inc.

Inventor： Daniel ENDERLE ,  Aparna RAMACHANDRAN ,  Haoheng YAN ,  Emily BERGHOFF ,  Tai-Fen WEI ,  Mikkel NOERHOLM ,  Johan Karl Olov SKOG

IPC: C12N15/10 ,  C12Q1/6806

Abstract: The invention provides novel methods for isolating microvesicles from a biological sample and for extracting nucleic acids from the microvesicles.

公开(公告)号：US20190211106A1

公开(公告)日：2019-07-11

申请号：US16261241

申请日：2019-01-29

Applicant: Exosome Diagnostics, Inc.

Inventor： Johan Karl Olov SKOG ,  Emily BERGHOFF ,  Lori LOGUIDICE

IPC: C07K16/28 ,  C07K14/485 ,  C07K14/71 ,  C12Q1/6886 ,  C12N15/113 ,  G01N33/574

CPC classification number: C07K16/2863 ,  A61K47/6849 ,  C07K14/485 ,  C07K14/71 ,  C07K2317/76 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/57492 ,  G01N2333/71 ,  G01N2800/52

Abstract: The present invention features a novel EGFR variant, EGFRvVI, and methods for detecting the novel EGFR variant. The novel EGFR variant is preferentially expressed in some cancers. Methods for detecting EGFRvVI may aid in the diagnosis, prognosis, and therapeutic assessment of a subject.

公开(公告)号：US20220112555A1

公开(公告)日：2022-04-14

申请号：US17560759

申请日：2021-12-23

Applicant: Exosome Diagnostics, Inc. ,  The Brigham and Women's Hospital

Inventor： Johan Karl Olov SKOG ,  Jamil AZZI

IPC: C12Q1/6876 ,  C12Q1/686

Abstract: The invention relates generally to the use of microvesicle RNA signatures for diagnosis, predicting, and/or to monitor treatment efficacy, including patients who are candidates for renal transplant and/or who have received a renal transplant.

公开(公告)号：US20190093172A1

公开(公告)日：2019-03-28

申请号：US16092358

申请日：2017-04-17

Applicant: Exosome Diagnostics, Inc.

Inventor： Johan Karl Olov SKOG ,  Mikkel NOERHOLM ,  James HURLEY ,  Elena CASTELLANOS-RIZALDOS ,  Kay BRINKMAN

IPC: C12Q1/6886 ,  C12N15/10 ,  C12Q1/686 ,  G16H50/20

Abstract: The present invention relates generally to the field of biomarker analysis, particularly determining gene expression signatures from biological samples, including plasma samples.

公开(公告)号：US20250075258A1

公开(公告)日：2025-03-06

申请号：US18579636

申请日：2022-07-18

Applicant: Exosome Diagnostics, Inc. ,  Trustees of Tufts College

Inventor： Sudipto Kumar CHAKRABORTTY ,  Steven LANG ,  Yevgenia Leona Khodor TOLAN ,  Martina RAUSCHER ,  Vasisht TADIGOTLA ,  Wei YU ,  Athena S. PAPAS ,  Johan Karl Olov SKOG ,  Brian C. HAYNES ,  Shuran XING

IPC: C12Q1/6832 ,  C12Q1/6869

Abstract: The present disclosure is directed to methods of using salivary exosomes to detect and treat Sjögren's syndrome in a subject.

公开(公告)号：US20210403881A1

公开(公告)日：2021-12-30

申请号：US17295287

申请日：2019-11-20

Applicant: Exosome Diagnostics, Inc.

Inventor： Georg STOLL ,  Daniel ENDERLE ,  Mikkel NOERHOLM ,  Johan Karl Olov SKOG

IPC: C12N7/00 ,  C12Q1/70 ,  C12N15/10

Abstract: The present disclosure provides compositions, methods and kits for internal controls of microvesicle isolations. The compositions, methods and kits can comprise enveloped viruses, including, but not limited to, inactive mouse hepatitis virus (MHV).

公开(公告)号：US20210388453A1

公开(公告)日：2021-12-16

申请号：US17411606

申请日：2021-08-25

Applicant: Exosome Diagnostics, Inc.

Inventor： Mikkel NOERHOLM ,  Susan BELZER ,  Charlotte ROMAIN ,  Johan Karl Olov SKOG ,  Leileata M. RUSSO ,  Wayne COMPER

IPC: C12Q1/6886 ,  C12N7/00

Abstract: The present invention features a method and kit for isolating microvesicles or extracting microvesicle nucleic acids from a biological sample by using a control particle. The present invention provides control particles that are viruses or virus-like particles, such as bacteriophages, that contain control nucleic acids that can be detected to assess the accuracy, reliability, and efficiency of the microvesicle isolation or nucleic acid extraction steps. The methods described herein may further comprise the analysis of the presence, absence, or level of at least one biomarker associated with a disease or medical condition for diagnosing, prognosing, or monitoring the disease or medical condition.

公开(公告)号：US20190284548A1

公开(公告)日：2019-09-19

申请号：US16301176

申请日：2017-05-15

Applicant: Exosome Diagnostics, Inc.

Inventor： Georg STOLL ,  Daniel ENDERLE ,  Mikkel NOERHOLM ,  Johan Karl Olov SKOG

IPC: C12N15/10 ,  C12N15/11

Abstract: The invention provides novel methods and kits for fully automated high-throughput method for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles, novel methods and kits for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles that do not require the use of phenol or chloroform, and for extracting nucleic acids from the extracellular vesicles and/or from the biological samples.

公开(公告)号：US20190144941A1

公开(公告)日：2019-05-16

申请号：US16098500

申请日：2017-05-05

Applicant: Exosome Diagnostics, Inc. ,  The Brigham and Women's Hospital, Inc.

Inventor： Johan Karl Olov SKOG ,  Jamil AZZI

IPC: C12Q1/6876 ,  C12Q1/686

Abstract: The invention relates generally to the use of microvesicle RNA signatures for diagnosis, predicting, and/or to monitor treatment efficacy, including patients who are candidates for renal transplant and/or who have received a renal transplant.”

公开(公告)号：US20210238582A1

公开(公告)日：2021-08-05

申请号：US17074040

申请日：2020-10-19

Applicant: Exosome Diagnostics, Inc.

Inventor： Georg STOLL ,  Daniel ENDERLE ,  Mikkel NOERHOLM ,  Johan Karl Olov SKOG

IPC: C12N15/10 ,  C12N15/11

Abstract: The invention provides novel methods and kits for fully automated high-throughput method for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles, novel methods and kits for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles that do not require the use of phenol or chloroform, and for extracting nucleic acids from the extracellular vesicles and/or from the biological samples.