公开(公告)号：US20130345561A1

公开(公告)日：2013-12-26

申请号：US13877257

申请日：2011-10-03

申请人： Fergus Quigley

发明人： Fergus Quigley

IPC分类号： A61M31/00

CPC分类号： A61M25/00 ,  A61B1/2676 ,  A61B90/39 ,  A61B2017/00867 ,  A61B2034/2051 ,  A61B2090/3987 ,  A61B2090/3991 ,  A61M25/0105 ,  A61M25/0108 ,  A61M25/09 ,  A61M31/005 ,  A61M2025/09166 ,  A61N5/1049

摘要： Systems and methods for treating a lung of a patient. One embodiment of a method comprises positioning a leadless marker in the lung of the patient relative to the target, and collecting position data of the marker. This method further comprises determining the location of the marker in an external reference frame outside of the patient based on the collected position data, and providing an objective output in the external reference frame that is responsive to movement of the marker. The objective output is provided at a frequency (i.e., periodicity) that results in a clinically acceptable tracking error. In addition, the objective output can also be provided at least substantially contemporaneously with collecting the position data used to determine the location of the marker.

摘要翻译： 用于治疗患者肺部的系统和方法。 一种方法的一个实施例包括将无引线标记物相对于靶标定位在患者的肺中，以及收集标记物的位置数据。 该方法还包括基于所收集的位置数据确定标记在患者外部的外部参考框架中的位置，以及响应于标记的移动而在外部参考框架中提供客观输出。 以导致临床上可接受的跟踪误差的频率（即，周期性）提供目标输出。 此外，目标输出还可以至少基本同时提供，收集用于确定标记位置的位置数据。

公开(公告)号：US08025693B2

公开(公告)日：2011-09-27

申请号：US11365325

申请日：2006-03-01

申请人： Fergus Quigley

发明人： Fergus Quigley

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2250/0028 ,  A61F2250/0029

摘要： A stent-graft or prosthesis (10) with enhanced flexibility, in particular enhanced bending flexibility, includes a radially distensible stent (24) and at least one continuously uninterrupted ePTFE tubular graft or covering (18) having a node and fibril structure. The tubular stent (24) includes opposed open ends (12′, 14′) and a stent wall structure (26) having opposed exterior (28) and luminal surfaces (30). The ePTFE covering (18) is securably disposed to at least one of the stent surfaces (28, 30). The ePTFE graft or covering (18) includes a tubular wall (16) that is continuously uninterrupted and desirably substantially free of slits, apertures and folds. The ePTFE graft (18) further includes a first region (20) and a second region (22), where the first region (20) has a different bending flexibility from the second region (22).

摘要翻译： 具有增强的柔性，特别是增强的弯曲柔性的支架移植物或假体（10）包括径向扩张的支架（24）和至少一个具有节点和原纤结构的连续不间断的ePTFE管状移植物或覆盖物（18）。 管状支架（24）包括相对的开放端（12'，14'）和具有相对的外部（28）和腔表面（30）的支架壁结构（26）。 ePTFE覆盖物（18）被牢固地设置在至少一个支架表面（28,30）上。 ePTFE移植物或覆盖物（18）包括连续不间断且期望地基本上没有狭缝，孔和折叠的管状壁（16）。 ePTFE移植物（18）还包括第一区域（20）和第二区域（22），其中第一区域（20）具有与第二区域（22）不同的弯曲柔性。

公开(公告)号：US07641681B2

公开(公告)日：2010-01-05

申请号：US11025826

申请日：2004-12-28

申请人： John Sherry ,  Fergus Quigley

发明人： John Sherry ,  Fergus Quigley

IPC分类号： A61F2/06

CPC分类号： A61F2/86 ,  A61F2002/075 ,  A61F2210/0076 ,  A61F2230/0054

摘要： A low profile, implantable prosthesis includes (a) a tubular graft including opposed open ends and having yarns in a textile pattern to define a textile wall having a luminal surface and an exterior surface; and (b) a tubular, radially extensible member including a portion arranged in a closed zig-zag pattern, the pattern having a series of angled bends at proximal and distal ends thereof, and longitudinally extending members having opposed proximal and distal ends, the distal ends being disposed from the angled bends of the proximal end; the longitudinally extending members having a plurality of detents for securing the yarns within the textile pattern at one of the opposed open ends, wherein the yarns of the textile patterns are securably disposed to the detents. The detents may be holes, inwardly extending notches, outwardly extending protuberances, or combinations thereof in the longitudinally extending members. The textile pattern of the graft may be a braided textile pattern, a woven textile pattern, a knitted textile pattern, and combinations thereof. Desirably, the zigzag portion of the radially extensible member is disposed beyond the open end of the graft. The radially extensible member may be a stent or may be an anchoring device for securing the prosthesis against the wall of a bodily lumen.

摘要翻译： 低度可植入的假体包括（a）管状移植物，其包括相对的开放端并且具有织物图案中的纱线以限定具有腔表面和外表面的织物壁; 和（b）管状的可径向延伸的构件，其包括以闭合的之字形图案布置的部分，所述图案在其近端和远端具有一系列成角度的弯曲部，以及具有相对的近端和远端的纵向延伸构件， 端部从近端的成角度的弯曲部设置; 纵向延伸部件具有多个棘爪，用于将织物图案中的纱线固定在相对的开口端中的一个处，其中织物图案的纱线牢固地设置在棘爪上。 棘爪可以是纵向延伸的构件中的孔，向内延伸的凹口，向外延伸的突起或其组合。 移植物的纺织图案可以是编织织物图案，纺织织物图案，针织织物图案及其组合。 期望地，可径向延伸的构件的锯齿形部分设置在移植物的开口端之外。 可径向延伸的构件可以是支架，也可以是用于将假体固定在体腔壁上的锚定装置。

公开(公告)号：US09943704B1

公开(公告)日：2018-04-17

申请号：US12563084

申请日：2009-09-18

申请人： Timothy P. Mate ,  Tricia V. Zeller ,  Steven C. Dimmer ,  Fergus Quigley

发明人： Timothy P. Mate ,  Tricia V. Zeller ,  Steven C. Dimmer ,  Fergus Quigley

IPC分类号： A61N5/00 ,  A61N5/10 ,  A61B90/10 ,  A61B90/00 ,  A61B34/20

CPC分类号： A61N5/1049 ,  A61B34/20 ,  A61B90/39 ,  A61B2034/2051 ,  A61B2090/101 ,  A61B2090/3908 ,  A61B2090/3958 ,  A61B2090/3975 ,  A61B2090/3987 ,  A61N5/1014 ,  A61N2005/1051

摘要： Method and system fiducials contained in removable a device for use in guided radiation therapy treatment. One embodiment includes an active marker configured to be pre-loaded into a catheter for removeably implanting in the tissue of a patient. Another embodiment of the implantable device includes a stability element coupled to the marker and further coupled to an explant line. In some embodiments, the stability element is configured to hold the marker at a fixed location within the catheter (e.g., known location) with respect to a target in the tissue. In other embodiments, the explant line has a first portion coupled to the marker and/or the stability element and a second portion configured to be at least proximate to the dermis of the patient.

公开(公告)号：US09545506B2

公开(公告)日：2017-01-17

申请号：US13877257

申请日：2011-10-03

申请人： Fergus Quigley

发明人： Fergus Quigley

IPC分类号： A61M25/00 ,  A61M31/00 ,  A61N5/10 ,  A61M5/00 ,  A61B17/00

CPC分类号： A61M25/00 ,  A61B1/2676 ,  A61B90/39 ,  A61B2017/00867 ,  A61B2034/2051 ,  A61B2090/3987 ,  A61B2090/3991 ,  A61M25/0105 ,  A61M25/0108 ,  A61M25/09 ,  A61M31/005 ,  A61M2025/09166 ,  A61N5/1049

摘要： Systems and methods for treating a lung of a patient. One embodiment of a method comprises positioning a leadless marker in the lung of the patient relative to the target, and collecting position data of the marker. This method further comprises determining the location of the marker in an external reference frame outside of the patient based on the collected position data, and providing an objective output in the external reference frame that is responsive to movement of the marker. The objective output is provided at a frequency (i.e., periodicity) that results in a clinically acceptable tracking error. In addition, the objective output can also be provided at least substantially contemporaneously with collecting the position data used to determine the location of the marker.

摘要翻译： 用于治疗患者肺部的系统和方法。 一种方法的一个实施例包括将无引线标记物相对于靶标定位在患者的肺中，以及收集标记物的位置数据。 该方法还包括基于所收集的位置数据确定标记在患者外部的外部参考框架中的位置，以及响应于标记的移动而在外部参考框架中提供客观输出。 以导致临床上可接受的跟踪误差的频率（即，周期性）提供目标输出。 此外，目标输出还可以至少基本同时提供，收集用于确定标记位置的位置数据。

公开(公告)号：US20070208409A1

公开(公告)日：2007-09-06

申请号：US11365324

申请日：2006-03-01

申请人： Fergus Quigley

发明人： Fergus Quigley

IPC分类号： A61F2/88

CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/072 ,  A61F2002/075

摘要： An implantable stent-graft (10) includes a radially distensible, tubular stent (20) having opposed open ends (12′, 14′) and a stent wall structure (16′) having opposed exterior and luminal surfaces (30, 32); and a segmented, non-textile polymeric tubular structure (16) including a plurality of graft segments (18) circumferentially disposed about one of the stent surfaces (30, 32), the graft segments (18) including first portions (24) securably disposed to the one the stent surfaces (30, 32) and second portions (26) not securably disposed to the one the stent surfaces (30, 32); wherein adjacent graft segments (18) are disposed over one and the other to define overlaps (26′), the overlaps (26′) forming a fluid tight seal when implanted in a body lumen.

摘要翻译： 可植入支架移植物（10）包括具有相对的开放端（12'，14'）和具有相对的外部和管腔表面（30,32）的支架壁结构（16'）的径向扩张的管状支架（20）。 以及分段的非纺织聚合物管状结构（16），其包括围绕其中一个支架表面（30,32）周向设置的多个移植物段（18），所述移植物区段（18）包括第一部分（24），其可固定地设置 支架表面（30,32）和第二部分（26）不固定地设置在支架表面（30,32）上的一个; 其中邻近的移植物段（18）被设置成一个并且另一个以限定重叠（26'），当植入体腔时，所述重叠物（26'）形成流体密封的密封。

公开(公告)号：US20070198079A1

公开(公告)日：2007-08-23

申请号：US11657140

申请日：2007-01-24

申请人： Thomas Casey ,  Kristoff Nelson ,  Fergus Quigley

发明人： Thomas Casey ,  Kristoff Nelson ,  Fergus Quigley

IPC分类号： A61F2/06 ,  A61F2/82

CPC分类号： A61F2/07 ,  A61F2/06 ,  A61F2/89

摘要： The present invention provides a sectional crimped graft that allows graft flexibility where required and limits the overall longitudinal extension. The present invention overcomes the disadvantage of fully crimped grafts by controlling the number of crimps per unit length, crimp height, crimp geometry and their location along the graft wall, dependent on the particular end-use application. In so doing, flexibility and elongation can be controllably tailored only in areas where significant anatomical angulation is present. It may also be useful in applications other than stent grafts such as surgical grafts for aortic and peripheral areas. Limiting the overall graft longitudinal extension also facilitates the deployment of the stent-graft into the blood vessel.

摘要翻译： 本发明提供了一种在需要时允许移植物柔性并限制整个纵向延伸的截面卷曲移植物。 根据特定的最终用途，本发明通过控制每单位长度的卷曲数量，卷曲高度，卷曲几何形状及其沿着移植物壁的位置克服了完全卷曲移植物的缺点。 在这样做时，灵活性和伸长率可以仅在存在显着解剖角度的区域中被可控地定制。 它也可用于除支架移植物以外的应用，例如用于主动脉和外周区域的手术移植物。 限制整个移植物纵向延伸也有助于将支架移植物部署到血管中。