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公开(公告)号：US20070190634A1
公开(公告)日：2007-08-16
申请号：US11786150
申请日：2007-04-11
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC分类号： C02F3/34
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US08669081B2
公开(公告)日：2014-03-11
申请号：US11786150
申请日：2007-04-11
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M.C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M.C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US07091343B2
公开(公告)日：2006-08-15
申请号：US10389296
申请日：2003-03-14
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC分类号： C07D403/12 , C07D409/14 , C07D417/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US07179826B2
公开(公告)日：2007-02-20
申请号：US10389709
申请日：2003-03-14
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC分类号： A01N43/78 , C07D271/02 , C07D253/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US08461149B2
公开(公告)日：2013-06-11
申请号：US12673287
申请日：2008-08-15
IPC分类号： C07D487/04 , A61K31/551
CPC分类号： C07D487/04 , A61K31/519 , A61K31/551 , A61K45/06 , C07D475/00 , C07D487/10 , C07D487/14
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20110263575A1
公开(公告)日：2011-10-27
申请号：US12673287
申请日：2008-08-15
IPC分类号： A61K31/551 , C07D475/00 , A61K31/519 , A61P35/00 , A61P25/28 , A61P37/00 , A61P29/00 , A61P37/02 , A61P35/02 , A61P37/06 , A61P25/00 , A61P9/00 , A61P19/08 , A61P1/16 , A61P31/12 , A61P7/00 , A61P3/10 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519 , A61K31/551 , A61K45/06 , C07D475/00 , C07D487/10 , C07D487/14
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US06727251B2
公开(公告)日：2004-04-27
申请号：US10034019
申请日：2001-12-20
IPC分类号： A61K3153
CPC分类号： C07D403/14 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D473/16 , C07D487/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04
摘要： This invention describes novel pyrazole compounds of formula II: wherein Z1 is nitrogen or CR8; Q is —S—, —O—, —N(R4)—, or —CH(R6)—; R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and Ry, R2, and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
摘要翻译： 本发明描述了式II的新型吡唑化合物：其中Z 1是氮或CR 8; Q是-S-，-O-，-N（R 4） - 或-CH（R 6） - ; R 1是T环D，其中环D是5-7元单环或选自芳基，杂芳基，杂环基或碳环基的8-10元双环; 和R y，R 2和R 2'如说明书中所述。 这些化合物可用作蛋白激酶抑制剂，特别是作为Aurora-2和GSK-3的抑制剂用于治疗诸如癌症，糖尿病和阿尔茨海默病的疾病。
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公开(公告)号：US20130096128A1
公开(公告)日：2013-04-18
申请号：US13631488
申请日：2012-09-28
IPC分类号： C07D403/14 , C07D409/14 , C07D417/14 , C07D403/12 , C07D401/14
CPC分类号： C07D403/14 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D473/16 , C07D487/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04
摘要： This invention describes novel pyrazole compounds of formula III: wherein Z1, Z2, and Z3 are as described in the specification; Q is —S—, —O—, —N(R4)—, or —CH(R6)—; R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and R2 and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
摘要翻译： 本发明描述了式III的新型吡唑化合物：其中Z1，Z2和Z3如说明书所述; Q是-S - ， - O - ， - N（R4） - 或-CH（R6） - ; R1是T环D，其中环D是5-7元单环或选自芳基，杂芳基，杂环基或碳环基的8-10元双环; R2和R2'如说明书所述。 这些化合物可用作蛋白激酶抑制剂，特别是作为Aurora-2和GSK-3的抑制剂用于治疗诸如癌症，糖尿病和阿尔茨海默病的疾病。
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公开(公告)号：US20080287444A1
公开(公告)日：2008-11-20
申请号：US12109598
申请日：2008-04-25
IPC分类号： A61K31/53 , C07D251/12 , C07D239/24 , A61K31/506 , C07D253/065 , C07D237/06 , A61K31/501 , A61P35/00 , A61P3/10 , A61P25/00 , A61P9/00
CPC分类号： C07D403/14 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D473/16 , C07D487/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04
摘要： This invention describes novel pyrazole compounds of formula III: wherein Z1, Z2, and Z3 are as described in the specification; Q is —S—, —O—, —N(R4)—, or —CH(R6)—; R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and R2 and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
摘要翻译： 本发明描述了式III的新型吡唑化合物：其中Z 1，Z 2和Z 3如说明书所述; Q是-S-，-O-，-N（R 4） - 或-CH（R 6） - ; R 1是T环D，其中环D是5-7元单环或选自芳基，杂芳基，杂环基或碳环基的8-10元双环; 和R 2和R 2'如说明书中所述。 这些化合物可用作蛋白激酶抑制剂，特别是作为Aurora-2和GSK-3的抑制剂用于治疗诸如癌症，糖尿病和阿尔茨海默病的疾病。
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公开(公告)号：US20060122213A1
公开(公告)日：2006-06-08
申请号：US11170779
申请日：2005-06-29
申请人： Francoise Pierard , Juan-Miguel Jimenez , Ronald Knegtel , Guy Brenchley , Michael Mortimore , Francesca Mazzei
发明人： Francoise Pierard , Juan-Miguel Jimenez , Ronald Knegtel , Guy Brenchley , Michael Mortimore , Francesca Mazzei
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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