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11.发明授权19-Nor steroids having a thiocarbonated chain in position 11beta, their preparation process and the intermediates of this process, their use as medicaments and compositions 失效19-在位置11beta上具有硫代碳链的类固醇，其制备方法和该方法的中间体，它们作为药物和组合物的用途公开(公告)号：US06596885B2
公开(公告)日：2003-07-22
申请号：US09891433
申请日：2001-06-26
IPC分类号： C07J100
CPC分类号： C07J31/006 , C07J41/0005 , C07J41/0016 , C07J41/0083 , C07J43/003
摘要： Novel compounds having a formula selected from the group consisting of wherein the substituents are defined as in the specification which are intermediates for the production of vinyl compounds having a remarkable anti-estrogenic and anti-proliferative activity.
摘要翻译： 具有选自其中的取代基的式的新型化合物如说明书中所定义，其是制备具有显着的抗雌激素和抗增殖活性的乙烯基化合物的中间体。
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公开(公告)号：US06472382B2
公开(公告)日：2002-10-29
申请号：US09733377
申请日：2000-12-08
IPC分类号： A61K3158
CPC分类号： C07J41/0083
摘要： A subject of the invention is the compounds of formula (I): in which X is a halogen atom, D represents the remainder of an optionally substituted pentagonal or hexagonal ring and optionally carrying an unsaturation, R1, R2, R3, R4, Y and n are as defined in the description, their preparation process and intermediates, their use as medicaments and the compositions containing them.
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13.发明授权4- Halogenated steroids, preparation method and intermediates, application as medicines and pharmaceutical compositions containing same 有权4-卤代类固醇，制备方法和中间体，作为药物和含有它们的药物组合物的应用公开(公告)号：US06239121B1
公开(公告)日：2001-05-29
申请号：US09402705
申请日：1999-11-29
IPC分类号： A61K31585
CPC分类号： C07J41/0083
摘要： A subject of the invention is the compounds of formula (I): in which X is a halogen atom, D represents the remainder of an optionally substituted pentagonal or hexagonal ring and optionally carrying an unsaturation, R1, R2, R3, R4, Y and n are as defined in the description, their preparation process and intermediates, their use as medicaments and the compositions containing them.
摘要翻译： 本发明的主题是式（I）的化合物：其中X是卤素原子，D表示任选取代的五价或六价环的其余部分，并且任选地带有不饱和键，R 1，R 2，R 3，R 4，Y和 n如说明书中所定义，其制备方法和中间体，它们作为药物的用途以及含有它们的组合物。
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公开(公告)号：US5981516A
公开(公告)日：1999-11-09
申请号：US993848
申请日：1997-12-18
申请人： Yamina Bouali , Daniel Philibert , Francois Nique , Jean-Georges Teutsch , Patrick Van De Velde
发明人： Yamina Bouali , Daniel Philibert , Francois Nique , Jean-Georges Teutsch , Patrick Van De Velde
IPC分类号： A61K31/56 , A61K31/565 , A61K31/567 , A61K31/58 , A61K31/585 , A61P19/10 , A61P43/00 , C07J41/00
CPC分类号： A61K31/566 , A61K31/565 , A61K31/567 , A61K31/58 , A61K31/585
摘要： A method of treating cholesterol without estrogenic activity at the uterine level in women comprising administering to women an amount of a steroid of the formula ##STR1## wherein the substituents are defined as in the specification without estrogenic activity at the uterine level.
摘要翻译： 一种治疗妇女在子宫水平没有雌激素活性的胆固醇的方法，包括向妇女施用一定量的下式的类固醇，其中取代基如本说明书所述，而在子宫水平下没有雌激素活性。
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公开(公告)号：US5679788A
公开(公告)日：1997-10-21
申请号：US731561
申请日：1996-10-16
CPC分类号： C07J1/0059 , C07J41/0072 , C07J41/0083 , C07J43/003
摘要： Intermediate compounds of a formula selected from the group consisting of ##STR1## which are useful intermediates for the preparation of final products of the formula ##STR2## wherein the substituents are defined in the specification.
摘要翻译： 选自下列化学式的中间体化合物：其中取代基在说明书中定义，其为制备式（I）的最终产物的有用中间体。
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公开(公告)号：US06790971B1
公开(公告)日：2004-09-14
申请号：US08442957
申请日：1995-05-17
申请人： Andrè Claussner , Lucien Nedelec , Daniel Philibert , Patrick Van De Velde , François Nique , Jean-Georges Teutsch
发明人： Andrè Claussner , Lucien Nedelec , Daniel Philibert , Patrick Van De Velde , François Nique , Jean-Georges Teutsch
IPC分类号： C07J100
CPC分类号： C07J43/003 , C07J41/0077 , C07J41/0083 , C07J63/008
摘要： A 19-nor-steroid having a formula selected from the group consisting of wherein the A and B rings have a structure selected from the group consisting of having hormonal properties and their preparation and novel intermediates.
摘要翻译： 具有选自A和B环中的式的19-去甲基甾体具有选自具有激素性质及其制备和新型中间体的结构。
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公开(公告)号：US5556845A
公开(公告)日：1996-09-17
申请号：US445385
申请日：1995-05-19
IPC分类号： A61K31/56 , A61K31/565 , A61K31/57 , A61K31/575 , A61K31/58 , A61P1/00 , A61P3/04 , A61P3/08 , A61P3/10 , A61P5/00 , A61P5/26 , A61P5/28 , A61P5/30 , A61P5/32 , A61P5/38 , A61P5/42 , A61P5/44 , A61P5/46 , A61P9/10 , A61P9/12 , A61P15/00 , A61P15/04 , A61P15/08 , A61P17/00 , A61P19/10 , A61P25/20 , A61P35/00 , A61P37/04 , A61P43/00 , C07J1/00 , C07J31/00 , C07J41/00 , C07J43/00 , C07J75/00
CPC分类号： C07J41/0083 , C07J1/0059 , C07J41/0072 , C07J43/003
摘要： A compound of the formula ##STR1## wherein the substituents are as defined in the specification.
摘要翻译： 式I的化合物，其中取代基如说明书中所定义。
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公开(公告)号：US5525594A
公开(公告)日：1996-06-11
申请号：US340025
申请日：1994-11-14
IPC分类号： C07H13/06 , A61K31/70 , A61K31/7024 , A61K36/18 , A61P5/28 , A61P31/12 , A61P35/00 , C07H13/08 , C07H15/203 , A61K31/045
CPC分类号： C07H15/203 , A61K31/70
摘要： A method of treating hyperandrogenism in warm-blooded animals comprising administering to warm-blooded animals an antiandro genically effective amount of oenotheine B and a process for the preparation of oenotheine B.
摘要翻译： 一种在温血动物中治疗雄激素过多症的方法，包括向温血动物施用抗血药活性有效量的奥来诺B，以及用于制备欧内宁B的方法。
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公开(公告)号：US5683996A
公开(公告)日：1997-11-04
申请号：US335163
申请日：1994-11-07
IPC分类号： C07D513/04 , C07D519/00 , C07D417/12 , A61K31/54
CPC分类号： C07D513/04
摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## and R.sub.b --NH--, Ra is an organic radical, Ri and Rj are individually selected from the group consisting of hydrogen, aliphatic hydrocarbon, aromatic hydrocarbon and heterocycle or taken together with the nitrogen atom to which they are attached form an optionally substituted ring, Rb is selected from the group consisting of carbocyclic aryl and heterocyclic aryl, both optionally substituted, R.sub.1A is selected from the group consisting of ##STR3## and ##STR4## are individually selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, Z.sub.A is selected from the group consisting of a simple bond, --O-- and optionally oxidized sulfur, R.sub.3A is selected from the group donsisting of optionally substituted carbocyclic aryl and heterocyclic aryl, optionally substitute quaternary ammonium, acetyle, carbamoyl, alkoxycarbonyl, alkyl and haloalkyl of 1 to 4 carbon atoms, --CN and azido, R.sub.4 is selected from the group consisting of hydrogen and methoxy, A is selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, magnesium, --NH.sub.4, an organic amine and esterified carboxy or COOA is --COO.sup.--, n.sub.2 is an integer from 0 to 2 and their non-toxic, pharmaceutical acceptable acid addition salts having excellent antibiotic activity.
摘要翻译： 选自下列化合物的化合物：其中R选自由下列组成的组成的组分：其中R选自由下列组成的组：R a-NH-，R a是有机基团，R 1和R j分别选自 由氢，脂族烃，芳族烃和杂环组成的组或与它们所连接的氮原子一起形成任选取代的环，R b选自碳环芳基和杂环芳基，二者均为取代基，R 1A 选自
和 分别选自氢和1至4个碳原子的烷基，ZA选自简单的键，-O-和任选被氧化的 硫，R3A选自任选取代的碳环芳基和杂环芳基，任选地取代季铵，乙酰基，氨基甲酰基，烷氧基羰基，烷基和卤代 1至4个碳原子的烷基，-CN和叠氮基，R 4选自氢和甲氧基，A选自氢，碱金属，碱土金属，镁，-NH 4，有机胺 酯化的羧基或COOA为-COO + E，crc - + EE，n2为0〜2的整数，其无毒的药学上可接受的酸加成盐具有优异的抗生素活性。 -
公开(公告)号：US5556983A
公开(公告)日：1996-09-17
申请号：US388131
申请日：1995-02-13
IPC分类号： C07D233/72 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61P13/02 , A61P15/00 , A61P17/00 , A61P35/00 , C07D233/74 , C07D233/76 , C07D233/82 , C07D233/86 , C07D233/88 , C07D235/02 , C07D233/42 , C07D233/40
CPC分类号： C07D233/76 , C07D233/86 , C07D233/88 , C07D235/02
摘要： Novel phenyimidazolidines having the following formula ##STR1## wherein the substituents are as recited in the specification and their non-toxic, pharmaceutically acceptable acid addition salts having anti-androgenic activity.
摘要翻译： 具有下列结构式的新型苯基咪唑烷：其中取代基如说明书中所述及其无毒的，药学上可接受的具有抗雄激素活性的酸加成盐。
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