-
1.发明授权Steroids substituted at the 11-position, process for their preparation, their use as medicament and the pharmaceutical compositions containing them 有权在11位取代的类固醇，其制备方法，其用作药物和含有它们的药物组合物公开(公告)号：US06541464B2
公开(公告)日：2003-04-01
申请号：US10075364
申请日：2002-02-14
IPC分类号： A61K3158
CPC分类号： C07J41/0083
摘要： Compounds of the formula Where the substituents are defined in the application.
摘要翻译： 取代基在本申请中定义的式的化合物。
-
公开(公告)号：US06462211B1
公开(公告)日：2002-10-08
申请号：US09746245
申请日：2000-12-22
IPC分类号： C07J100
CPC分类号： C07J41/0083
摘要： A subject of the invention is the compounds of formula (I): in which X is a halogen atom, D represents the remainder of an optionally substituted pentagonal or hexagonal ring and optionally carrying an unsaturation, R1, R2, R3, R4, Y and n are as defined in the description, their preparation process and intermediates, their use as medicaments and the compositions containing them.
-
公开(公告)号：US5494907A
公开(公告)日：1996-02-27
申请号：US246190
申请日：1994-05-19
IPC分类号： A61K31/56 , A61K31/565 , A61K31/57 , A61K31/575 , A61K31/58 , A61P1/00 , A61P3/04 , A61P3/08 , A61P3/10 , A61P5/00 , A61P5/26 , A61P5/28 , A61P5/30 , A61P5/32 , A61P5/38 , A61P5/42 , A61P5/44 , A61P5/46 , A61P9/10 , A61P9/12 , A61P15/00 , A61P15/04 , A61P15/08 , A61P17/00 , A61P19/10 , A61P25/20 , A61P35/00 , A61P37/04 , A61P43/00 , C07J1/00 , C07J31/00 , C07J41/00 , C07J43/00 , C07J75/00
CPC分类号： C07J41/0083 , C07J1/0059 , C07J41/0072 , C07J43/003
摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the specification having anti-estrogen activity.
摘要翻译： 选自由下式的化合物组成的组的化合物，其中取代基如具有抗雌激素活性的说明书所定义。
-
公开(公告)号：US5290771A
公开(公告)日：1994-03-01
申请号：US875460
申请日：1992-04-29
CPC分类号： C07J41/0083 , C07J41/0077 , C07J43/003
摘要： The novel compounds of the invention are 19 nor-steroids of the formula: ##STR1## Where A, B, C, D, X, Y, Z, R.sub.17, and R.sup.1 are as defined in the specification, having hormonal properties and their preparation and intermediates.
摘要翻译： 本发明的新化合物是下式的19种类固醇：其中A，B，C，D，X，Y，Z，R 17和R 1如说明书中所定义，具有激素性质及其 制剂和中间体。
-
公开(公告)号：US06790971B1
公开(公告)日：2004-09-14
申请号：US08442957
申请日：1995-05-17
申请人： Andrè Claussner , Lucien Nedelec , Daniel Philibert , Patrick Van De Velde , François Nique , Jean-Georges Teutsch
发明人： Andrè Claussner , Lucien Nedelec , Daniel Philibert , Patrick Van De Velde , François Nique , Jean-Georges Teutsch
IPC分类号： C07J100
CPC分类号： C07J43/003 , C07J41/0077 , C07J41/0083 , C07J63/008
摘要： A 19-nor-steroid having a formula selected from the group consisting of wherein the A and B rings have a structure selected from the group consisting of having hormonal properties and their preparation and novel intermediates.
摘要翻译： 具有选自A和B环中的式的19-去甲基甾体具有选自具有激素性质及其制备和新型中间体的结构。
-
6.发明授权Steroids substituted at the 11-position, process for their preparation, their use as medicament and the pharmaceutical compositions containing them 有权在11位取代的类固醇，其制备方法，其用作药物和含有它们的药物组合物公开(公告)号：US06482813B1
公开(公告)日：2002-11-19
申请号：US09592710
申请日：2000-06-13
IPC分类号： A61K31585
CPC分类号： C07J41/0083
摘要： Compounds of formula for treating osteoporosis with minimal estrogenic activity are disclosed.
摘要翻译： 公开了治疗具有最小雌激素活性的骨质疏松症的配方的化合物。
-
7.发明授权Steroids substituted in position 11, method of preparation, application as medicines and pharmaceutical compositions containing them 有权在11位取代的类固醇，制备方法，作为药物的应用和含有它们的药物组合物公开(公告)号：US06207657B1
公开(公告)日：2001-03-27
申请号：US09331823
申请日：1999-10-04
IPC分类号： A61K31565
CPC分类号： C07J41/0083
摘要： The invention concerns steroid compounds of general formula (I) in which n=2, 3, either R1 and R2═H, (C1-C4) alkyl, or R1 and R2 form with nitrogen a heterocyclic compound, X═OH optionally esterified, Y═(C1-C4)alkyl, and their additive salts, the method for preparing them, their application as medicine and the pharmaceutical compositions containing them.
摘要翻译： 本发明涉及通式（I）的类固醇化合物，其中n = 2,3，R 1和R 2 = H，（C 1 -C 4）烷基，或R 1和R 2与氮形成杂环化合物，X = OH任选酯化， Y =（C1-C4）烷基及其添加盐，其制备方法，作为药物的应用和含有它们的药物组合物。
-
公开(公告)号：US6011026A
公开(公告)日：2000-01-04
申请号：US249416
申请日：1999-02-12
申请人： Yamina Bouali , Daniel Philibert , Francois Nique , Jean-Georges Teutsch , Patrick Van De Velde
发明人： Yamina Bouali , Daniel Philibert , Francois Nique , Jean-Georges Teutsch , Patrick Van De Velde
IPC分类号： A61K31/56 , A61K31/565 , A61K31/567 , A61K31/58 , A61K31/585 , A61P19/10 , A61P43/00 , C07J41/00
CPC分类号： A61K31/566 , A61K31/565 , A61K31/567 , A61K31/58 , A61K31/585
摘要： A method of treating menopause or perimenopause without estrogenic activity at the uterine level in women comprising administering to women an amount of a steroid of the formula ##STR1## wherein the substituents are defined as in the specification sufficient to treat menopause or perimenopause symptoms without estrogenic activity at the uterine level.
摘要翻译： 一种在妇女中治疗绝经期或围绝经期而不具有子宫水平的雌激素活性的方法，包括向妇女施用一定量的下式的类固醇，其中取代基如本说明书中所定义足以治疗子宫内无雌激素活性的绝经期或围绝经期症状 水平。
-
公开(公告)号：US5556845A
公开(公告)日：1996-09-17
申请号：US445385
申请日：1995-05-19
IPC分类号： A61K31/56 , A61K31/565 , A61K31/57 , A61K31/575 , A61K31/58 , A61P1/00 , A61P3/04 , A61P3/08 , A61P3/10 , A61P5/00 , A61P5/26 , A61P5/28 , A61P5/30 , A61P5/32 , A61P5/38 , A61P5/42 , A61P5/44 , A61P5/46 , A61P9/10 , A61P9/12 , A61P15/00 , A61P15/04 , A61P15/08 , A61P17/00 , A61P19/10 , A61P25/20 , A61P35/00 , A61P37/04 , A61P43/00 , C07J1/00 , C07J31/00 , C07J41/00 , C07J43/00 , C07J75/00
CPC分类号： C07J41/0083 , C07J1/0059 , C07J41/0072 , C07J43/003
摘要： A compound of the formula ##STR1## wherein the substituents are as defined in the specification.
摘要翻译： 式I的化合物，其中取代基如说明书中所定义。
-
10.发明授权17-halogenated 19-nor steroids, method and intermediates for preparing same, use as medicines and pharmaceutical compositions containing same 有权17-卤化的19-或类固醇，其制备方法和中间体，用作药物和含有它们的药物组合物公开(公告)号：US06423700B1
公开(公告)日：2002-07-23
申请号：US09720565
申请日：2001-01-05
IPC分类号： A61K3158
CPC分类号： C07J41/0083
摘要： A compound of the formula wherein the substituents are as defined in the application and its non-toxic, pharmaceutically acceptable acid and base salts useful for hormone replacement for treating menopause or perimenopause without activity at the uterine level treating osteoporosis and strengthening cardiovascular protection in warm-blooded animals.
摘要翻译： 取代基中的取代基的化合物如本申请中所定义，并且其无毒的药学上可接受的酸和碱盐可用于激素替代以治疗绝经或围绝经期，而在子宫水平治疗骨质疏松症和加强温血血管内的心血管保护 动物。
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.032 秒)
