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公开(公告)号：US20120135920A1
公开(公告)日：2012-05-31
申请号：US13309134
申请日：2011-12-01
申请人： Helle Birk Olsen , Svend Havelund , Ulla Ribel-Madsen , Jeppe Sturis , Helle Naver , Morten Schlein , Svend Ludvigsen
发明人： Helle Birk Olsen , Svend Havelund , Ulla Ribel-Madsen , Jeppe Sturis , Helle Naver , Morten Schlein , Svend Ludvigsen
CPC分类号： A61K38/28 , A61K9/0019 , A61K31/198 , A61K31/455 , A61K31/465 , A61K45/06 , A61K47/02 , A61K47/183 , A61K47/22 , A61K2300/00
摘要： Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.
摘要翻译： 包含胰岛素化合物或两种或更多种胰岛素化合物，烟碱化合物和氨基酸的混合物的胰岛素制剂。
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12.发明申请公开(公告)号：US20080280814A1
公开(公告)日：2008-11-13
申请号：US11663111
申请日：2005-09-19
申请人： Svend Ludvigsen , Morten Schlein
发明人： Svend Ludvigsen , Morten Schlein
CPC分类号： A61K38/28
摘要： Pharmaceutical composition for parenteral administration comprising insulin peptide an insulinotropic peptide and a ligand for the Hisb10 anion site.
摘要翻译： 用于肠胃外给药的药物组合物，其包含胰岛素肽，促胰岛素肽和His B10阴离子位点的配体。
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公开(公告)号：US20060258561A1
公开(公告)日：2006-11-16
申请号：US11226870
申请日：2005-09-09
申请人： Per Balschmidt , Helle Olsen , Niels Kaarsholm , Peter Madsen , Palle Jakobsen , Svend Ludvigsen , Gerd Schluckebier , Dorte Steensgaard , Anders Petersen
发明人： Per Balschmidt , Helle Olsen , Niels Kaarsholm , Peter Madsen , Palle Jakobsen , Svend Ludvigsen , Gerd Schluckebier , Dorte Steensgaard , Anders Petersen
IPC分类号： A61K38/28 , A61K31/522 , A61K31/513 , A61K31/426 , A61K31/4196 , A61K31/4184 , A61K31/4166 , A61K33/32
CPC分类号： A61K31/4166 , A61K31/4184 , A61K31/4196 , A61K31/426 , A61K31/513 , A61K31/522 , A61K33/30 , A61K38/28 , A61K45/06
摘要： This invention relates to NPH-insulin (crystalline preparations) that are prepared in the presence of certain high-affinity ligands for the HisB10 Zn2+-sites of the R-state insulin hexamer. Preparation of NPH-insulin in the presence of high-affinity ligand results in crystalline NPH-insulin suspensions that are absorbed more slowly from subcutis than regular NPH-insulin. Hence the resulting action profile is longer and the spike is less pronounced than observed with regular NPH-insulin
摘要翻译： 本发明涉及在R状态胰岛素六聚体的HisB10 Zn 2+ 2+的某些高亲和力配体存在下制备的NPH-胰岛素（结晶制剂）。 在高亲和力配体的存在下制备NPH-胰岛素导致结晶NPH-胰岛素悬浮液比皮下组织比常规NPH-胰岛素更慢吸收。 因此，所得到的作用谱更长，并且峰值不如用常规NPH-胰岛素观察到的
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公开(公告)号：US07087408B2
公开(公告)日：2006-08-08
申请号：US10316421
申请日：2002-12-11
CPC分类号： C07K14/62
摘要： Novel insulin precursors and insulin precursor analogs having a mini C-peptide comprising at least one aromatic amino acid residue have an increased folding stability. The novel insulin precursors and insulin precursor analogs can be expressed in yeast in high yields and are preferably not more 15 amino acid residues in length. Also provided are polynucleotide sequences encoding the claimed precursors or precursor analogs, and vectors and cell lines containing such polynucleotide sequences.
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公开(公告)号：US20100173844A1
公开(公告)日：2010-07-08
申请号：US12643330
申请日：2009-12-21
申请人： Svend Ludvigsen , Morten Schlein , Tine Elisabeth Gottschalk Boving , Claude Bonde , Anne-Mette Lilleore , Dorthe Kot Engelund , Bjarne Ronfeldt Nielsen
发明人： Svend Ludvigsen , Morten Schlein , Tine Elisabeth Gottschalk Boving , Claude Bonde , Anne-Mette Lilleore , Dorthe Kot Engelund , Bjarne Ronfeldt Nielsen
CPC分类号： A61K47/26 , A61K9/0019 , A61K38/26 , A61K47/10
摘要： Stable pharmaceutical composition comprising insulinotropic peptide.
摘要翻译： 包含促胰岛素肽的稳定的药物组合物。
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公开(公告)号：US08748376B2
公开(公告)日：2014-06-10
申请号：US12643330
申请日：2009-12-21
申请人： Svend Ludvigsen , Morten Schlein , Tine Elisabeth Gottschalk Bøving , Claude Bonde , Anne-Mette Lilleøre , Dorthe Kot Engelund , Bjarne Rønfeldt Nielsen
发明人： Svend Ludvigsen , Morten Schlein , Tine Elisabeth Gottschalk Bøving , Claude Bonde , Anne-Mette Lilleøre , Dorthe Kot Engelund , Bjarne Rønfeldt Nielsen
IPC分类号： A61K38/26 , C07K14/605
CPC分类号： A61K47/26 , A61K9/0019 , A61K38/26 , A61K47/10
摘要： Stable pharmaceutical composition comprising insulinotropic peptide.
摘要翻译： 包含促胰岛素肽的稳定的药物组合物。
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17.发明授权Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast 有权制备酵母中发酵产量提高的胰岛素前体和胰岛素前体类似物的方法公开(公告)号：US08129146B2
公开(公告)日：2012-03-06
申请号：US12104809
申请日：2008-04-17
IPC分类号： C12N15/17
CPC分类号： C07K14/62
摘要： Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance between B27 (atom CG2) and A1 (atom CA) of less than 5 Å.
摘要翻译： 提供了包含优选至多15个氨基酸残基并且包含至少一个Gly的连接肽（小C肽）的新型胰岛素前体和胰岛素前体类似物。 前体可转化为人胰岛素或人胰岛素类似物。 前体通常具有小于5埃的B27（原子CG2）和A1（原子CA）之间的距离。
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18.发明授权Ligands for the HisB10 Zn2 + sites of the R-state insulin hexamer 有权用于R-state胰岛素六聚体的HisB10 Zn2 +位点的配体公开(公告)号：US07879893B2
公开(公告)日：2011-02-01
申请号：US10332541
申请日：2002-09-13
申请人： Helle Birk Olsen , Niels C. Kaarsholm , Peter Madsen , Soren Ostergaard , Svend Ludvigsen , Palle Jakobsen , Anders Klarskov Petersen , Dorte Bjerre Steensgaard
发明人： Helle Birk Olsen , Niels C. Kaarsholm , Peter Madsen , Soren Ostergaard , Svend Ludvigsen , Palle Jakobsen , Anders Klarskov Petersen , Dorte Bjerre Steensgaard
IPC分类号： A61K31/41 , A61K31/40 , C07D257/00 , C07D209/82
CPC分类号： C07D257/04 , A61K31/4192 , A61K31/426 , C07D249/18 , C07D277/20 , C07D403/04 , C07D417/06 , C07D417/10 , C07D417/14 , C07D471/04
摘要： The present invention relates to novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer having the formula A-B-C-D-X (III), wherein: A is a chemical group which reversibly binds to a HisB10 Zn2+ sites of an insulin hexamer; B is a linker; C is a fragment consisting of 0 to 5 neutral amino acids; D is a fragment comprising 1 to 20 positively charged groups independently selected from amino or guanidino groups; and X is —OH, —NH2 or a diamino group. The present invention also relates to R-state insulin hexamers comprising such ligands, and aqueous insulin preparations comprising such R-state insulin hexamers.
摘要翻译： 本发明涉及具有式A-B-C-D-X（III）的R状态胰岛素六聚体的HisB10 Zn 2+位点的新配体，其中：A是可逆结合胰岛素六聚体的HisB10 Zn 2+位点的化学基团; B是一个连接子; C是由0至5个中性氨基酸组成的片段; D是包含1至20个独立地选自氨基或胍基的带正电基团的片段; X为-OH，-NH 2或二氨基。 本发明还涉及包含这种配体的R状态胰岛素六聚体和包含这种R状态胰岛素六聚体的含水胰岛素制剂。
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公开(公告)号：US06521738B2
公开(公告)日：2003-02-18
申请号：US09736611
申请日：2000-12-14
IPC分类号： C07K1462
CPC分类号： C07K14/62
摘要： Novel insulin precursors and insulin precursor analogs having a mini C-peptide comprising at least one aromatic amino acid residue have an increased folding stability. The novel insulin precursors and insulin precursor analogs can be expressed in yeast in high yields and are preferably not more 15 amino acid residues in length. Also provided are polynucleotide sequences encoding the claimed precursors or precursor analogs, and vectors and cell lines containing such polynucleotide sequences.
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公开(公告)号：US08324157B2
公开(公告)日：2012-12-04
申请号：US13309134
申请日：2011-12-01
申请人： Helle Birk Olsen , Svend Havelund , Ulla Ribel-Madsen , Jeppe Sturis , Helle Naver , Morten Schlein , Svend Ludvigsen
发明人： Helle Birk Olsen , Svend Havelund , Ulla Ribel-Madsen , Jeppe Sturis , Helle Naver , Morten Schlein , Svend Ludvigsen
CPC分类号： A61K38/28 , A61K9/0019 , A61K31/198 , A61K31/455 , A61K31/465 , A61K45/06 , A61K47/02 , A61K47/183 , A61K47/22 , A61K2300/00
摘要： Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.
摘要翻译： 包含胰岛素化合物或两种或更多种胰岛素化合物，烟碱化合物和氨基酸的混合物的胰岛素制剂。
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