公开(公告)号：US07662147B2

公开(公告)日：2010-02-16

申请号：US12028687

申请日：2008-02-08

申请人： Ralf Kessler ,  Frieder Loesel ,  Thomas Sauter

发明人： Ralf Kessler ,  Frieder Loesel ,  Thomas Sauter

IPC分类号： A61F9/008

CPC分类号： G02B26/0816 ,  A61F9/0084 ,  A61F2009/00872

摘要： A device and method for steering a laser beam to a focal point in target tissue requires generating a laser beam. Diversions of the laser beam from a central beam path are minimized by a sequential arrangement of optical steering components. In order, the beam is first directed to the center of a z-scanning apparatus which will move the focal point in the medium in a z-direction. The beam is then passed to the center of a first galvanometric mirror which introduces focal point movements in the x-direction. A second galvanometric mirror then compensates for the x-direction movement by redirecting the beam to the center of a third galvanometric mirror where focal point movements in the y-direction are introduced.

摘要翻译： 用于将激光束转向目标组织中的焦点的装置和方法需要产生激光束。 通过光学转向部件的顺序布置，使来自中心光束路径的激光束的转移最小化。 按顺序，光束首先被引导到z扫描装置的中心，Z扫描装置将在z方向上移动介质中的焦点。 然后将光束传递到在x方向引入焦点运动的第一电流计镜的中心。 然后，第二电流计反射镜通过将光束重定向到引入在y方向上的焦点运动的第三电流计镜的中心来补偿x方向运动。

公开(公告)号：US07238176B2

公开(公告)日：2007-07-03

申请号：US10835087

申请日：2004-04-29

申请人： Frieder Loesel ,  Thomas Sauter

发明人： Frieder Loesel ,  Thomas Sauter

IPC分类号： A61B18/20

CPC分类号： A61F9/008 ,  A61F9/00836 ,  A61F2009/00872 ,  A61F2009/00897

摘要： A method is disclosed for photodisrupting a surface in the stroma of an eye at a substantially constant distance from the anterior surface of the eye. A frame of reference is established for the eye that includes an axis of rotation. Next, the focal point of a laser beam is positioned in the stroma at a radial distance from the axis. At least one laser pulse is delivered to the stromal tissue at the focal point, photodisrupting the tissue there and creating a photodisruption bubble having a diameter “d”. The focal point is then rotated about the axis through an arc length substantially equal to “d” and the photodisruption step is repeated. During rotation, the distance between the focal point and the axis is decreased at a rate substantially equal to the distance “d” per revolution. The method can be used to create a flap for a LASIK type procedure.

摘要翻译： 公开了一种用于以与眼睛的前表面基本上恒定的距离光学破坏眼睛基质表面的方法。 为包括旋转轴的眼睛建立了参考框架。 接下来，激光束的焦点位于离轴的径向距离的基质中。 至少一个激光脉冲被传送到焦点处的基质组织，对其中的组织进行光学破坏，并产生具有直径“d”的光致破裂气泡。 然后将焦点绕轴线旋转通过基本上等于“d”的弧长，并重复光致中断步骤。 在旋转期间，焦点和轴之间的距离以基本上等于每转的距离“d”的速率减小。 该方法可用于为LASIK型过程创建一个瓣。

公开(公告)号：US20050228366A1

公开(公告)日：2005-10-13

申请号：US10821402

申请日：2004-04-09

申请人： Ralf Kessler ,  Frieder Loesel ,  Thomas Sauter

发明人： Ralf Kessler ,  Frieder Loesel ,  Thomas Sauter

IPC分类号： A61B18/20 ,  A61F9/007 ,  A61F9/01 ,  G02B26/08

CPC分类号： G02B26/0816 ,  A61F9/0084 ,  A61F2009/00872

摘要： A device and method for steering a laser beam to a focal point in target tissue requires generating a laser beam. Diversions of the laser beam from a central beam path are minimized by a sequential arrangement of optical steering components. In order, the beam is first directed to the center of a z-scanning apparatus which will move the focal point in the medium in a z-direction. The beam is then passed to the center of a first galvanometric mirror which introduces focal point movements in the x-direction. A second galvanometric mirror then compensates for the x-direction movement by redirecting the beam to the center of a third galvanometric mirror where focal point movements in the y-direction are introduced.

摘要翻译： 用于将激光束转向目标组织中的焦点的装置和方法需要产生激光束。 通过光学转向部件的顺序布置，使来自中心光束路径的激光束的转移最小化。 按顺序，光束首先被引导到z扫描装置的中心，Z扫描装置将在z方向上移动介质中的焦点。 然后将光束传递到在x方向引入焦点运动的第一电流计镜的中心。 然后，第二电流计反射镜通过将光束重定向到引入在y方向上的焦点运动的第三电流计镜的中心来补偿x方向运动。

公开(公告)号：US20080147051A1

公开(公告)日：2008-06-19

申请号：US12028687

申请日：2008-02-08

申请人： Ralf Kessler ,  Frieder Loesel ,  Thomas Sauter

发明人： Ralf Kessler ,  Frieder Loesel ,  Thomas Sauter

IPC分类号： A61F9/01 ,  A61B18/22

CPC分类号： G02B26/0816 ,  A61F9/0084 ,  A61F2009/00872

摘要： A device and method for steering a laser beam to a focal point in target tissue requires generating a laser beam. Diversions of the laser beam from a central beam path are minimized by a sequential arrangement of optical steering components. In order, the beam is first directed to the center of a z-scanning apparatus which will move the focal point in the medium in a z-direction. The beam is then passed to the center of a first galvanometric mirror which introduces focal point movements in the x-direction. A second galvanometric mirror then compensates for the x-direction movement by redirecting the beam to the center of a third galvanometric mirror where focal point movements in the y-direction are introduced.

摘要翻译： 用于将激光束转向目标组织中的焦点的装置和方法需要产生激光束。 通过光学转向部件的顺序布置，使来自中心光束路径的激光束的转移最小化。 按顺序，光束首先被引导到z扫描装置的中心，Z扫描装置将在z方向上移动介质中的焦点。 然后将光束传递到在x方向引入焦点运动的第一电流计镜的中心。 然后，第二电流计反射镜通过将光束重定向到引入在y方向上的焦点运动的第三电流计镜的中心来补偿x方向运动。

公开(公告)号：US20100249761A1

公开(公告)日：2010-09-30

申请号：US12757798

申请日：2010-04-09

申请人： Luis Antonio Ruiz ,  Josef F. Bille ,  Frieder Loesel

发明人： Luis Antonio Ruiz ,  Josef F. Bille ,  Frieder Loesel

IPC分类号： A61B18/20

CPC分类号： A61F9/008 ,  A61F9/00827 ,  A61F9/00838 ,  A61F2009/00872 ,  A61F2009/00882 ,  A61F2009/00895 ,  A61F2009/00897

摘要： A system for changing the configuration of a transparent, resilient material, for the purpose of altering its optical properties, requires obtaining a topology for the material. The obtained data is then used to create a computer program for operating a laser unit. In accordance with the program, the laser unit creates incisions within a defined operational volume, inside the material, to weaken the material (i.e. change its internal stress distributions). Specifically, the incisions are made on predetermined surfaces (e.g. cylindrical surfaces) in the operational volume by Laser Induced Optical Breakdown (LIOB). As a consequence of the incisions, the material undergoes the desired configurational change in response to external forces applied on the material.

摘要翻译： 用于改变透明弹性材料的构造以改变其光学性质的系统需要获得材料的拓扑。 所获得的数据然后用于创建用于操作激光单元的计算机程序。 根据程序，激光单元在材料内部的限定的操作体积内产生切削以削弱材料（即改变其内部应力分布）。 具体地，通过激光诱导光学破坏（LIOB）在操作体积中的预定表面（例如圆柱形表面）上进行切口。 作为切口的结果，材料响应于施加在材料上的外力而经历期望的结构变化。

公开(公告)号：US07717905B2

公开(公告)日：2010-05-18

申请号：US10978613

申请日：2004-11-01

申请人： Frieder Loesel ,  Tobias Kuhn

发明人： Frieder Loesel ,  Tobias Kuhn

IPC分类号： A61F9/008

CPC分类号： A61F9/008 ,  A61F9/00825 ,  A61F2009/00872 ,  A61F2009/00897

摘要： A system and method for performing laser induced optical breakdown (LIOB) in corneal tissue of an eye requires calculating a pattern of focal spots. LIOB is then induced at a first focal spot, and is continued at a plurality of interim focal spots within a time period τ. Each focal spot has a diameter “d1” and generates a temporal cavitation bubble of diameter “d2”. It then collapses within time “τ” to a substantially stationary diameter “d3”, with (d1≦d3≦d2). Importantly, each focal spot is located more than “d2” from every other interim focal spot within the time period of “τ”. At the time “τ”, a second focal spot in the pattern can be generated at a distance “d3” from the first focal spot. This process is then continued with another plurality of interim focal spots being generated within another time period “τ”.

摘要翻译： 用于在眼睛的角膜组织中进行激光诱导光学击穿（LIOB）的系统和方法需要计算焦点的图案。 然后在第一焦点处诱导LIOB，并且在时间段τ内在多个临时焦斑处继续。 每个焦斑具有直径“d1”，并产生直径“d2”的时间空化气泡。 然后在时间“τ”内崩溃到基本上静止的直径“d3”，其中（d1＆nlE; d3＆nlE; d2）。 重要的是，在“τ”的时间段内，每个焦斑位于距离每个其他中间焦点的“d2”以上。 在时间“τ”，可以在与第一焦点相距“d3”的距离处产生图案中的第二焦点。 然后继续在另一个时间段“τ”内产生另外多个临时焦斑的过程。

公开(公告)号：US20090299346A1

公开(公告)日：2009-12-03

申请号：US12130937

申请日：2008-05-30

申请人： Josef F. Bille ,  Frieder Loesel

发明人： Josef F. Bille ,  Frieder Loesel

IPC分类号： A61B18/20

CPC分类号： A61F9/00804 ,  A61F9/008 ,  A61F9/00827 ,  A61F9/009 ,  A61F2009/00872

摘要： A system and method to compensate for the deformation of an eye requires calculation of an induced deformation angle Ψ, wherein the deformation is intentionally induced during laser surgery by a contact lens, and a refraction angle φ. Specifically, during laser surgery, the cornea of an eye is typically stabilized by a contact lens. This deforms the cornea. When the contact lens is removed after the surgery, the cornea recovers from the deformation. For the present invention, the angle Ψ is calculated, and corrected by the angle φ, so that surfaces altered during surgery (e.g. by LIOB) will become substantially parallel to incoming light in the eye, after the contact lens has been removed after surgery.

摘要翻译： 用于补偿眼睛变形的系统和方法需要计算诱导变形角Psi，其中在激光手术期间由隐形眼镜有意诱导变形和折射角phi。 具体地，在激光手术期间，眼睛的角膜通常由隐形眼镜稳定。 这会使角膜变形。 手术后移除隐形眼镜时，角膜会从变形中恢复。 对于本发明，计算角度Psi并通过角度phi进行校正，使得在手术后移除隐形眼镜后，手术期间改变的表面（例如通过LIOB）将变得基本上平行于眼睛中的入射光。

公开(公告)号：US20060106372A1

公开(公告)日：2006-05-18

申请号：US10987542

申请日：2004-11-12

申请人： Tobias Kuhn ,  Frieder Loesel

发明人： Tobias Kuhn ,  Frieder Loesel

IPC分类号： A61F9/008 ,  A61B18/18

CPC分类号： A61F9/008 ,  A61F9/00827 ,  A61F2009/00872 ,  A61F2009/00897

摘要： A method for photodisrupting a preselected subsurface volume of corneal tissue to alter a cornea's refractive properties is disclosed. Specifically, at least one stromal volume having a substantially conical shaped surface is photodisrupted. For this purpose, a laser device having a laser source, laser scanner and one or more optical elements is typically used. In one embodiment, a plurality of stromal volumes, with each stromal volume having a substantially conical shaped surface, is sequentially photodisrupted to form a contiguous stromal cavity. In a particular implementation, each conical shaped surface defines a cone axis that is aligned to be co-linear with a reference axis that passes through the anterior surface of the eye and may be aligned orthogonally to the anterior surface of the eye.

摘要翻译： 公开了一种用于光破坏预选的地下体积的角膜组织以改变角膜的折射性质的方法。 具体地说，具有基本圆锥形表面的至少一个基质体积被光破坏。 为此，通常使用具有激光源，激光扫描器和一个或多个光学元件的激光装置。 在一个实施方案中，具有每个基质体积具有基本上圆锥形表面的多个基质体积被顺序地光致破坏以形成连续的基质腔。 在特定实施方案中，每个圆锥形表面限定锥形轴线，该锥形轴线对齐以与穿过眼睛前表面的参考轴线共线，并且可以与眼睛的前表面正交对齐。

公开(公告)号：US06382797B1

公开(公告)日：2002-05-07

申请号：US09690776

申请日：2000-10-17

申请人： Josef Bille ,  Frieder Loesel

发明人： Josef Bille ,  Frieder Loesel

IPC分类号： A61B310

CPC分类号： A61B3/10

摘要： A device and method for establishing an aberration-free delivery system for use in evaluating an optical specimen includes a light source for directing light through the system and along a beam path toward the specimen. A first beam splitter is positioned on the beam path to direct light radiated from the system toward a detector for creation of a first wavefront, and for generation of a signal. In turn, the signal is used to program an active mirror that is also positioned on the beam path, to thereafter establish an aberration-free wavefront for light incident on the optical specimen. Further, a second beam splitter is positioned on the beam path for directing light reflected from the specimen toward the detector for the creation of a second wavefront having characteristics of optical aberrations in the specimen. The second wavefront is then used to further program the active mirror for analysis and evaluation of the optical specimen.

摘要翻译： 用于建立用于评估光学试样的无像差的传送系统的装置和方法包括用于引导光通过系统并沿着朝向样本的光束路径的光源。 第一分束器位于光束路径上以将从系统辐射的光引向检测器，以产生第一波前，并产生信号。 接着，该信号用于对同时位于光束路径上的有源反射镜进行编程，然后为入射在光学样本上的光线建立无像差波前。 此外，第二分束器位于光束路径上，用于将从样本反射的光引向检测器，以产生具有样品中的光学像差特征的第二波前。 然后，第二波前用于进一步编程主动镜，用于光学样本的分析和评估。

公开(公告)号：US06155684A

公开(公告)日：2000-12-05

申请号：US334774

申请日：1999-06-16

申请人： Josef Bille ,  Frieder Loesel

发明人： Josef Bille ,  Frieder Loesel

IPC分类号： A61B3/10 ,  A61B3/103 ,  A61B3/107

CPC分类号： A61B3/103

摘要： A system for precompensating the refractive properties of an eye includes optical components for directing a beam of light through the eye for reflection from the retina. The reflected beam, which includes the refractive aberrations caused by the eye, is then separated into a plurality of individual beams by a lenslet. The plurality of individual beams are then collectively analyzed by a computer to establish an acuity map for the eye. Next, the acuity map is reversed by the computer to generate a negative acuity map, and this negative acuity map is then used to electronically configure the reflective surface of an active mirror in accordance with the negative acuity map. Subsequently, incoming light from a stimulus is reflected from the active mirror, and is thereby precompensated before reaching the eye as an undistorted light beam. It is contemplated by the present invention that a time history of the various active mirror configurations that are required by an eye can be used for diagnostic purposes.

摘要翻译： 用于预补偿眼睛的折射性质的系统包括用于引导光束穿过眼睛以从视网膜反射的光学部件。 包括由眼睛引起的折射像差的反射光束然后通过透镜被分离成多个单独的光束。 然后由计算机共同分析多个单独的波束，以建立眼睛的视力图。 接下来，通过计算机将敏锐度图反转以产生负的视力映射，然后根据负的敏锐度图将该负的敏锐度图用于电动配置主动反射镜的反射表面。 随后，来自激励的入射光从主动反射镜反射，并因此在作为未失真光束到达眼睛之前进行预补偿。 本发明考虑到，眼睛所需的各种主动反射镜构造的时间历程可用于诊断目的。