公开(公告)号：US20130195968A1

公开(公告)日：2013-08-01

申请号：US13808089

申请日：2011-07-06

申请人： Andrew Geall ,  Christian Mandl ,  Derek O'Hagan ,  Manmohan Singh

发明人： Andrew Geall ,  Christian Mandl ,  Derek O'Hagan ,  Manmohan Singh

IPC分类号： A61K9/50

CPC分类号： A61K9/50 ,  A61K9/0019 ,  A61K9/127 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  A61K39/245 ,  A61K2039/53 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55566 ,  C12N15/86 ,  C12N15/88 ,  C12N2710/16134 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2770/36143

摘要： Nucleic acid immunisation is achieved by delivering a self-replicating RNA encapsulated within a small particle. The RNA encodes an immunogen of interest, and the particle may deliver this RNA by mimicking the delivery function of a natural RNA virus. Thus the invention provides a non-virion particle for in vivo delivery of RNA to a vertebrate cell, wherein the particle comprises a delivery material encapsulating a self-replicating RNA molecule which encodes an immunogen. These particles are useful as components in pharmaceutical compositions for immunising subjects against various diseases.

摘要翻译： 通过递送封装在小颗粒内的自我复制RNA来实现核酸免疫。 RNA编码感兴趣的免疫原，并且颗粒可以通过模拟天然RNA病毒的递送功能递送该RNA。 因此，本发明提供了用于体内将RNA递送至脊椎动物细胞的非病毒颗粒，其中所述颗粒包含封装编码免疫原的自复制RNA分子的递送材料。 这些颗粒可用作免疫针对各种疾病的受试者的药物组合物中的组分。

公开(公告)号：US20130177639A1

公开(公告)日：2013-07-11

申请号：US13808085

申请日：2011-07-06

申请人： Andrew Geall ,  Katrin Ramsauer ,  Gillis Otten ,  Christian Mandl

发明人： Andrew Geall ,  Katrin Ramsauer ,  Gillis Otten ,  Christian Mandl

IPC分类号： A61K31/7088

CPC分类号： A61K31/7088 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/55555 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2770/36143

摘要： RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.

摘要翻译： 编码免疫原的RNA在递送部位共同递送到非免疫细胞，并且还可以渗入到递送部位的免疫细胞。 这两种细胞类型对相同递送的RNA的反应导致两种不同的作用，其相互作用以产生针对免疫原的强烈免疫应答。 非免疫细胞翻译RNA并表达免疫原。 渗透性免疫细胞通过表达产生局部佐剂作用的I型干扰素和促炎细胞因子来响应RNA，其作用于表达免疫原的非免疫细胞上调主要组织相容性复合物表达，从而增加翻译的蛋白质向T 细胞。 对免疫和非免疫细胞的影响可以通过单次递送单个RNA来实现，例如， 通过单次注射。

公开(公告)号：US20070050211A1

公开(公告)日：2007-03-01

申请号：US11508456

申请日：2006-08-23

申请人： Christian Mandl

发明人： Christian Mandl

IPC分类号： G06Q50/00 ,  G02B7/182 ,  G02B5/08

CPC分类号： A47G1/04 ,  A45D44/005 ,  G06Q50/22

摘要： A tinted mirror which has been treated to reflect a modified image of skin is used to allow a subject to consider a potential change of the appearance of his/her skin, which would follow from the application of a cosmetic product such as self-tanning product. The mirror may be tinted with a brown hue so as to reflect an image that corresponds to the change of coloration of skin after the application of a self-tanning product. The invention may be used in beauty parlor or supermarket aisle to help a subject visualize the potential effect of a self-tanning product on his/her skin.

摘要翻译： 用于反映皮肤修饰图像的已被处理的有色镜用于允许受试者考虑其皮肤外观的潜在变化，这将随着化妆品的应用而得到，例如自鞣制品 。 镜子可以着色为棕色色调，以便在施用自晒黑产品之后反映与皮肤着色变化相对应的图像。 本发明可用于美容院或超市通道，以帮助受试者将自鞣产品在其皮肤上的潜在影响视觉化。