公开(公告)号：US08795722B2

公开(公告)日：2014-08-05

申请号：US11495124

申请日：2006-07-28

申请人： Naosuke Maruyama

发明人： Naosuke Maruyama

IPC分类号： A61K9/20 ,  A61K31/715

CPC分类号： A61K9/2866

摘要： The present invention is a composition for coating comprising a wet-milled product obtained by suspending low-substituted cellulose ether having a molar substitution of from 0.05 to 1.0 per anhydrous glucose unit in water and then applying a shear force to the aqueous dispersion. The present invention is also a coated preparation prepared using the composition for coating so as to mask an unpleasant taste and to control a sticky or slimy feel by administration.

摘要翻译： 本发明是一种用于涂料的组合物，其包括通过将水无机葡萄糖单元的摩尔取代度为0.05-1.0的低取代纤维素醚悬浮在水分散体中，然后施加剪切力而获得的湿磨产物。 本发明也是使用该涂料组合物制备的涂布制剂，以掩盖令人不愉快的味道，并通过给药控制粘稠或粘稠的感觉。

公开(公告)号：US07803196B2

公开(公告)日：2010-09-28

申请号：US11168418

申请日：2005-06-29

申请人： Naosuke Maruyama ,  Kazuhisa Hayakawa ,  Soji Tanioka ,  Hidenori Tsuduki ,  Tsuyoshi Shikano ,  Hiroshi Kawamura ,  Tsuneo Hayata

发明人： Naosuke Maruyama ,  Kazuhisa Hayakawa ,  Soji Tanioka ,  Hidenori Tsuduki ,  Tsuyoshi Shikano ,  Hiroshi Kawamura ,  Tsuneo Hayata

IPC分类号： D06M23/00 ,  D06M11/00 ,  D06M13/00 ,  C08B1/00

CPC分类号： D06M15/09 ,  D06M13/11 ,  D06M13/12 ,  D06M13/395 ,  D06M15/55

摘要： A method for modifying fibers is provided, which method comprises suspending and dispersing in water under shear force a cellulose ether having such a low degree of substitution that a molar degree of substitution with an alkyl group and/or a hydroxyalkyl group ranges from 0.05 to 1.3, applying the resulting dispersion and a crosslinking agent or an aqueous resin emulsion to fibers, and thermally treating the applied fibers.

摘要翻译： 提供了一种改性纤维的方法，该方法包括在剪切力下在水中悬浮和分散具有低取代度的纤维素醚，使得烷基和/或羟烷基的摩尔取代度为0.05-1.3 将所得分散体和交联剂或水性树脂乳液涂布到纤维上，并对所施加的纤维进行热处理。

公开(公告)号：US20060000026A1

公开(公告)日：2006-01-05

申请号：US11168372

申请日：2005-06-29

申请人： Naosuke Maruyama ,  Kazuhisa Hayakawa ,  Soji Tanioka

发明人： Naosuke Maruyama ,  Kazuhisa Hayakawa ,  Soji Tanioka

IPC分类号： D06M11/00

CPC分类号： D06M15/09 ,  D06M13/11 ,  D06M13/12 ,  D06M13/395 ,  D06M15/55

摘要： A method for modifying fibers is provided, which method comprises dispersing in water or a dilute alkali aqueous solution under shear a cellulose ether having such a low degree of substitution that a molar degree of substitution with an alkyl group and/or a hydoxyalkyl group ranges from 0.05 to 1.3, applying the resulting dispersion to fibers, and drying the applied fibers.

摘要翻译： 提供了一种改性纤维的方法，该方法包括在剪切下在水或稀碱水溶液中分散具有低取代度的纤维素醚，使得烷基和/或羟烷基的摩尔取代度范围为 0.05至1.3，将所得分散体施加到纤维上，并干燥所施加的纤维。

公开(公告)号：US5837291A

公开(公告)日：1998-11-17

申请号：US657691

申请日：1996-05-31

申请人： Naosuke Maruyama ,  Hiroyasu Kokubo

发明人： Naosuke Maruyama ,  Hiroyasu Kokubo

IPC分类号： A61K9/00 ,  A61K9/30 ,  A61K9/50 ,  A61K9/52 ,  A61K45/00 ,  A61K47/14 ,  A61K47/32 ,  A61K47/38 ,  A61K9/14 ,  A61K9/28 ,  A61K9/54

CPC分类号： A61K9/5078 ,  A61K9/5089

摘要： An enteric preparation prepared by coating a solid dosage form with a fine powder enteric coating agent while spraying a liquid plasticizer.

摘要翻译： 通过在喷洒液体增塑剂的同时用细粉肠溶包衣剂涂布固体剂型制备的肠溶制剂。

公开(公告)号：US20110230656A1

公开(公告)日：2011-09-22

申请号：US13043113

申请日：2011-03-08

申请人： Naosuke Maruyama ,  Yasuyuki Hirama

发明人： Naosuke Maruyama ,  Yasuyuki Hirama

IPC分类号： C08B11/08

CPC分类号： C08B11/02 ,  A61K9/0056 ,  A61K9/2054 ,  A61K31/167 ,  A61K47/18

摘要： Provided is nonionic and excellently stable low-substituted hydroxypropylcellulose having improved compressibility and flowability, and further having improved disintegration and texture in oral cavity. More specifically provided is low-substituted hydroxypropylcellulose having a crystallinity of 60% or less, a degree of hydroxypropoxyl substitution of 5 to 9% by weight, and an aspect ratio of less than 2.5, wherein the crystallinity is calculated based on a diffraction intensity by wide-angle X-ray diffraction measurement according to the following formula (1): Crystallinity(%)={(Ic−Ia)/Ic}×100  (1) wherein Ic means a diffraction intensity at a diffraction angle 2θ of 22.5° and Ia means a diffraction intensity at a diffraction angle 2θ of 18.5°.

摘要翻译： 本发明提供了具有改进的可压缩性和流动性的非离子和非常稳定的低取代羟丙基纤维素，并且还具有口腔改善的崩解和质地。 更具体地提供了结晶度为60％以下，羟丙氧基取代度为5〜9重量％，长径比小于2.5的低取代羟丙基纤维素，其中结晶度基于衍射强度由 根据下式（1）的广角X射线衍射测定：结晶度（％）= {（Ic-Ia）/ Ic}×100（1）其中，Ic表示衍射角2°时的衍射强度; 为22.5°，Ia表示衍射角2°时的衍射强度; 为18.5°。

公开(公告)号：US07985855B2

公开(公告)日：2011-07-26

申请号：US11168372

申请日：2005-06-29

申请人： Naosuke Maruyama ,  Kazuhisa Hayakawa ,  Soji Tanioka

发明人： Naosuke Maruyama ,  Kazuhisa Hayakawa ,  Soji Tanioka

IPC分类号： D06M15/09 ,  C08B11/02 ,  C08B11/08

CPC分类号： D06M15/09 ,  D06M13/11 ,  D06M13/12 ,  D06M13/395 ,  D06M15/55

摘要： A method for modifying fibers is provided, which method comprises dispersing in water or a dilute alkali aqueous solution under shear a cellulose ether having such a low degree of substitution that a molar degree of substitution with an alkyl group and/or a hydoxyalkyl group ranges from 0.05 to 1.3, applying the resulting dispersion to fibers, and drying the applied fibers.

摘要翻译： 提供了一种改性纤维的方法，该方法包括在剪切下在水或稀碱水溶液中分散具有低取代度的纤维素醚，使得烷基和/或羟烷基的摩尔取代度范围为 0.05至1.3，将所得分散体施加到纤维上，并干燥所施加的纤维。

公开(公告)号：US20060000027A1

公开(公告)日：2006-01-05

申请号：US11168403

申请日：2005-06-29

申请人： Masaaki Furuta ,  Tsuyoshi Shikano ,  Hiroshi Kawamura ,  Tsuneo Hayata ,  Naosuke Maruyama ,  Kazuhisa Hayakawa ,  Soji Tanioka

发明人： Masaaki Furuta ,  Tsuyoshi Shikano ,  Hiroshi Kawamura ,  Tsuneo Hayata ,  Naosuke Maruyama ,  Kazuhisa Hayakawa ,  Soji Tanioka

IPC分类号： D06M11/00

CPC分类号： D06M15/09 ,  D06M2200/50

摘要： A method for modifying fibers comprises steps of adding a crosslinking agent and/or an aqueous resin emulsion to an alkali aqueous solution dissolving therein a cellulose ether having such a low degree of substitution that a molar degree of substitution with an alkyl group and/or a hydroxyalkyl group ranges 0.05 to 1.3, applying the resulting solution to fibers, neutralizing the applied solution with an acid for coagulation, and thermally treating the fibers. Alternatively, the method comprises adding a crosslinking agent and/or an aqueous resin emulsion to an alkali aqueous solution dissolving therein a cellulose ether having such a low degree of substitution that a molar degree of substitution with an alkyl group and/or a hydroxyalkyl group ranges 0.05 to 1.3, applying the resulting solution to fibers, thermally treating the thus applied fibers, and applying an acid to the fibers to neutralize the alkali left on the fibers.

摘要翻译： 改性纤维的方法包括以下步骤：向溶解有其中具有低取代度的纤维素醚的碱性水溶液中加入交联剂和/或水性树脂乳液，使用烷基和/或 羟基烷基的范围为0.05至1.3，将所得溶液施加到纤维上，用酸凝固所述溶液中和，并热处理纤维。 或者，该方法包括向溶解有其中具有低取代度的纤维素醚的碱性水溶液中加入交联剂和/或水性树脂乳液，使得烷基和/或羟烷基的取代摩尔量范围 0.05至1.3，将所得溶液施加到纤维上，热处理如此施加的纤维，并向纤维施加酸以中和留在纤维上的碱。

公开(公告)号：US20050244483A1

公开(公告)日：2005-11-03

申请号：US11117260

申请日：2005-04-28

申请人： Naosuke Maruyama

发明人： Naosuke Maruyama

IPC分类号： A61K8/02 ,  A61K8/73 ,  A61K9/70 ,  A61K48/00 ,  A61Q19/00

CPC分类号： A61K8/731 ,  A61K8/0208 ,  A61K9/7007 ,  A61K48/00 ,  A61K2800/412 ,  A61Q19/00

摘要： An object is to provide a film preparation comprising a polymer harmless to living bodies and being highly adhesive to the skin; and a film preparation further containing a pharmaceutically active oily ingredient and being highly adhesive to the skin. More specifically, provided is a film preparation comprising a drug, a wetly shear-triturated low-substituted cellulose ether having a molar substitution of from 0.05 to 1.0 per anhydrous glucose unit, and a water-soluble cellulose ether, and having 100 minutes or greater of adhesion ability to the skin. The preparation becomes a skin-adhesive hydrous sheet having excellent skin adhesion after it is wet with water as it is used.

摘要翻译： 本发明的目的是提供一种包含对活体无害的聚合物并且对皮肤高度粘合的膜制剂; 还含有药物活性油性成分并且对皮肤高度粘合的薄膜制剂。 更具体地说，提供了一种包含药物的薄膜制剂，每无水葡萄糖单元摩尔取代为0.05-1.0的湿剪切研磨的低取代纤维素醚和水溶性纤维素醚，并且具有100分钟以上 对皮肤的粘附能力。 该制剂成为在使用后用水润湿后具有优异的皮肤粘附性的皮肤粘合性水合片。

公开(公告)号：US08822675B2

公开(公告)日：2014-09-02

申请号：US13043113

申请日：2011-03-08

申请人： Naosuke Maruyama ,  Yasuyuki Hirama

发明人： Naosuke Maruyama ,  Yasuyuki Hirama

IPC分类号： C08B11/08 ,  A61K31/167 ,  A61K9/00 ,  A61K47/18 ,  C08B11/02 ,  A61K9/20

CPC分类号： C08B11/02 ,  A61K9/0056 ,  A61K9/2054 ,  A61K31/167 ,  A61K47/18

摘要： Provided is nonionic and excellently stable low-substituted hydroxypropylcellulose having improved compressibility and flowability, and further having improved disintegration and texture in oral cavity. More specifically provided is low-substituted hydroxypropylcellulose having a crystallinity of 60% or less, a degree of hydroxypropoxyl substitution of 5 to 9% by weight, and an aspect ratio of less than 2.5, wherein the crystallinity is calculated based on a diffraction intensity by wide-angle X-ray diffraction measurement according to the following formula (1): Crystallinity(%)={(Ic−Ia)/Ic}×100  (1) wherein Ic means a diffraction intensity at a diffraction angle 2θ of 22.5° and Ia means a diffraction intensity at a diffraction angle 2θ of 18.5°.

摘要翻译： 本发明提供了具有改进的可压缩性和流动性的非离子和非常稳定的低取代羟丙基纤维素，并且还具有口腔改善的崩解和质地。 更具体地提供了结晶度为60％以下，羟丙氧基取代度为5〜9重量％，长径比小于2.5的低取代羟丙基纤维素，其中结晶度基于衍射强度由 根据下式（1）的广角X射线衍射测定：结晶度（％）= {（Ic-Ia）/ Ic}×100（1）其中，Ic表示衍射角2°时的衍射强度; 为22.5°，Ia表示衍射角2°时的衍射强度; 为18.5°。

公开(公告)号：US08784883B2

公开(公告)日：2014-07-22

申请号：US13222600

申请日：2011-08-31

申请人： Kazuhisa Hayakawa ,  Naosuke Maruyama ,  Miyuki Fukasawa

发明人： Kazuhisa Hayakawa ,  Naosuke Maruyama ,  Miyuki Fukasawa

IPC分类号： A61K9/48 ,  A61K9/62

CPC分类号： A61K9/4816

摘要： A capsule with good disintegration properties that can quickly display its content's efficacy as well as a method for preparing the same are provided. More specifically, provided is a capsule comprising a shell comprising low-substituted cellulose ether. Also, provided is a method for preparing a hard capsule comprising the low-substituted cellulose ether comprising a step of covering a pin for forming the hard capsule with the low-substituted cellulose ether by immersing the pin in an alkaline solution of the low-substituted cellulose ether; a step of forming the low-substituted cellulose on a surface of the pin into a gel by further immersing the covered pin in an aqueous acid solution; a step of washing by immersing the pin whose surface has been covered with the gel in water; and a step of drying.

摘要翻译： 提供了具有快速显示其内容效力的具有良好崩解性能的胶囊以及其制备方法。 更具体地，提供了包含包含低取代的纤维素醚的壳的胶囊。 此外，提供了一种制备包含低取代纤维素醚的硬胶囊的方法，其包括通过将针浸入低取代的纤维素的碱性溶液中来覆盖用低硬脂醇形成硬胶囊的销的步骤 纤维素醚; 通过将覆盖的针进一步浸入酸水溶液中，将销钉的表面上的低取代纤维素形成凝胶的步骤; 通过将其表面已经被凝胶覆盖的销浸渍在水中来洗涤的步骤; 和干燥步骤。