公开(公告)号：US09969761B2

公开(公告)日：2018-05-15

申请号：US14258247

申请日：2014-04-22

申请人： GE HEALTHCARE LIMITED ,  GE HEALTHCARE AS

发明人： Torild Wickstrom ,  Dirk-Jan In't Veld ,  Nigel John Osborn ,  Julian Grigg ,  Anthony Wilson

IPC分类号： C07H13/04 ,  C07H1/00

CPC分类号： C07H5/00 ,  C07H1/00 ,  C07H5/02 ,  C07H13/04

摘要： The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.