公开(公告)号：US09982058B2

公开(公告)日：2018-05-29

申请号：US15373275

申请日：2016-12-08

Applicant: Genentech, Inc.

Inventor： Dorothy French ,  Erik Huntzicker ,  Christian W. Siebel

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  A61K47/48 ,  C07K14/47 ,  C07K14/475 ,  A61K39/00

CPC classification number: C07K16/2896 ,  A61K39/3955 ,  A61K39/39558 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C07K16/303 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76

Abstract: The present invention relates to methods of treating liver cancer using a Notch signaling inhibitor. Compositions and methods for the treatment of liver cancers are also provided.

公开(公告)号：US20170342488A1

公开(公告)日：2017-11-30

申请号：US15608603

申请日：2017-05-30

Applicant: Genentech, Inc.

Inventor： Rama PAI ,  Donna M. Dambach ,  Dorothy French ,  Veronique V. Lauriault

IPC: C12Q1/68 ,  A61K39/395 ,  C07K16/22 ,  A61K39/00

CPC classification number: C12Q1/6876 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/70

Abstract: Provided herein are methods of using FGF19 modulators and/or bile acid metabolism biomarkers.

公开(公告)号：US20170210815A1

公开(公告)日：2017-07-27

申请号：US15373275

申请日：2016-12-08

Applicant: Genentech, Inc.

Inventor： Dorothy French ,  Erik Huntzicker ,  Christian W. Siebel

IPC: C07K16/28 ,  C07K16/30

CPC classification number: C07K16/2896 ,  A61K39/3955 ,  A61K39/39558 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C07K16/303 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76

Abstract: The present invention relates to methods of treating liver cancer using a Notch signaling inhibitor. Compositions and methods for the treatment of liver cancers are also provided.

公开(公告)号：US20140030259A1

公开(公告)日：2014-01-30

申请号：US13952072

申请日：2013-07-26

Applicant: Genentech, Inc.

Inventor： Dorothy French

IPC: A61K39/395 ,  G01N33/574

CPC classification number: C07K16/2863 ,  A61K39/395 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/76 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/531 ,  G01N33/57484 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2333/71 ,  G01N2333/96494

Abstract: Provided herein are biomarkers and therapies for the treatment of pathological conditions, such as cancer, and method of using FGFR3 antagonists. In particular, provided is FGFR3 as a biomarker for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

Abstract translation: 本文提供了用于治疗诸如癌症的病理状况的生物标志物和疗法，以及使用FGFR3拮抗剂的方法。 特别地，提供了FGFR3作为癌症患者选择和预后的生物标志物，以及治疗性治疗方法，制造方法及其制备方法，诊断试剂盒，检测方法和与之相关的广告方法。