公开(公告)号：US11091553B2

公开(公告)日：2021-08-17

申请号：US15832337

申请日：2017-12-05

Applicant: GENMAB A/S

Inventor： Bart De Goeij ,  Simone De Haij ,  Thilo Riedl ,  Rene Hoet ,  Ole Baadsgaard ,  Jan Van De Winkel ,  David Satijn ,  Paul Parren ,  Aran Frank Labrijn ,  Joyce Meesters ,  Janine Schuurman ,  Edward N. Van Den Brink

IPC: C07K16/28 ,  C07K16/32 ,  A61K39/00

Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US10752695B2

公开(公告)日：2020-08-25

申请号：US15197496

申请日：2016-06-29

Applicant: GENMAB A/S

Inventor： Jan Van De Winkel ,  Tom Vink ,  Janine Schuurman ,  Paul Parren ,  Rob Aalberse ,  Marijn Van Der Neut Kolfschoten

IPC: C07K16/00 ,  C12P21/08 ,  C07K16/28 ,  A61K51/10 ,  A61K47/68 ,  C07K16/16 ,  C07K16/18 ,  C07K1/00 ,  A61K39/00

Abstract: The present invention relates to novel stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).

公开(公告)号：US20150368345A1

公开(公告)日：2015-12-24

申请号：US14739771

申请日：2015-06-15

Applicant: Genmab A/S

Inventor： Aran Frank Labrijn ,  Stefan Loverix ,  Paul Parren ,  Jan Van De Winkel ,  Janine Schuurman ,  Ignace Laster

IPC: C07K16/28

Abstract: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of lgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.

Abstract translation: 本发明涉及抗体的恒定区，特别是1gG4的CH3区，其影响CH3-CH3相互作用强度的位置。 公开了稳定或不稳定这种相互作用的突变。

公开(公告)号：US20130345406A1

公开(公告)日：2013-12-26

申请号：US13912581

申请日：2013-06-07

Applicant: Genmab A/S

Inventor： Jan Van De Winkel ,  Tom Vink ,  Janine Schuurman ,  Paul Parren ,  Rob Aalberse ,  Marijn Van Der Neut Kolfschoten

IPC: C07K16/18 ,  C07K16/16

CPC classification number: C07K16/2887 ,  A61K47/6803 ,  A61K47/6813 ,  A61K47/6835 ,  A61K47/6839 ,  A61K47/6845 ,  A61K47/6849 ,  A61K51/10 ,  A61K51/1006 ,  A61K51/1021 ,  A61K51/1027 ,  A61K51/103 ,  A61K51/1039 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/16 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/94

Abstract: The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).

Abstract translation: 本发明涉及稳定的IgG4抗体，涉及产生此类抗体的方法以及此类抗体作为药物的用途。 在一个主要方面，本发明涉及一种稳定的IgG4抗体，其包含重链和轻链，其中所述重链包含具有在位置（409）处的Arg残基取代的人IgG4恒定区， 位置（405）或位置（370）处的Lys残基。

公开(公告)号：US10793640B2

公开(公告)日：2020-10-06

申请号：US15627921

申请日：2017-06-20

Applicant: GENMAB A/S

Inventor： Bart De Goeij ,  Edward N. Van Den Brink ,  Simone De Haij ,  Thilo Riedl ,  Rene Hoet ,  Ole Baadsgaard ,  David Satijn ,  Jan Van De Winkel ,  Paul Parren

IPC: C07K16/30 ,  A61K39/395 ,  C07K16/32 ,  A61K39/00

Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US10597464B2

公开(公告)日：2020-03-24

申请号：US15414122

申请日：2017-01-24

Applicant: GENMAB A/S

Inventor： Aran Frank Labrijn ,  Joyce I. Meesters ,  Ewald T. J. Van Den Bremer ,  Joost J. Neijssen ,  Patrick Van Berkel ,  Bart De Goeij ,  Tom Vink ,  Jan Van De Winkel ,  Janine Schuurman ,  Paul Parren

IPC: C07K16/46 ,  C07K16/10 ,  C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  G01N33/68 ,  A61K39/00

Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.

公开(公告)号：US09663578B2

公开(公告)日：2017-05-30

申请号：US14317600

申请日：2014-06-27

Applicant: GENMAB A/S

Inventor： Edward Norbert Van Den Brink ,  Paul Parren ,  Jan Van De Winkel ,  Aran Frank Labrijn ,  Frank Everhardus Martinus Rebers ,  Esther Cornelia Wilhelmina Breij

IPC: A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/283 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/92

Abstract: Isolated monoclonal antibodies which bind to human CD32b and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US11866514B2

公开(公告)日：2024-01-09

申请号：US16777053

申请日：2020-01-30

Applicant: GENMAB A/S

Inventor： Aran Frank Labrijn ,  Joyce I. Meesters ,  Ewald T. J. Van Den Bremer ,  Joost J. Neijssen ,  Patrick Van Berkel ,  Bart De Goeij ,  Tom Vink ,  Jan Van De Winkel ,  Janine Schuurman ,  Paul Parren

IPC: C07K16/46 ,  C07K16/10 ,  C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/468 ,  C07K16/1063 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/32 ,  C07K16/40 ,  G01N33/6854 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.

公开(公告)号：US11230604B2

公开(公告)日：2022-01-25

申请号：US15909540

申请日：2018-03-01

Applicant: GENMAB A/S

Inventor： Michel De Weers ,  Tim Walseth ,  Jan Van De Winkel ,  Tom Vink ,  Paul Parren

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  G01N33/573

Abstract: Isolated monoclonal antibodies which bind to human CD38 and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US10000570B2

公开(公告)日：2018-06-19

申请号：US14739768

申请日：2015-06-15

Applicant: Genmab A/S

Inventor： Aran Frank Labrijn ,  Stefan Loverix ,  Paul Parren ,  Jan Van De Winkel ,  Janine Schuurman ,  Ignace Lasters

IPC: C07K16/28 ,  C07K16/00 ,  A61K39/395 ,  A61K47/48 ,  A61K51/10 ,  A61K39/00

Abstract: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.