公开(公告)号：US20170080076A1

公开(公告)日：2017-03-23

申请号：US15368429

申请日：2016-12-02

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Maria ARICÒ ,  Maurizio COMANDUCCI ,  Cesira GALEOTTI ,  Vega MASIGNANI ,  Marzia Monica GIULIANI ,  Mariagrazia PIZZA

IPC: A61K39/095

CPC classification number: A61K39/095 ,  A61K38/00 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/572 ,  A61K2039/575 ,  C07K14/22 ,  C07K2319/00 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/689 ,  C12Q2600/156

Abstract: Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae are disclosed. These approaches typically affect the level of expression, the ease of purification, the cellular localization, and/or the immunological properties of the expressed protein.

公开(公告)号：US20160030545A1

公开(公告)日：2016-02-04

申请号：US14804756

申请日：2015-07-21

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Claire FRASER ,  Cesira GALEOTTI ,  Guido GRANDI ,  Erin HICKEY ,  Vega MASIGNANI ,  Marirosa MORA ,  Jeremy PETERSEN ,  Mariagrazia PIZZA ,  Rino RAPPUOLI ,  Giulio RATTI ,  Vincenzo SCARLATO ,  Maria SCARSELLI ,  Herve TETTELIN ,  J. Craig VENTER

IPC: A61K39/095 ,  C07K14/22

CPC classification number: C07K14/22 ,  A61K38/00 ,  A61K39/00 ,  A61K39/095 ,  A61K2039/55505 ,  Y10S530/806 ,  Y10S530/825

Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.

公开(公告)号：US20160024157A1

公开(公告)日：2016-01-28

申请号：US14876623

申请日：2015-10-06

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA ,  J. CRAIG VENTER INSTITUTE, INC.

Inventor： Vega MASIGNANI ,  Rino RAPPUOLI ,  Herve TETTELIN

IPC: C07K14/285 ,  A61K39/102 ,  C07K16/12

CPC classification number: C07K14/285 ,  A61K39/00 ,  A61K39/102 ,  A61K39/12 ,  C07K14/005 ,  C07K16/1242

Abstract: Polypeptides comprising various amino acid sequences derived from Haemophilus influenzae type b, including a number of lipoproteins. These can be used in the development of vaccines for preventing and/or treating bacterial meningitis. They may also be useful for diagnostic purposes, and as targets for antibiotics. Antibodies against the polypeptides are also disclosed, as are the coding nucleic acids.

Abstract translation: 包含衍生自b型流感嗜血杆菌的各种氨基酸序列的多肽，包括许多脂蛋白。 这些可用于开发用于预防和/或治疗细菌性脑膜炎的疫苗。 它们也可用于诊断目的，也可用作抗生素的靶标。 编码核酸也公开了抗多肽的抗体。