-
公开(公告)号：US20220401734A1
公开(公告)日：2022-12-22
申请号：US17872319
申请日：2022-07-25
Applicant: Galvani Bioelectronics Limited
Inventor： Matteo Donega , Daniel John Chew , Isha Gupta
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.
-
公开(公告)号：US20230347140A1
公开(公告)日：2023-11-02
申请号：US18213964
申请日：2023-06-26
Applicant: Galvani Bioelectronics Limited
Inventor： Matteo Donega , Daniel John Chew , Margarita J. Vervoordeldonk , Isha Gupta
CPC classification number: A61N1/0556 , A61N1/0553 , A61N1/36053 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36135 , A61N1/36171 , A61N1/3787
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.
-
公开(公告)号：US11724108B2
公开(公告)日：2023-08-15
申请号：US17872703
申请日：2022-07-25
Applicant: Galvani Bioelectronics Limited
Inventor： Daniel John Chew , Matteo Donega , Isha Gupta
CPC classification number: A61N1/36071 , A61N1/0553 , A61N1/0556 , A61N1/205 , A61N1/3616 , A61N1/36135 , A61N1/36171
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.
-
公开(公告)号：US11577080B2
公开(公告)日：2023-02-14
申请号：US15523914
申请日：2015-11-03
Applicant: GALVANI BIOELECTRONICS LIMITED , FACULDADE DE CIÊNCIAS MÉDICAS DA UNIVERSIDADA NOVA DE LISBOA
Inventor： Silvia Margarida Vilares Santos Conde , Daniel John Chew , Hans Jakob Kristoffer Famm , Maria Pedro Sucena Guarino , Brad Holinski , Sonal Patel
Abstract: The invention refers to a device for inhibiting the neural activity of a carotid sinus nerve (CSN) or carotid body of a subject, the device comprising: one or more transducers configured to apply a signal to the CSN or associated carotid body of the subject, optionally at least two such transducers; and a controller coupled to the one or more transducers, the controller controlling the signal to be applied by the one or more transducers, such that the signal inhibits the neural activity of the CSN or carotid body to produce a physiological response in the subject, wherein the physiological response is one or more of the group consisting of: an increase in insulin sensitivity in the subject, an increase in glucose tolerance in the subject, a decrease in (fasting) plasma glucose concentration in the subject, a reduction in subcutaneous fat content in the subject, and a reduction in obesity in the subject.
-
公开(公告)号：US20220401731A1
公开(公告)日：2022-12-22
申请号：US17872703
申请日：2022-07-25
Applicant: Galvani Bioelectronics Limited
Inventor： Daniel John Chew , Matteo Donega , Isha Gupta
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.
-
Patent Agency Ranking
公开(公告)号：US11446496B2
公开(公告)日：2022-09-20
申请号：US16955393
申请日：2018-12-20
Applicant: Galvani Bioelectronics Limited
Inventor： Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
-
公开(公告)号：US20250128064A1
公开(公告)日：2025-04-24
申请号：US18930609
申请日：2024-10-29
Applicant: Galvani Bioelectronics Limited
Inventor： Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro-and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
-
公开(公告)号：US20240390678A1
公开(公告)日：2024-11-28
申请号：US18790835
申请日：2024-07-31
Applicant: Galvani Bioelectronics Limited
Inventor： Matteo Donega , Daniel John Chew , Isha Gupta
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.
-
公开(公告)号：US20240350809A1
公开(公告)日：2024-10-24
申请号：US18742863
申请日：2024-06-13
Applicant: Galvani Bioelectronics Limited
Inventor： David Karl Lee Peterson , Daniel John Chew , Matteo Donega , Xu Meng
CPC classification number: A61N1/36167 , A61N1/0551
Abstract: A system (1) for electrically stimulating a nerve (3), the system comprising: a first stimulator (5) and a second stimulator (7) for electrically stimulating the nerve, the first stimulator and the second stimulator spaced apart from one another by a first distance; and a controller (9) arranged to: a) set a time interval as a function of the first distance and the speed of propagation of an action potential in the nerve; b) activate the first stimulator for a first stimulation period, thus inducing electrical activity in the nerve; and c) activate the second stimulator for a second stimulation period after the time interval has elapsed after the end of the first time period.
-
公开(公告)号：US20230285752A1
公开(公告)日：2023-09-14
申请号：US18141045
申请日：2023-04-28
Applicant: Galvani Bioelectronics Limited
Inventor： Daniel John Chew , Matteo Donega , Isha Gupta
CPC classification number: A61N1/36071 , A61N1/0553 , A61N1/0556 , A61N1/205 , A61N1/36135 , A61N1/3616 , A61N1/36171
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.
-
-
-
-
-
-
-
-
-
Search Results
26
records
(took 0.015 seconds)
