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公开(公告)号：US11577080B2
公开(公告)日：2023-02-14
申请号：US15523914
申请日：2015-11-03
发明人： Silvia Margarida Vilares Santos Conde , Daniel John Chew , Hans Jakob Kristoffer Famm , Maria Pedro Sucena Guarino , Brad Holinski , Sonal Patel
摘要： The invention refers to a device for inhibiting the neural activity of a carotid sinus nerve (CSN) or carotid body of a subject, the device comprising: one or more transducers configured to apply a signal to the CSN or associated carotid body of the subject, optionally at least two such transducers; and a controller coupled to the one or more transducers, the controller controlling the signal to be applied by the one or more transducers, such that the signal inhibits the neural activity of the CSN or carotid body to produce a physiological response in the subject, wherein the physiological response is one or more of the group consisting of: an increase in insulin sensitivity in the subject, an increase in glucose tolerance in the subject, a decrease in (fasting) plasma glucose concentration in the subject, a reduction in subcutaneous fat content in the subject, and a reduction in obesity in the subject.
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公开(公告)号：US11571574B2
公开(公告)日：2023-02-07
申请号：US16348924
申请日：2017-11-10
摘要： Modulation of neural activity in the superior laryngeal nerve (SLN) or cervical sympathetic trunk (CST) is effective in treating diseases and conditions mediated by thyroid and parathyroid hormones, in particular diseases associated with calcitonin secretion (e.g. osteoporosis) or diseases associated with thyroxine secretion (e.g. hypothyroid syndrome).
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公开(公告)号：US10406362B2
公开(公告)日：2019-09-10
申请号：US15551592
申请日：2016-02-19
摘要： Methods for treating polycystic ovarian syndrome with a neuromodulation device that modulates sympathetic neural activity are described herein. The neuromodulation device is an apparatus for the treatment of polycystic ovarian syndrome. In one aspect, the apparatus decreases the neural activity of a postganglionic ovary-innervating sympathetic nerve. Modulation in neural activity may be achieved using an apparatus comprising one or more stimulators each configured to apply a signal to a postganglionic ovary-innervating sympathetic nerve of the patient, a controller coupled to the one or more stimulators, the controller controlling the signal to be applied by each of the one or more stimulators, such that the signal decreases the neural activity of the nerve to produce a physiological and/or biochemical response in the patient, wherein the physiological and/or biochemical response comprises an improvement in one or more symptoms of polycystic ovarian syndrome.
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公开(公告)号：US10974041B2
公开(公告)日：2021-04-13
申请号：US15568964
申请日：2016-04-22
发明人： Daniel John Chew , Wouter Jacob De Jonge , Hans Jakob Kristoffer Famm , Sonal Patel , Olaf Welting
摘要： The invention provides devices, apparatuses, systems and methods for treating and ameliorating inflammation of the gut. In particular, the invention provides devices, apparatuses and methods in which a neuromodulatory signal is delivered a splenic nerve and/or superior mesenteric plexus (SMP). The signal is able to treat inflammatory disorders, e.g., colitis, for example in Inflammatory Bowel Disease.
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