公开(公告)号：US09018357B2

公开(公告)日：2015-04-28

申请号：US13926801

申请日：2013-06-25

Applicant: Genentech, Inc.

Inventor： Germaine Fuh ,  Hans-Peter Gerber ,  Wei-Ching Liang ,  Frederic Fellouse ,  Sachdev S. Sidhu ,  Christian Wiesmann

IPC: C07K16/22 ,  C07K16/18 ,  C07K16/00 ,  C07K16/32 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K16/005 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6845

Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

公开(公告)号：US20140187754A1

公开(公告)日：2014-07-03

申请号：US14197072

申请日：2014-03-04

Applicant: Genentech, Inc.

Inventor： Avi Ashkenazi ,  Jing Qing ,  Christian Wiesmann ,  Yan Wu

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  A61K39/395 ,  A61K39/3955 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/3038 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/30

Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.

Abstract translation: 本发明提供FGFR3抗体，以及组合物和使用这些抗体的方法。