公开(公告)号：US20220064315A1

公开(公告)日：2022-03-03

申请号：US17322671

申请日：2021-05-17

Applicant: Genentech, Inc.

Inventor： Greg LAZAR ,  Yanli YANG ,  Erin H. CHRISTENSEN ,  Julie HANG ,  Jeong KIM ,  Seth HARRIS

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: Provided herein are tetravalent antigen binding complexes having agonist activity for a cell surface receptor. In some embodiments, the complexes comprise binding specificities for multiple epitopes of the same cell surface receptor. Further provided herein are nucleic acids, vectors, host cells, pharmaceutical compositions, and methods of production related thereto.

公开(公告)号：US20220002437A1

公开(公告)日：2022-01-06

申请号：US17483281

申请日：2021-09-23

Applicant: Genentech, Inc.

Inventor： Jeong KIM ,  Jeanne CHEUNG

IPC: C07K16/32 ,  A61K31/337 ,  C07K16/28 ,  A61K45/06 ,  A61K47/64 ,  A61K39/395 ,  A61K31/282 ,  C07K16/30

Abstract: The invention provides methods and compositions for treating cancer and for enhancing immune function in an individual having cancer. The methods comprise administering a PD-1 axis binding antagonist and a taxane.

公开(公告)号：US20210009705A1

公开(公告)日：2021-01-14

申请号：US16911229

申请日：2020-06-24

Applicant: Genentech, Inc.

Inventor： Changchun DU ,  Jeong KIM ,  Jing ZHU ,  Jack BEVERS, III ,  Kevin WALSH ,  Patricia DE ALMEIDA ,  James ANDYA ,  Ye SHEN

IPC: C07K16/28 ,  C07K16/22 ,  A61K47/68 ,  A61K39/395 ,  A61K45/06 ,  C07K16/30

Abstract: The invention provides anti-OX40 antibodies and methods of using the same.

公开(公告)号：US20180022813A1

公开(公告)日：2018-01-25

申请号：US15725208

申请日：2017-10-04

Applicant: Genentech, Inc.

Inventor： Greg LAZAR ,  Jeong KIM ,  Jing ZHU ,  Yanli YANG ,  Randall BREZSKI

IPC: C07K16/28 ,  A61K39/395 ,  A61K38/02 ,  A61K47/68

CPC classification number: C07K16/2875 ,  A61K38/02 ,  A61K39/395 ,  A61K47/6881 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K16/2863 ,  C07K16/2878 ,  C07K16/32 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/622 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/92

Abstract: Provided herein are antigen binding polypeptides and complexes thereof having agonist activity. Also provided are methods for screening for complexes or polypeptides having agonist activity, enhancing the agonist activity of a polypeptide, and for agonizing a cell surface receptor using the complexes and polypeptide described herein.

公开(公告)号：US20170015755A1

公开(公告)日：2017-01-19

申请号：US15280586

申请日：2016-09-29

Applicant: Genentech, Inc.

Inventor： Kevin WALSH ,  Patricia DE ALMEIDA ,  Changchun DU ,  Jeong KIM ,  Jing ZHU ,  Jack BEVERS, III ,  James ANDYA ,  Ye SHEN

IPC: C07K16/28 ,  C07K16/30 ,  C07K16/22

CPC classification number: C07K16/2878 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/22 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/71 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides compositions and methods for treating cancers. The method comprises administering an anti-angiogenesis agent and an OX40 binding agonist.

Abstract translation: 本发明提供了治疗癌症的组合物和方法。 该方法包括施用抗血管发生剂和OX40结合激动剂。

公开(公告)号：US20160257752A1

公开(公告)日：2016-09-08

申请号：US15167125

申请日：2016-05-27

Applicant: Genentech, Inc.

Inventor： Jeong KIM ,  Jeanne CHEUNG

IPC: C07K16/28 ,  C07K16/30 ,  A61K31/282 ,  A61K39/395 ,  A61K31/337 ,  A61K47/48

Abstract: The invention provides methods and compositions for treating cancer and for enhancing immune function in an individual having cancer. The methods comprise administering a PD-1 axis binding antagonist and a taxane.

Abstract translation: 本发明提供了治疗癌症并增强患有癌症的个体的免疫功能的方法和组合物。 所述方法包括施用PD-1轴结合拮抗剂和紫杉烷。

公开(公告)号：US20160166685A1

公开(公告)日：2016-06-16

申请号：US14942896

申请日：2015-11-16

Applicant: GENENTECH, INC.

Inventor： Jeanne CHEUNG ,  Mahrukh HUSENI ,  Jeong KIM

IPC: A61K39/395

CPC classification number: A61K39/39558 ,  A61K38/16 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/507 ,  A61K2039/55 ,  C07K16/2827 ,  C07K16/2878 ,  C07K2317/75 ,  C07K2317/76

Abstract: The invention provides compositions and methods for treating cancers. The method comprises administering a PD-1 axis binding antagonist and an OX40 binding agonist.

公开(公告)号：US20250084185A1

公开(公告)日：2025-03-13

申请号：US18956269

申请日：2024-11-22

Applicant: Genentech, Inc.

Inventor： Jeong KIM ,  Jeanne CHEUNG

IPC: C07K16/32 ,  A61K31/282 ,  A61K31/337 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/64 ,  C07K16/28 ,  C07K16/30

Abstract: The invention provides methods and compositions for treating cancer and for enhancing immune function in an individual having cancer. The methods comprise administering a PD-1 axis binding antagonist and a taxane.

公开(公告)号：US20240309111A1

公开(公告)日：2024-09-19

申请号：US18657996

申请日：2024-05-08

Applicant: Genentech, Inc.

Inventor： Jeong KIM ,  Jeanne CHEUNG

IPC: C07K16/32 ,  A61K31/282 ,  A61K31/337 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/64 ,  C07K16/28 ,  C07K16/30

CPC classification number: C07K16/32 ,  A61K31/282 ,  A61K31/337 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/643 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K16/3069 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention provides methods and compositions for treating cancer and for enhancing immune function in an individual having cancer. The methods comprise administering a PD-1 axis binding antagonist and a taxane.

公开(公告)号：US20220306766A1

公开(公告)日：2022-09-29

申请号：US17711170

申请日：2022-04-01

Applicant: Genentech, Inc.

Inventor： Jeong KIM ,  Jeanne CHEUNG

IPC: C07K16/32 ,  A61K31/337 ,  C07K16/28 ,  A61K45/06 ,  A61K47/64 ,  A61K39/395 ,  A61K31/282 ,  C07K16/30

Abstract: The invention provides methods and compositions for treating cancer and for enhancing immune function in an individual having cancer. The methods comprise administering a PD-1 axis binding antagonist and a taxane.