公开(公告)号：US20180022813A1

公开(公告)日：2018-01-25

申请号：US15725208

申请日：2017-10-04

Applicant: Genentech, Inc.

Inventor： Greg LAZAR ,  Jeong KIM ,  Jing ZHU ,  Yanli YANG ,  Randall BREZSKI

IPC: C07K16/28 ,  A61K39/395 ,  A61K38/02 ,  A61K47/68

CPC classification number: C07K16/2875 ,  A61K38/02 ,  A61K39/395 ,  A61K47/6881 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K16/2863 ,  C07K16/2878 ,  C07K16/32 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/622 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/92

Abstract: Provided herein are antigen binding polypeptides and complexes thereof having agonist activity. Also provided are methods for screening for complexes or polypeptides having agonist activity, enhancing the agonist activity of a polypeptide, and for agonizing a cell surface receptor using the complexes and polypeptide described herein.

公开(公告)号：US20210147562A1

公开(公告)日：2021-05-20

申请号：US17081784

申请日：2020-10-27

Applicant: Genentech, Inc.

Inventor： Gregory LAZAR ,  Jeong KIM ,  Jing ZHU ,  Yanli YANG ,  Randall BREZSKI

IPC: C07K16/28 ,  C07K16/32 ,  A61K47/68 ,  A61K38/02 ,  A61K39/395

Abstract: Provided herein are antigen binding polypeptides and complexes thereof having agonist activity. Also provided are methods for screening for complexes or polypeptides having agonist activity, enhancing the agonist activity of a polypeptide, and for agonizing a cell surface receptor using the complexes and polypeptide described herein.