公开(公告)号：US10369116B2

公开(公告)日：2019-08-06

申请号：US15554923

申请日：2016-02-22

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Yoko Fujiwara ,  Takashi Yasukochi ,  Yuka Takagi

IPC: A61K9/70 ,  A61K47/32 ,  A61K47/34 ,  A61K47/12 ,  A61K47/14 ,  A61M35/00

Abstract: A patch includes an adhesive layer and a release liner laminated on at least one surface of a backing. The adhesive layer comprises, as an adhesive base agent, at least one selected from the group consisting of acrylate-based adhesives and rubber-based adhesives, and the adhesive layer comprises 0.3 to 5% by mass of a nonfunctional silicone oil having a kinematic viscosity of 10 to 350 cSt at 25° C.

公开(公告)号：US09969688B2

公开(公告)日：2018-05-15

申请号：US15502793

申请日：2015-10-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Atsushi Sonobe ,  Takashi Yasukochi ,  Yasunori Takada ,  Kenji Atarashi ,  Motohiro Suzuki ,  Shinichi Yokota

IPC: C07D213/75

CPC classification number: C07D213/75 ,  A61K31/44

Abstract: The present invention provides a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein R is a hydrogen atom, a C1-6 alkyl group optionally substituted with one or more hydroxyl groups, a C1-6 alkoxy group, or a cyano group.

公开(公告)号：US11813364B2

公开(公告)日：2023-11-14

申请号：US17404571

申请日：2021-08-17

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Atsushi Sonobe ,  Takashi Yasukochi ,  Yasunori Takada

IPC: A61K9/70 ,  A61K31/407 ,  A61K47/14 ,  A61K47/10 ,  A61K47/12

CPC classification number: A61K9/7069 ,  A61K9/7053 ,  A61K31/407 ,  A61K47/10 ,  A61K47/14 ,  A61K9/7061 ,  A61K47/12

Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.

公开(公告)号：US10814002B2

公开(公告)日：2020-10-27

申请号：US16209084

申请日：2018-12-04

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Masayuki Suzuki ,  Hiroaki Okutsu ,  Takashi Yasukochi ,  Yasunori Takada

IPC: A61K47/12 ,  A61K9/70 ,  A61K47/06 ,  A61K47/14 ,  A61K31/55 ,  A61M37/00 ,  A61K31/407 ,  A61K47/10 ,  A61F13/00 ,  A61F13/02

Abstract: A method for producing a patch including a support layer, and an adhesive agent layer formed on the support layer and including sodium diacetate, a pressure-sensitive adhesive base agent, and asenapine and/or a pharmaceutically acceptable salt thereof. The sodium diacetate is generated from sodium acetate in the presence of the asenapine and/or salt thereof, a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is in range of 3.0 to 20 mg, and when a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is 6.4 mg and the patch is in contact with skin for 24 hours, Cmax of free asenapine is in range of 0.5 to 6.0 ng/mL and tmax of free asenapine is in range of 8 to 28 hr.

公开(公告)号：US20180289631A1

公开(公告)日：2018-10-11

申请号：US16008704

申请日：2018-06-14

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Atsushi Sonobe ,  Takashi Yasukochi ,  Yasunori Takada

IPC: A61K9/70 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K31/407

Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.

公开(公告)号：US20150164862A1

公开(公告)日：2015-06-18

申请号：US14417205

申请日：2013-07-25

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Masayuki Suzuki ,  Hiroaki Okutsu ,  Takashi Yasukochi ,  Yasunori Takada

IPC: A61K31/407 ,  A61K47/12 ,  A61K47/14 ,  A61K9/70

CPC classification number: A61K47/12 ,  A61K9/7038 ,  A61K9/7046 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/407 ,  A61K31/55 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61M37/00

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer comprises: a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 μm, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D50 of 10 μm or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; and an adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.

Abstract translation: 制备包含支持层和粘合剂层的贴剂的方法包括：混合制备步骤，其将粒径分布中累积体积为50％的粒径D50与甲酸钠的药学上可接受的盐混合， 40至1000μm，使得由乙酸钠生成的乙酸钠和二乙酸钠的粒径D50为10μm或更小，从而获得含有二乙酸钠和阿替平或其药学上可接受的盐的混合物; 以及通过使用通过将混合物与所述粘合剂层组合物混合而获得的粘合剂层组合物形成包含二乙酸钠，阿替平或其药学上可接受的盐的粘合剂层和粘合剂基剂的粘合剂层形成步骤 压敏胶基剂。