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公开(公告)号：US11850311B2
公开(公告)日：2023-12-26
申请号：US17281621
申请日：2019-09-25
Applicant: Hisamitsu Pharmaceutical Co., Inc.
Inventor： Masaki Yukuhiro , Yuka Takagi , Satoshi Amano
IPC: A61K9/70 , A61K31/407
CPC classification number: A61K9/7069 , A61K31/407
Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan δ) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.
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公开(公告)号：US09789188B2
公开(公告)日：2017-10-17
申请号：US14433939
申请日：2013-10-08
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Takuya Umemoto , Yuka Takagi , Yasunari Michinaka
IPC: A61K47/12 , A61K31/551 , A61K9/70
CPC classification number: A61K47/12 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K31/551
Abstract: A patch comprising a support layer and an adhesive agent layer, wherein the adhesive agent layer comprises at least one drug selected from the group consisting of emedastine and pharmaceutically acceptable salts thereof, at least one adhesive agent selected from the group consisting of rubber-based adhesive agents and silicone-based adhesive agents, and an alkali metal fumarate as a cohesive force-improving agent for the adhesive agent layer.
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公开(公告)号：US20210369637A1
公开(公告)日：2021-12-02
申请号：US17281621
申请日：2019-09-25
Applicant: Hisamitsu Pharmaceutical Co., Inc.
Inventor： Masaki Yukuhiro , Yuka Takagi , Satoshi Amano
IPC: A61K9/70 , A61K31/407
Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan δ) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.
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公开(公告)号：US20140170205A1
公开(公告)日：2014-06-19
申请号：US14123148
申请日：2012-05-23
Applicant: Hisamitsu Pharmaceutical Co., Inc.
Inventor： Naoyuki Uchida , Yuka Takagi , Toshiro Yamaguchi
IPC: A61K9/70 , A61K31/4045
CPC classification number: A61K9/7053 , A61K31/4045
Abstract: A ropinirole-containing patch comprises an adhesive agent layer and a support layer, the adhesive agent layer containing ropinirole and/or a pharmaceutically acceptable salt thereof, wherein a content of the ropinirole and/or the pharmaceutically acceptable salt thereof in terms of free ropinirole in the adhesive agent layer satisfies the following two conditions: 5 to 13.2% by mass relative to a total mass of the adhesive agent layer, and 0.12 to 2.7 mg/cm2 per unit area of the adhesive agent layer.
Abstract translation: 含罗匹尼罗的贴剂包含粘合剂层和支持层，所述粘合剂层含有罗匹尼罗和/或其药学上可接受的盐，其中根据游离罗哌卡罗的罗匹尼罗和/或其药学上可接受的盐的含量 粘合剂层满足以下两个条件：相对于粘合剂层的总质量为5〜13.2质量％，粘合剂层的每单位面积为0.12〜2.7mg / cm 2。
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Patent Agency Ranking
公开(公告)号：US11607394B2
公开(公告)日：2023-03-21
申请号：US16954627
申请日：2018-12-14
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Hiroyuki Araki , Yuka Takagi , Yoko Fujiwara , Hiroaki Kobayashi , Takao Kurokawa
IPC: A61P25/16 , A61K47/32 , A61K31/381 , A61K9/70
Abstract: The present invention provides a rotigotine-containing patch comprising: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer contains rotigotine and/or a pharmaceutically acceptable salt thereof,
the adhesive agent layer further contains a styrene-based thermoplastic elastomer, a petroleum-based resin and/or a terpene-based resin, an aliphatic alcohol, and a cross-linked polyvinylpyrrolidone, and
in the adhesive agent layer, a mass ratio of a content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form and a content of the cross-linked polyvinylpyrrolidone (content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form:content of the cross-linked polyvinylpyrrolidone) is 10:3 to 1:3.-
公开(公告)号：US20150250877A1
公开(公告)日：2015-09-10
申请号：US14433939
申请日：2013-10-08
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Takuya Umemoto , Yuka Takagi , Yasunari Michinaka
IPC: A61K47/12 , A61K31/551 , A61K9/70
CPC classification number: A61K47/12 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K31/551
Abstract: A patch comprising a support layer and an adhesive agent layer, wherein the adhesive agent layer comprises at least one drug selected from the group consisting of emedastine and pharmaceutically acceptable salts thereof, at least one adhesive agent selected from the group consisting of rubber-based adhesive agents and silicone-based adhesive agents, and an alkali metal fumarate as a cohesive force-improving agent for the adhesive agent layer.
Abstract translation: 一种贴剂，其包括支持层和粘合剂层，其中所述粘合剂层包含至少一种选自依达克汀及其药学上可接受的盐的药物，至少一种选自橡胶基粘合剂 助剂和硅氧烷粘合剂，以及作为粘合剂层的内聚力改善剂的富马酸碱金属盐。
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公开(公告)号：US11590106B2
公开(公告)日：2023-02-28
申请号：US17281623
申请日：2019-09-25
Applicant: Hisamitsu Pharmaceutical Co., Inc.
Inventor： Masaki Yukuhiro , Yuka Takagi , Yasunari Michinaka
IPC: A61K31/407 , A61K9/70 , A61K47/02 , A61K47/12 , A61K47/32
Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.
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公开(公告)号：US20210393587A1
公开(公告)日：2021-12-23
申请号：US17281623
申请日：2019-09-25
Applicant: Hisamitsu Pharmaceutical Co., Inc.
Inventor： Masaki Yukuhiro , Yuka Takagi , Yasunari Michinaka
IPC: A61K31/407 , A61K9/70 , A61K47/02 , A61K47/32 , A61K47/12
Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.
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公开(公告)号：US10369116B2
公开(公告)日：2019-08-06
申请号：US15554923
申请日：2016-02-22
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Yoko Fujiwara , Takashi Yasukochi , Yuka Takagi
Abstract: A patch includes an adhesive layer and a release liner laminated on at least one surface of a backing. The adhesive layer comprises, as an adhesive base agent, at least one selected from the group consisting of acrylate-based adhesives and rubber-based adhesives, and the adhesive layer comprises 0.3 to 5% by mass of a nonfunctional silicone oil having a kinematic viscosity of 10 to 350 cSt at 25° C.
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